Association of Neuromyelitis Optica With Severe and Intractable Pain

Qian, Peiqing; Lancia, Samantha; Alvarez, Enríque; Klawiter, Eric C.; Cross, Anne H.; Naismith, Robert T.

doi:10.1001/archneurol.2012.768

Cited by 87 publications

(112 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As documented in other neuromyelitis optica cohorts, a large percentage of our AQP4-Ab-positive TM patients suffer pain (86%); for a quarter of whom this pain is severe 1 3 13. This reinforces the importance of unravelling the aetiology of pain in NMOSD as a stepping-stone towards effective therapy development.…”

Section: Discussionsupporting

confidence: 77%

Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Tackley

Vecchio

Hamid

et al. 2016

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 77%

Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Tackley

Vecchio

Hamid

et al. 2016

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…Similar to a previous report (30), we found that affective and cognitive assessments were not correlated in MS patients (Table 2). Also similar to a previous report (15), our NMO patients showed more depressive symptoms than MS patients (Fig. 2).…”

Section: Discussionsupporting

confidence: 92%

“…In addition to the cognitive decline, affective dysfunction is another important feature used to evaluate mental function in MS and NMO patients. Indeed, recent reports show that MS patients score higher that healthy people on apathy tests (13,14) and NMO patients score higher than MS patients on depression scales (15). We, and other groups, have previously reported the efficacy of a computerized touch panel-type screening test for the early detection of Alzheimer's disease (AD), ischemic stroke (IS), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) (16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Cognitive and Affective Assessments of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) Patients Utilizing Computerized Touch Panel-type Screening Tests

et al. 2014

View full text Add to dashboard Cite

Objective Cognitive and affective dysfunctions are important aspects for patients with multiple sclerosis (MS) and neuromyelitis optica (NMO). Methods We herein examined the cognitive and affective ability in MS (n=35) and NMO (n=10) patients using computerized touch panel-type screening tests. Results While MS patients and normal controls (NC1, n=40) did not significantly differ in their scores from the Hasegawa dementia scale-revised (HDS-R) or the frontal assessment battery, MS patients did score significantly lower on the mini-mental state examination (MMSE). In contrast, NMO patients did not differ from the normal control group 2 (NC2, n=15) in any of the three cognitive assessments. We also examined the affective ability and found that MS patients scored significantly higher on the apathy scale (AS) compared with the NC1 group, while NMO patients scored significantly higher on the geriatric depression scale (GDS) compared with the NC2 group. Although the GDS and AS scores did not correlate with any of the cognitive assessments among MS patients, the AS scores did correlate with the MMSE and HDS-R among NMO patients. Compared with normal controls, the times to complete the flipping cards and arranging pictures games were significantly longer for MS patients but not for NMO patients. Conclusion These results indicate differences between some features of cognitive and affective dysfunctions between MS and NMO patients. Computerized touch panel-type screening tests may be a more useful and sensitive tool for the cognitive assessment of MS patients than NMO patients.

show abstract

“…12 As such, it is not surprising that the burden and prevalence of pain is even greater in patients with severe spinal cord damage from NMOSD, with 62-91% reporting its presence; research reveals that its pervasiveness impacts mood, mobility and quality of life. 4,5,13,14 Our patient experienced persistent central neuropathic pain for 3.5 years prior to…”

Section: Scrambler Therapy Is a Non-invasive Technology Approved By Tmentioning

confidence: 88%

Case Report: Scrambler Therapy for Treatment-Resistant Central Neuropathic Pain in a Patient with Transverse Myelitis

Mealy¹,

Newsome²,

Kozachik³

et al. 2019

International Journal of MS Care

View full text Add to dashboard Cite

Practice Points• Central neuropathic pain is a severely disabling component of immune-mediated diseases that affect the central nervous system.• Scrambler therapy is an emerging non-invasive pain modifying technique that has been used for peripheral neuropathic pain.• We describe use of Scrambler therapy for central neuropathic pain in a patient with transverse myelitis.3 Abstract Background: Central neuropathic pain is a severely disabling consequence of conditions that

show abstract

Association of Neuromyelitis Optica With Severe and Intractable Pain

Cited by 87 publications

References 31 publications

Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

Cognitive and Affective Assessments of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) Patients Utilizing Computerized Touch Panel-type Screening Tests

Case Report: Scrambler Therapy for Treatment-Resistant Central Neuropathic Pain in a Patient with Transverse Myelitis

Contact Info

Product

Resources

About