Association of MIF−173G/C and MBL2 codon 54 gene polymorphisms with rheumatoid arthritis: A meta-analysis

Xie, Qiang; Wang, Shi‐Cun; Geng, Bin; Zhan, Fenglin; Xie, Jun; Li, Jun

doi:10.1016/j.humimm.2012.07.043

Cited by 17 publications

(12 citation statements)

References 45 publications

(58 reference statements)

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“…The secretion profiles of haplotypes observed in our study are in accordance with other published study on RA that has demonstrated the distribution of secretor haplotypes based on MBL levels in a larger Caucasian population of Dutch descent [57]. Recently a meta-analysis investigation has shown that MBL2*B (codon 54) variant is not associated with RA across all published study subjects irrespective of ethnicity, however when stratified by ethnicity in Asian populations, a significant contribution of MBL2*B (codon 54) variant was observed [58].…”

Section: Discussionsupporting

confidence: 91%

Mannose Binding Lectin and Susceptibility to Rheumatoid Arthritis in Brazilian Patients and Their Relatives

et al. 2014

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IntroductionRheumatoid arthritis (RA) is a commonly occurring systemic inflammatory auto immune disease and is believed to be associated with genetic factors. The innate immune complement protein Mannose binding lectin (MBL) and their MBL2 genetic variants are associated with different infectious and autoimmune diseases.MethodsIn a Brazilian cohort, we aim to associate the functional role of circulating MBL serum levels and MBL2 variants in clinically classified patients (n = 196) with rheumatoid arthritis including their relatives (n = 200) and ethnicity matched healthy controls (n = 200). MBL serum levels were measured by ELISA and functional MBL2 variants were genotyped by direct sequencing.ResultsThe exon1+54 MBL2*B variant was significantly associated with an increased risk and the reconstructed haplotype MBL2*LYPB was associated with RA susceptibility. Circulating serum MBL levels were observed significantly lower in RA patients compared to their relatives and controls. No significant contribution of MBL levels were observed with respect to functional class, age at disease onset, disease duration and/or other clinical parameters such as nodules, secondary Sjögren syndrome, anti-CCP and rheumatoid factor. Differential distribution of serum MBL levels with functional MBL2 variants was observed in respective RA patients and their relatives.ConclusionsOur results suggest MBL levels as a possible marker for RA susceptibility in a Brazilian population.

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Section: Discussionsupporting

confidence: 91%

Mannose Binding Lectin and Susceptibility to Rheumatoid Arthritis in Brazilian Patients and Their Relatives

et al. 2014

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“…However, further in‐depth studies are required to investigate the disparity in results in different population studies. Similar to a meta‐analysis study conducted on both the European and Asian population (Xie et al., ) of MIF (−159C/T 173G/C) gene polymorphisms, in our study, we also found predominant G/C genotype in RA patients but with higher 4.85‐fold increased risk (CI 2.94–8.02, p = .0001) for developing RA as compared to G/G genotype. We did not observe the homozygous variant for MIF gene polymorphism in both the groups.…”

Section: Discussionsupporting

confidence: 90%

Association of CD14 and macrophage migration inhibitory factor gene polymorphisms with inflammatory microRNAs expression levels in ankylosing spondylitis and polyarthralgia

Vishwakarma

Lakkireddy

Sravani

et al. 2018

Int J Immunogenetics

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This study aimed to investigate the genetic basis of ankylosing spondylitis (AS) and polyarthralgia (PA) conditions among Indian subjects through genotyping two immune regulatory genes CD14 (-159C>T) and MIF (-173G>C) and find their association with the expression levels of three circulating inflammatory miRNAs. This investigation may provide early genetic cause of these two forms of arthritis and more optimal biological targets to predict early therapeutic outcomes. A total of 140 patients (AS: 70 and PA: 70) and 156 controls were recruited from Indian population. CD14 and MIF genotyping was performed using ARMS-PCR. Expression level of three inflammatory miRNAs (miRNA-146a, miRNA-155 and miRNA-181) was quantified using RT-qPCR. C/T genotype of CD14 gene was found to cause 2.06-fold risk of developing AS (CI 1.06-5.98, p = .04) as compared to others and G/C genotype in MIF also shown significant variation between AS and control subjects. In PA subjects, CD14 genotypes (C/T) was found to be associated with disease susceptibility and G/C genotype of MIF gene polymorphism showed 4.71-fold risk of developing PA (CI 2.58-8.62, p = .0001). The study also revealed significant upregulation of miRNA-155 expression in AS subjects (p = .0001) with more than 1.3-fold difference between AS and PA as compared to the control subjects. miRNA-155 had strong association with AS patients with CD14 genotypes (p < .05) than PA and control subjects. This study provides better understanding of the mechanisms and disease susceptibility for MIF and CD14 genetic variants and inflammatory miRNAs networks involved in AS and PA.

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“…On the other hand, Donn et al (2002) presented association between -173C allele and JIA (juvenile idiopathic arthritis) in the UK population. Positive results were also shown in the Chinese population with RA (rheumatoid arthritis) (Liu et al, 2012;Xie et al, 2012).…”

Section: Discussionmentioning

confidence: 84%

Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome.

et al. 2014

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Nephrotic syndrome (NS) is the most common reason of proteinuria in children and can be caused by the pathology of renal glomeruli. Steroid therapy is typically used in this disorder. It has been shown that MIF is a cytokine which counteracts the immunosuppressive properties of glucocorticoids. The aim of this study was looking for a correlation between MIF polymorphisms and genetic susceptibility to steroid resistance in children with INS (Idiopathic NS). Methods: The study was performed in 71 patients with INS including SRNS (steroid resistance nephrotic syndrome) (41) and SSNS (steroid sensitive nephrotic syndrome) (30) and in 30 control subjects. We employed Sanger sequencing and capillary electrophoresis. Linkage disequilibrium was made using Haploview and PHASE. Results: We didn't observe a statistical significance between SNPs detected in patients with INS and controls. Our studies revealed statistical significance for two polymorphisms: rs2070767C>T and rs2000466T>G between patients with SRNS and SSNS. The results for rs34383331T>A are close to being statistically significant. Statistical significance was revealed for CATT5/CATT6 genotype in SRNS group vs SSNS group (OR=4.604, 95%CI=1.356-15.632, p=0.0168). We found that the frequency of 5/X-CATT genotype compared with X/X-CATT genotype was significantly higher in SRNS patients vs SSNS (OR=3.167, 95%CI=1.046-9.585, p=0.0426). In linkage disequilibrium analysis we didn't show involvement in susceptibility to INS and steroid sensitive phenotype. Conclusions: Our results suggest that the role of MIF polymorphisms in the susceptibility to positive response to steroid therapy is still unresolved. It indicates that MIF may be involved in indirect and complex molecular mechanisms of steroid activity in hormone-dependent metabolic pathways in children with INS. Because of ambiguous findings, pleiotropic features of this cytokine require that more research should be undertaken.

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Association of MIF−173G/C and MBL2 codon 54 gene polymorphisms with rheumatoid arthritis: A meta-analysis

Cited by 17 publications

References 45 publications

Mannose Binding Lectin and Susceptibility to Rheumatoid Arthritis in Brazilian Patients and Their Relatives

Mannose Binding Lectin and Susceptibility to Rheumatoid Arthritis in Brazilian Patients and Their Relatives

Association of CD14 and macrophage migration inhibitory factor gene polymorphisms with inflammatory microRNAs expression levels in ankylosing spondylitis and polyarthralgia

Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome.

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