Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography

Abstract

To describe the measurement of anterior chamber area and anterior chamber volume by anteriorsegment optical coherence tomography and to investigate the association of these parameters with the presence of narrow angles. Methods: This was a cross-sectional study of subjects aged at least 50 years without ophthalmic symptoms recruited from a community clinic. All participants underwent standardized ocular examination and anterior-segment optical coherence tomography. Customized software was used to measure anterior chamber area (cross-sectional area bounded by the corneal endothelium, anterior surface of iris, and lens within the pupil) and anterior chamber volume (calculated by rotating the anterior chamber area 360°a round a vertical axis through the midpoint of the anterior chamber area). An eye was considered to have narrow angles if the posterior pigmented trabecular meshwork was not visible for at least 180°on gonioscopy with the eye in the primary position. Results: A total of 1922 subjects were included in the final analyses, 317 (16.5%) of whom had narrow angles. Mean anterior chamber area (15.6 vs 21.1 mm 2 ; PϽ.001) and anterior chamber volume (97.6 vs 142.1 mm 3 ; P Ͻ .001) were smaller in eyes with narrow angles compared with those in eyes without narrow angles. After adjusting for age, sex, anterior chamber depth, axial length, and pupil size, smaller anterior chamber area (odds ratio, 53.2; 95% confidence interval, 27.1-104.5) and anterior chamber volume (odds ratio, 40.2; 95% confidence interval, 21.5-75.2) were significantly associated with the presence of narrow angles. Conclusion: Smaller anterior chamber area and anterior chamber volume were independently associated with narrow angles in Singaporeans, even after controlling for other known ocular risk factors.

Angle closure glaucoma: a mechanistic review

“…Anterior chamber width (ACW) [25 ], anterior chamber area (ACA) and anterior chamber volume (ACV) [26 ] are recently identified AS-OCT parameters associated with angle closure. ACW was defined as the horizontal scleral spur-to-spur distance (Fig.…”

“…More recently, Wu et al [26 ] described the association of narrow angles with two other novel AS-OCT parameters: ACA and ACV. They evaluated 1922 individuals, of which 317 had narrow angles, and found that mean ACA (P < 0.001) and ACV (P < 0.001) were smaller in eyes with narrow angles compared with those without.…”

Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes

“…After the scleral spurs are identified, the software calculated the iris, cornea, and lens parameters automatically. Table 1 shows the AS-OCT parameters and their definitions 12,17,[21][22][23][24][25] used in this study. After obtaining the images, APAC and phacomorphic angle closures eyes underwent LPI and cataract extraction, respectively, as part of their standard medical care.…”

Penurunan Tekanan Intraokular Pascabedah Katarak pada Kelompok Sudut Bilik Mata Depan Tertutup dan Terbuka

“…10 Menurut Wu dkk, 11 kelompok subjek penelitian yang berusia di bawah 60 tahun memiliki sudut dan volume bilik mata depan yang lebih kecil. Menurut Wojciechowski dkk.…”