Association of miRNA biosynthesis genes <i>DROSHA</i> and <i>DGCR8</i> polymorphisms with cancer susceptibility: a systematic review and meta-analysis

Wen, Jing; Lv, Zhi; Ding, Han-xi; Fang, Xinyuan; Sun, Mingjun

doi:10.1042/bsr20180072

Cited by 21 publications

(19 citation statements)

References 40 publications

(23 reference statements)

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“…It is indispensable for miRNAs biogenesis. Emerging evidence has supported that the genetic variations within DGCR8 were associated with various diseases [11–15]. The polymorphism in rs1640299 was reported to be associated with risk of laryngeal cancer [13] and bladder cancer [14], and could increase the effect of black carbon pollutant exposures on blood pressure (BP) [22].…”

Section: Discussionmentioning

confidence: 99%

“…DGCR8 also referred to as Pasha, could stabilize Drosha via protein- protein interaction, and take charge of recognizing ssRNA and dsRNA structures [10]. SNPs within the DGCR8 are associated with schizophrenia [11], primary open angle glaucoma [12] and various cancers [13–15]. However, the impact of polymorphisms in DGCR8 on the susceptibility to PE has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

Huang

Liu

et al. 2019

BMC Med Genet

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Background PE (preeclampsia) is a heterogeneous disorder with early onset PE (EOPE) and late onset PE (LOPE) subtypes. Associations between maternal miRNAs biosynthesis genes polymorphisms and risk of PE have been previously observed. However, the impact of polymorphisms in DGCR8 which is indispensable in miRNA maturing processing on the susceptibility to preeclampsia (PE) has not been elucidated yet. We, therefore, conducted a case-control study to evaluate the impact of polymorphisms in DGCR8 on the risk of EOPE and LOPE. Methods A total of 66 patients diagnosed with EOPE, 206 with LOPE and 330 healthy controls were recruited. Five SNPs in DGCR8 were genotyped including rs1558496, rs1640299, rs720012, rs720014, and rs9606241. Logistic regression was used to estimate the OR and the 95% CI for the associations. Results Increased risk of LOPE has been observed among patients with rs1640299 TG genotype (OR = 1.98 (95%CI: 1.38, 2.87), p = 2.32e-4) and rs720014 TC genotype (OR = 2.49 (95%CI: 1.72, 3.60), p = 1.40e-7). The DGCR8 rs1558496/ rs1640299/ rs720012/ rs720014/ rs9606241 haplotype T-G-A-C-A and T-G-A-C-G were associated with increased risk of LOPE (OR = 2.20 (95%CI: 1.49, 3.25), p = 5.90e-5, and 1.58 (95%CI: 1.06, 2.36), p = 0.024, respectively). And the haplotype T-T-G-T-A was associated with lower risk of LOPE (OR = 0.74 (95%CI: 0.58, 0.95), p = 0.018). These significant associations retained after false-positive discovery rate correction. However, none of the tested SNPs or haplotypes in DGCR8 gene is associated with risk of EOPE ( p > 0.05). Conclusions Polymorphisms in DGCR8 might participate in the pathological process of preeclampsia. The rs1640299 T > G and rs720014 T > C polymorphisms are associated with late onset preeclampsia susceptibility. Electronic supplementary material The online version of this article (10.1186/s12881-019-0887-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

Huang

Liu

et al. 2019

BMC Med Genet

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“…The authors of published papers were also contacted directly, if crucial data were not reported in original papers. When more than one of the same patient populations were included in different publications, only the most recent or complete study with the largest sample size was included in this meta-analysis [11].…”

Section: Methodsmentioning

confidence: 99%

Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis

Liu

Liu²,

Zhao

et al. 2019

Bioscience Reports

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Association between the xeroderma pigmentosum complementation group F (XPF)rs2276466 located in the excision repair cross complementation group 4 (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May 20, 2018, to obtain all the records evaluating the association between the rs2276466 polymorphism and the risk of all types of cancers. We used the odds ratio (OR) as a measure of effect, and pooled the data in a Mantel-Haenszel weighed random-effects meta-analysis to provide a summary estimate of the impact of this polymorphism on gastrointestinal cancer, neurogenic cancer and other cancers (breast cancer and SCCHN). All the analyses were carried out in STATA 14.1.11 case–control studies that consisted of 5730 cases and 6756 controls, were eventually included in our meta-analysis. The significant association was observed between the XPFrs2276466 polymorphism and neurogenic cancer susceptibility (recessive model: OR = 1.648, 95% CI = 1.294–2.098, P<0.001). Furthermore, no significant impact of this polymorphism was detected on decreased gastrointestinal cancer risk (dominant model: OR = 1.064, 95%CI = 0.961–1.177, P = 0.233). The rs2276466 polymorphism might play different roles in carcinogenesis of various cancer types. Current evidence did not suggest that this polymorphism was directly associated with gastrointestinal susceptibility. However, this polymorphism might contribute to increased neurogenic cancer risk. More preclinical and epidemiological studies are still imperative for further evaluation

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“…Recurrent homozygous deletions of Drosha were found in pineoblastoma (Snuderl et al, 2018). Single nucleotide polymorphisms (SNPs) in the sequence of Drosha gene were also found to correlate with high risk of cancer development (Wen et al, 2018). However, elevated levels of Drosha were found for a number of neoplasias: basal cell carcinoma, squamous cell carcinoma, and smooth muscle neoplasms (Sand et al, 2010).…”

Section: The Role Of Endogenous Mammalian Rnases In the Control Of Inmentioning

confidence: 99%

Surveillance of Tumour Development: The Relationship Between Tumour-Associated RNAs and Ribonucleases

Миронова

Vlassov

2019

Front. Pharmacol.

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Tumour progression is accompanied by rapid cell proliferation, loss of differentiation, the reprogramming of energy metabolism, loss of adhesion, escape of immune surveillance, induction of angiogenesis, and metastasis. Both coding and regulatory RNAs expressed by tumour cells and circulating in the blood are involved in all stages of tumour progression. Among the important tumour-associated RNAs are intracellular coding RNAs that determine the routes of metabolic pathways, cell cycle control, angiogenesis, adhesion, apoptosis and pathways responsible for transformation, and intracellular and extracellular non-coding RNAs involved in regulation of the expression of their proto-oncogenic and oncosuppressing mRNAs. Considering the diversity/variability of biological functions of RNAs, it becomes evident that extracellular RNAs represent important regulators of cell-to-cell communication and intracellular cascades that maintain cell proliferation and differentiation. In connection with the elucidation of such an important role for RNA, a surge in interest in RNA-degrading enzymes has increased. Natural ribonucleases (RNases) participate in various cellular processes including miRNA biogenesis, RNA decay and degradation that has determined their principal role in the sustention of RNA homeostasis in cells. Findings were obtained on the contribution of some endogenous ribonucleases in the maintenance of normal cell RNA homeostasis, which thus prevents cell transformation. These findings directed attention to exogenous ribonucleases as tools to compensate for the malfunction of endogenous ones. Recently a number of proteins with ribonuclease activity were discovered whose intracellular function remains unknown. Thus, the comprehensive investigation of physiological roles of RNases is still required. In this review we focused on the control mechanisms of cell transformation by endogenous ribonucleases, and the possibility of replacing malfunctioning enzymes with exogenous ones.

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Association of miRNA biosynthesis genes DROSHA and DGCR8 polymorphisms with cancer susceptibility: a systematic review and meta-analysis

Cited by 21 publications

References 40 publications

Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis

Surveillance of Tumour Development: The Relationship Between Tumour-Associated RNAs and Ribonucleases

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