C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis

Mirabbasi

Clinical Laboratory Analysis

et al. 2018

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Opposite impact of Methylene tetrahydrofolate reductase C677T and Methylene tetrahydrofolate reductase A1298C gene polymorphisms on systemic inflammation

Mirabbasi

Clinical Laboratory Analysis

et al. 2018

“…MTHFR C677T and A1298C polymorphisms have been studied extensively in the context of many human diseases and conditions, such as: lung cancer, [ 22 ] cervical cancer, [ 23 ] rheumatoid arthritis, [ 24 ] myocardial infarction, [ 25 ] migraine, [ 26 ] and recurrent pregnancy loss. [ 27 ] There are also studies on the association between the occurrence of MTHFR polymorphisms and ALL development in adults and children in different regions and subpopulations.…”

Section: Discussionmentioning

confidence: 99%

The methylenetetrahydrofolate reductase 677T-1298C haplotype is a risk factor for acute lymphoblastic leukemia in children

et al. 2017

The etiology of acute lymphoblastic leukemia (ALL) is complex, linked with both environmental exposures and genetic factors. Functional variants of the methylenetetrahydrofolate reductase (MTHFR) gene result in disturbance in folate metabolism and may affect susceptibility to cancer. The study was performed to evaluate whether MTHFR C677T and A1298C polymorphisms, analyzed separately and together, are associated with the development of ALL in a population under 18 years of age of Caucasian ancestry.The study included 117 pediatric patients (59% males, mean age at diagnosis 7.4 ± 5.2 years) with ALL, confirmed by conventional immunophenotyping surface-marker analysis and 404 healthy control subjects (48.5% men, mean age 37.7 ± 11.3 years). The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014). The 677T-1298C haplotype was found in ALL patients but not in controls (frequency 0.598%; P <.0001). The observed frequency of carriers of this rare haplotype was 12%, including 677CT/1298CC (1.7%), 677TT/1298AC (6.0%), and 677CT/1298AC (4.3%) genotypes.The MTHFR 677T allele alone or in combination with the MTHFR 1298C allele significantly increases the risk of development of ALL in Polish population under 18 years of age. Further studies of haplotype composition in subjects with the 677CT/1298AC genotype are necessary to assess the risk of childhood ALL.

“…There was sort of a geographic increase in the Europe (north to south) and China (north to south decrease). In the big meta-analysis of Alizadeh S and coworkers (32) in the population of patients with MI there were differences in the polymorphism of MTHFR according to the ethnical groups. Their results showed that the T allele of C677T polymorphism is not associated with an increased risk for MI in European, Asian and North American population, but is associated in African population.…”

Section: Discussionmentioning

confidence: 99%

Association of Factor II G20210A, Factor V G1691A and methylenetetrahydrofolate reductase C677T gene polymorphism with different forms of myocardial infarction: ST segment elevation and non-ST segment elevation

et al. 2020

Kratak naslov rada: Povezanost polimorfizama gena za faktore koagulacije II, V i metilentetrahydrofolat reduktazu sa različitim formama infarkta miokarda Doprinos koautora izradi studije i objavljivanju rada: Milica Ćućuz Jokićdoprinela ideji, planu, prikupljanju podataka i analizi i tumačenju podataka i izrađivanju rukopisa. Vesna Ilić-doprinela ideji, planu, prikupljanju podataka i analizi i tumačenju podataka i izrađivanju rukopisa. Bojana Cikota-Aleksić-doprinela ideji, planu, prikupljanju podataka i analizi i tumačenju podataka i izrađivanju rukopisa. Slobodan Obradović-doprino ideji, planu, prikupljanju podataka i analizi i tumačenju podataka i ispravljao kritički značajni intelektualni sadrţaj rukopisa. Zvonko Magić-doprino ideji, planu, prikupljanju podataka i analizi i tumačenju podataka i ispravljao kritički značajni intelektualni sadrţaj rukopisa.