Association of Milk and Meat Consumption with the Development of Breast Cancer in a Western Mexican Population

Galvan-Salazar, Hector R; Arreola-Cruz, Alejandro; Madrigal-Pérez, Daniela; Soriano-Hernández, Alejandro D.; Guzmán-Esquivel, José; Montes-Galindo, Daniel A.; López-Flores, Rodrigo A.; Espinoza-Gomez, Francisco; Rodríguez‐Sánchez, Iram P.; Newton-Sánchez, Óscar Alberto; Lara-Esqueda, Agustín; Martínez‐Fierro, Margarita L.; Briseño-Gomez, Xochitl G.; Delgado‐Enciso, Iván

doi:10.1159/000442230

Cited by 11 publications

(12 citation statements)

References 20 publications

(30 reference statements)

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“…Among women residing in rural areas, obesity and a high intake of milk were identified as risk factors for BC. A case-control study in Mexico (97 BC patients, 104 controls) reported that high milk consumption increased BC risk by 7.2 times, whereas the consumption of meat was not significantly associated with BC risk [340]. According to a case-control study (n = 333) in Uruguay, high intakes of whole milk was associated with significant increased risk of BC, whereas fermented milk products were associated with significant decreased risk [341].…”

Section: Breast Cancermentioning

confidence: 99%

Exosomes of pasteurized milk: potential pathogens of Western diseases

Melnik

Schmitz

2019

J Transl Med

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Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow's milk protects thermolabile vitamins and other organic compounds including bioactive and bioavailable exosomes and extracellular vesicles in the range of 40-120 nm, which are pivotal mediators of cell communication via systemic transfer of specific micro-ribonucleic acids, mRNAs and regulatory proteins such as transforming growth factor-β. There is compelling evidence that human and bovine milk exosomes play a crucial role for adequate metabolic and immunological programming of the newborn infant at the beginning of extrauterine life. Milk exosomes assist in executing an anabolic, growth-promoting and immunological program confined to the postnatal period in all mammals. However, epidemiological and translational evidence presented in this review indicates that continuous exposure of humans to exosomes of pasteurized milk may confer a substantial risk for the development of chronic diseases of civilization including obesity, type 2 diabetes mellitus, osteoporosis, common cancers (prostate, breast, liver, B-cells) as well as Parkinson's disease. Exosomes of pasteurized milk may represent new pathogens that should not reach the human food chain.

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Section: Breast Cancermentioning

confidence: 99%

Exosomes of pasteurized milk: potential pathogens of Western diseases

Melnik

Schmitz

2019

J Transl Med

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“…Further experiments concerning the effects of whole milk on the prostate carcinogenesis in rats revealed an increased tumor incidence [129]. Some studies indicate an inductive effect of milk consumption on the risk of developing breast cancer, although in turn the data situation is less clear in other studies [130][131][132]. In the case of individuals with lactose intolerance characterized by low consumption of milk and other dairy products, a decreased risk of developing lung, breast, and ovarian cancer was determined [133].…”

Section: Discussionmentioning

confidence: 99%

Potential Protective Protein Components of Cow’s Milk against Certain Tumor Entities

et al. 2021

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Milk and dairy products, especially from cow’s milk, play a major role in the daily human diet. It is therefore hardly surprising that the subject of milk is being extensively researched and that many effects of individual milk components have been characterized as a result. With the wealth of results available today, the influence of milk on the development of various types of cancer and, in particular, its often protective effects have been shown both in vitro and in vivo and in the evaluation of large-scale cohort and case-control studies. Various caseins, diverse whey proteins such as α-lactalbumin (α-LA), bovine α-lactalbumin made lethal to tumor cells (BAMLET), β-lactoglobulin (β-LG), or bovine serum albumin (BSA), and numerous milk fat components, such as conjugated linoleic acid (CLA), milk fat globule membrane (MFGM), or butyrate, as well as calcium and other protein components such as lactoferrin (Lf), lactoferricin (Lfcin), and casomorphines, show antitumor or cytotoxic effects on cells from different tumor entities. With regard to a balanced and health-promoting diet, milk consumption plays a major role in a global context. This work provides an overview of what is known about the antitumoral properties of proteins derived from cow’s milk and their modes of action.

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“…A Chinese study identified high milk consumption as a BC risk factor in women of rural regions [ 349 ]. Further controlled case studies show that milk consumption increases BC risk [ 350 , 351 ], whereas lactose intolerance reduces BC risk [ 352 ].…”

Section: Milk-induced Overactivation Of Mtorc1 and Diseases Of CIVmentioning

confidence: 99%

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

Melnik

2021

Biomolecules

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The consumption of cow’s milk is a part of the basic nutritional habits of Western industrialized countries. Recent epidemiological studies associate the intake of cow’s milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. This review presents current epidemiological and translational evidence linking milk consumption to the regulation of mTORC1, the master-switch for eukaryotic cell growth. Epidemiological studies confirm a correlation between cow’s milk consumption and birthweight, body mass index, onset of menarche, linear growth during childhood, acne vulgaris, type 2 diabetes mellitus, prostate cancer, breast cancer, hepatocellular carcinoma, diffuse large B-cell lymphoma, neurodegenerative diseases, and all-cause mortality. Thus, long-term persistent consumption of cow’s milk increases the risk of mTORC1-driven diseases of civilization. Milk is a highly conserved, lactation genome-controlled signaling system that functions as a maternal-neonatal relay for optimized species-specific activation of mTORC1, the nexus for regulation of eukaryotic cell growth, and control of autophagy. A deeper understanding of milk´s impact on mTORC1 signaling is of critical importance for the prevention of common diseases of civilization.

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Association of Milk and Meat Consumption with the Development of Breast Cancer in a Western Mexican Population

Cited by 11 publications

References 20 publications

Exosomes of pasteurized milk: potential pathogens of Western diseases

Exosomes of pasteurized milk: potential pathogens of Western diseases

Potential Protective Protein Components of Cow’s Milk against Certain Tumor Entities

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

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