Association of Metabolic Syndrome With Sudden Sensorineural Hearing Loss

Jung, Su Young; Shim, Haeng Seon; Hah, Young Min; Kim, Sang Hoon

doi:10.1001/jamaoto.2017.3144

Cited by 54 publications

(56 citation statements)

References 30 publications

(86 reference statements)

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“…Our findings are reinforced by the results of a prospective longitudinal registry study in 245,000 Swedish conscripts, supporting the hypothesis that SNHL might be a clinical feature of MetS. 32 We found four of the five components of MetS to be independent associated factors of having SNHL in TS patients, so that each component by itself may present together with SNHL in TS. Microangiopathy is one of the proposed mechanisms for the development of SNHL, as the cochlear organ is particularly vulnerable to transient ischemia due to its highly energetic necessities and lack of collateral arterial blood flow.…”

Section: Dovepresssupporting

confidence: 84%

“…In concordance with these findings, both a European multi-center study and a Danish study reported that high BMI and highfrequency SNHL may be associated. 32,34 Similarly, among the components of MetS, hypertriglyceridemia had the second-highest aOR for SNHL in our study. Levels of TAG, TC and LDL-c, as well as atherogenic indexes (TC/HDL-c ratio, TAG/HDL-c ratio, AIP, LDL-c/ HDL-c ratio and Non-HDL-c/HDL-c ratio) were significantly increased in TS subjects with SNHL compared to non-SNHL TS individuals.…”

Section: Dovepresssupporting

confidence: 67%

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<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Álvarez-Nava¹,

Racines-Orbe²,

Witt³

et al. 2020

TACG

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Background and purpose: Metabolic syndrome (MetS) is a disorder associated with an increased risk of cardiovascular disease. The frequency of each component of MetS in Turner syndrome (TS) subjects is high. An elevated incidence of hearing loss has also been reported in TS. Sensorineural hearing loss (SNHL) affects at least half of young women with TS. The association between MetS and SNHL has not been previously considered in TS. The aim of this study is to evaluate the association between these two conditions. Patients and Methods: Cross-sectional anthropometric, cardio-metabolic and audiological data were obtained from a cohort consisting of unrelated TS subjects (>20 years of age; n = 93). Metabolic syndrome was defined according to the International Diabetes Federation criteria. Types and severity of hearing loss were based on the American Speech Hearing Association guidelines. Results: Hearing loss was detected in 74% of ears from adult TS subjects and SNHL was observed in half of our TS subjects. The prevalence of MetS in TS subjects with or without SNHL was 64% and 11%, respectively (P < 0.05). After adjusting for age, MetS was related to a ninefold increase in the odds of SNHL. This odds increased in a stepwise manner as the number of MetS components increased. Conclusion: MetS and its individual components were associated factors for SNHL in TS subjects. A reduction in the number and severity of the components of MetS might potentially contribute to decreasing the progression of SNHL at younger ages, but further studies will be needed to explain the underlying pathological mechanism connecting MetS and SNHL.

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Section: Dovepresssupporting

confidence: 84%

Section: Dovepresssupporting

confidence: 67%

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Álvarez-Nava¹,

Racines-Orbe²,

Witt³

et al. 2020

TACG

View full text Add to dashboard Cite

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“…It is however worth mentioning that one earlier report found a positive correlation between higher levels of systolic blood pressure and age-related hearing loss in the speech frequencies 25 . Another study demonstrated the hearing loss level to be higher in patients with than without metabolic syndrome, but the difference was not statistically significant 26 . Similar results were observed in terms of audiogram patterns.…”

Section: Discussionmentioning

confidence: 93%

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Xie

Dai

Liu

et al. 2020

Sci Rep

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. the incidence of iSSnHL in the Western countries' population was estimated to 5-20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. previous studies have reported that comorbidities, including hypertension, diabetes mellitus (DM), and hyperfibrinogenemia are risk factors of ISSNHL. This study aimed at investigating the clinical characteristics, laboratory parameters and comorbidities of patients with iSSnHL. our study suggests that the annual incidence of iSSnHL in China mainland is 19 per 100 000. The clinical characteristics and prevalence of comorbidities of ISSNHL patients are different according to age distribution and hearing results. Moreover, the patients with vertigo, hypertension, DM and high TG suffered more often from severe hearing loss compared with the counterparts. this indicates that the cardiovascular and metabolic diseases (hypertension and hyperlipidemia) appeared to be closely associated with the occurrence and severity of iSSnHL.

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“…The annual prevalence of ISSNHL is 10 per 100,000 persons in the Republic of Korea, and 5-20 per 100,000 persons in the USA [Jung et al, 2018]. It is characterized by hypoxia in the inner ear, and although the pathophysiology of ISSNHL remains unknown, multiple underlying conditions such as viral infections, labyrinthine membrane breaks, vascular occlusion, and autoimmune-associated factors are presumed causes [Jackler and De La Cruz, 1989;Murphy-Lavoie, et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial

et al. 2018

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Objectives: This study aimed to investigate the efficacy of simultaneous steroid and hyperbaric oxygen therapy (HBOT) in patients with severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL), which has a poor prognosis. Methods: Sixty patients diagnosed with severe to profound ISSNHL (≥70 dB HL) were randomly divided into two groups in a prospective controlled trial: an oral steroid + intratympanic steroid injection (ITSI) group (control group) and an oral steroid + ITSI + HBOT group (study group). Pure-tone audiometry (PTA) results and word discrimination scores (WDS) were compared between the two groups before treatment and 10 days and 1, 2, and 3 months after treatment. Hearing improvement was assessed using the modified American Academy of Otolaryngology-Head and Neck Surgery criteria. Analyses were by both intention to treat and per protocol. Results: A total of 58 patients completed the 3-month follow-up, and 2 patients in the study group were excluded due to follow-up loss in the per-protocol analysis. In the intention-to-treat and per-protocol analyses, the study group showed significantly better hearing levels than did the control group at 500 Hz (p < 0.05) 1 month after treatment and at 1 kHz (p < 0.05) 3 months after treatment. However, the average PTA values and PTA at 2, 4, and 8 kHz showed no significant difference. WDS improvement was significantly higher in the study group compared to the control group 3 months after treatment by both per-protocol (66.4 ± 13.3 and 56.7 ± 19.1%, respectively; p = 0.029) and intention-to-treat analyses (65.9 ± 14.1 and 56.7 ± 19.1%, respectively; p = 0.035). The sum of complete and partial hearing recovery for the study group was significantly higher than that for the control group by per-protocol analysis (60.7 vs. 33.3%; p = 0.037) and intention-to-treat analysis (60.0 vs. 33.3%; p = 0.038). Conclusion: These results demonstrate that the addition of HBOT to steroid combination therapy does not improve the average PTA values in severe to profound ISSNHL; however, it was associated with a better outcome at 500 Hz 1 month after treatment and, at 1 kHz, WDS 3 months after treatment. The sum of complete and partial hearing recovery was significantly higher for the study group than for the control group.

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Association of Metabolic Syndrome With Sudden Sensorineural Hearing Loss

Abstract: The rate of recovery from SSNHL was lower among patients with metabolic syndrome than among those without metabolic syndrome, and prognosis was poorer in patients with 4 or more diagnostic factors of the metabolic syndrome.

Cited by 54 publications

References 30 publications

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial

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