Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with myocardial infarction in Tunisian young patients

Slama, Dhouha Berredjeb Ben; Mrissa, Najiba Fekih; Haggui, Abdeddayem; Nsiri, Brahim; Haouala, Habib; Gritli, Nasreddine

doi:10.1007/s00580-013-1836-z

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Myocardial infarction is one of the most prevalent cardiovascular diseases worldwide 15 and it is a major contributor to cardiovascular mortality. 16 It is a complex, multifactorial, and polygenic disease that involves interaction between the genetic predisposition and environmental influences. 17 Traditional risk factors, including diet, diabetes, dyslipidemia, hypertension, obesity, inflammation, alcohol consumption, and smoking, predict around 50% of the absolute risk for a cardiovascular event, and the remaining risk can be attributed to genetic factors, including the presence of the C677T MTHFR polymorphism, as evidenced from our findings.…”

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Garakanidze

Costa

Bronze-Rocha

et al. 2018

Clin Appl Thromb Hemost

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Methylenetetrahydrofolate reductase ( MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comparison with healthy individuals and its association with arterial thrombosis. We enrolled 214 participants: 101 with arterial thrombosis (71.3% males; mean age: 66.3 ± 12.1 years) and 113 controls (67.3% males; mean age: 56.6 ± 11.3 years). Genomic DNA was extracted from dry blood spot on Whatman filter paper. Polymerase chain reaction was performed to determine MTHFR C677T polymorphism. Frequency of C677T allele polymorphism in controls was 21.2%, which corresponded to heterozygous and homozygous stage frequencies of 35.4% and 3.5%, respectively. In patient group, an allelic frequency of 33.2% was found, which corresponded to the presence of 48.5% of heterozygous and 8.9% of homozygous individuals. Comparing the frequency of mutated alleles between the 2 groups, a significantly high frequency of mutated alleles was found in patient group ( P < .05). In conclusion, high frequency of MTHFR C677T polymorphism found in arterial thrombosis patient group suggests that this polymorphism might increase the risk of arterial thrombosis in Georgian patients.

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Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Garakanidze

Costa

Bronze-Rocha

et al. 2018

Clin Appl Thromb Hemost

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“…The plasma concentrations of homocysteine can be increased due to a variety of hereditary or dietary conditions [ 19 ]. The methylenetetrahydrofolate reductase (MTHFR) gene has drawn considerable attention as it has been linked to an increased plasma level of homocysteine, which has been associated with an increased risk of MI [ 20 ]. Homocysteine, an amino acid that contains sulfur, has significance in CAD and is an absolute atherosclerotic risk of coronary and peripheral vascular lesions [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor

et al. 2023

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Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor.

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C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis

Alizadeh

Djafarian

Moradi

et al. 2016

International Journal of Cardiology

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Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with myocardial infarction in Tunisian young patients

Cited by 4 publications

References 25 publications

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor

C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis

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