Association of MTHFR 677C > T and 1298A > C polymorphisms with susceptibility to attention deficit and hyperactivity disorder

Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

“…After the removal of overlapping articles and those that did not meet the inclusion criteria ( Fig 1 ), a total of five studies with ADHD including 434 cases and 670 controls [ 2 , 37 – 40 ], 18 studies with BD including 4167 cases and 5901 controls [ 28 – 31 , 41 – 53 ] and 44 studies with SCZ including 16,098 cases and 19913 controls were finally included in our meta-analysis [ 28 – 31 , 42 , 46 , 47 , 52 , 54 – 76 ]. The key characteristics of the studies and NOS scale information are presented in Table 1 .…”

“…Five previous retrospective studies investigated the association between MTHFR polymorphisms and ADHD [ 2 , 37 – 39 , 77 ]. Our results were very similar to those of Tahereh Sadeghiyeh [ 77 ], but not exactly the same as those of Saliha Baykal and Emel Ergul [ 37 , 38 ].…”

“…Five previous retrospective studies investigated the association between MTHFR polymorphisms and ADHD [ 2 , 37 – 39 , 77 ]. Our results were very similar to those of Tahereh Sadeghiyeh [ 77 ], but not exactly the same as those of Saliha Baykal and Emel Ergul [ 37 , 38 ]. A total of five retrospective studies were included, which represented MTHFR polymorphisms more accurately than previous published studies.…”

Associations of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

“…MTHFR is a key enzyme in folate metabolism, which converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that is required for the remethylation of homocysteine to methionine (Gohari et al, 2019;Karimi-Zarchi et al, 2019;Sadeghiyeh et al, 2020;Bahrami et al, 2021). The rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms are responsible for the synthesis of a thermolabile form of MTHFR enzyme with decreased enzymatic activity (Kiseljaković et al, 2008).…”

Investigation of the relationship between vitamin D and peripheral inflammatory parameters in children with attention deficit and hyperactivity disorder

“…Increase in homocysteine is one of the most important parameters indicating vitamin B12 and folate deficiency (9). It has also been reported that the polymorphism of the enzyme methyltetrafolate reductase, which is one of the OCM enzymes, plays a role in the etiology of ADHD (10).…”