Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Abstract

Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. the incidence of iSSnHL in the Western countries' population was estimated to 5-20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. previous studies have reported that comorbidities, including hypertension, diabetes mellitus (DM), and hyperfibrinogenemia are risk factors of ISSNHL. This study aimed at investigating the clinical characteristics, laboratory parameters and comorbidities of patients with iSSnHL. our study suggests that the annual incidence of iSSnHL in China mainland is 19 per 100 000. The clinical characteristics and prevalence of comorbidities of ISSNHL patients are different according to age distribution and hearing results. Moreover, the patients with vertigo, hypertension, DM and high TG suffered more often from severe hearing loss compared with the counterparts. this indicates that the cardiovascular and metabolic diseases (hypertension and hyperlipidemia) appeared to be closely associated with the occurrence and severity of iSSnHL.

Association of sudden sensorineural hearing loss with dementia: a nationwide cohort study

“…Although many patients with SSHL recover spontaneously (32–65%), the condition’s underlying causes and pathogenesis remain unclear [ 10 ]. Moreover, the onset of SSHL is generally in the fifth or sixth decade of life, which is earlier than that of patients with ARHL [ 12 ].…”

“…It is an urgent neurotology disorder requiring immediate identification and treatment [ 11 ]. SSHL occurs at any age but usually affects people in their 40s and 50s [ 12 ], with an annual incidence of 5–20 per 100,000 people per year in developed countries and with an equal sex distribution [ 13 ]. It can occur in isolation or as part of a systemic disorder.…”

Efficacy of Various Corticosteroid Treatment Modalities for the Initial Treatment of Idiopathic Sudden Hearing Loss: A Prospective Randomized Controlled Trial

“…The overall incidence of diagnosed ISSNHL ranges from 5 to 20/100,000 persons per year. The true incidence of ISSNHL is, without doubt, higher than reported, because the spontaneous recovery rate ranges from 32 to 65% [Xie et al, 2020]. Recovery most often occurs within 2 weeks after the onset of symp-with various factors, such as a delay from onset to treatment, the type of hearing loss, and the presence of vertigo [Slattery et al, 2005].…”

Hipoacusia neurosensorial súbita, el gran dilema de la otorrinolaringología. Una revisión de la literatura

“…La disfunción mitocondrial promueve la liberación de proteínas pro apoptóticas, con actividad de la Caspasa 3 y Caspasa 1, que incluso ocasionan daño neuronal debido a la liberación excesiva de glutamato o la disminución de los factores de crecimiento. 64,102,11 Vascular y hematológico…”

“…y PLR podrían reflejar el estado inflamatorio, siendo estos marcadores mientras más altos de mejor pronóstico. La hiperfibrinogenemia ha sido postulada como factor de riesgo importante, por su consecuente riesgo de trombosis que podría desencadenar HNSS 13,100,9,102. b. ImagenEn el primer acercamiento con el paciente no se recomienda utilizar TAC, a excepción que tenga signos de alarma como antecedente de trauma, focalidad neurológica o enfermedad crónica del oído.…”