Association of metabolic syndrome with severity of coronary artery disease

Mahalle, Namita; Garg, MK; Naik, Sadanand; Kulkarni, Mukund G.

doi:10.4103/2230-8210.139238

Cited by 19 publications

(7 citation statements)

References 31 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, individuals from the case group had lower total cholesterol, LDL, HDL, and triglycerides compared with those from the control group. Our result is in support of previous reports that individuals with MetS have persistently higher risk levels of common anthropometric and clinical disease markers, which could lead to health-threatening disease conditions like CHD [ 5 , 6 ].…”

Section: Discussionsupporting

confidence: 92%

“…The highest frequency (76.7%) was of dyslipidemia in the disease group individuals followed by GO (56.2%), hypertension (53.4%), and CO (44.5%). The high frequency of cardiometabolic risks in Pakistani subjects also supports the previous finding that the clustering of cardiometabolic dysregulations could lead to MetS and further complications, especially CHD [ 4 , 5 , 6 ]. Genetic relationships between metabolic dysregulations and the development/severity of cardiovascular diseases have also been reported [ 7 , 8 ], especially the rs1333049 SNP of the 9p21 locus [ 29 , 30 , 42 ].…”

Section: Discussionsupporting

confidence: 83%

“…The major risk factors leading to increasing rates of disease are sedentary and stressful lifestyles coupled with excessive consumption of caloric-rich foods and obesity [ 5 , 11 , 40 , 41 ]. MetS and its components have been associated with CAD [ 4 , 5 , 6 ]. All case subjects of the present study had MetS regardless of CHD; the anthropometric and clinical variables in these groups were in risk ranges and higher compared to the individuals from the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Depending upon worldwide population variabilities like sex, age, race/ethnicity, and lifestyle-related factors, MetS prevalence ranges from 10 to 84% [ 2 ], while in the South Asian population it ranges from 11.9 to 49%, with the highest rate of 54.9% in Pakistan [ 3 , 4 ]. Cardiometabolic dysregulations and MetS lead to a number of health-threatening issues including coronary heart disease (CHD) [ 5 , 6 , 7 , 8 ]. MetS is predicted to increase the risk of CHD episodes by two-fold and mortality by one-and-a-half-fold in the next 5 to 10 years [ 9 , 10 , 11 ], regardless of gender and age [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

9p21 Locus Polymorphism Is A Strong Predictor of Metabolic Syndrome and Cardiometabolic Risk Phenotypes Regardless of Coronary Heart Disease

Zafar

Saqlain²,

Raja

et al. 2022

Genes

View full text Add to dashboard Cite

The world population is genetically predisposed to metabolic syndrome (MetS) and its components, also known as cardiometabolic risk phenotypes, which can cause severe health complications including coronary heart disease (CHD). Genetic variants in the 9p21 locus have been associated with CHD in a number of populations including Pakistan. However, the role of the 9p21 locus in MetS and cardiometabolic risk phenotypes (such as obesity, hypertension, hyperglycemia, and dyslipidemia) in populations with CHD or no established CHD has not been explored. Therefore, the present study was designed to explore the association of the minor/risk allele (C) of 9p21 locus SNP rs1333049 with MetS or its risk phenotypes regardless of an established CHD, in Pakistani subjects. Genotyping of rs1333049 (G/C) was performed on subjects under a case-control study design; healthy controls and cases, MetS with CHD (MetS-CHD+) and MetS with no CHD (MetS-CHD−), respectively. Genotype and allele frequencies were calculated in all study groups. Anthropometric and clinical variables (Means ± SD) were compared among study groups (i.e., controls, MetS + CHD and MetS-CHD) and minor/risk C allele carriers (GC + CC) vs. non-carriers (Normal GG genotype). Associations of the risk allele of rs1333049 SNP with disease and individual metabolic risk components were explored using adjusted multivariate logistic regression models (OR at 95% CI) with a threshold p-value of ≤0.05. Our results have shown that the minor allele frequency (MAF) was significantly high in the MAF cases (combined = 0.63, MetS-CHD+ = 0.57 and MetS-CHD− = 0.57) compared with controls (MAF = 0.39). The rs1333049 SNP significantly increased the risk of MetS, irrespective of CHD (MetS-CHD+ OR = 2.36, p < 0.05 and MetS-CHD− OR = 4.04, p < 0.05), and cardiometabolic risk phenotypes; general obesity, central obesity, hypertension, and dyslipidemia (OR = 1.56–3.25, p < 0.05) except hyperglycemia, which lacked any significant association (OR = 0.19, p = 0.29) in the present study group. The 9p21 genetic locus/rs1333049 SNP is strongly associated with, and can be a genetic predictor of, MetS and cardiometabolic risks, irrespective of cardiovascular diseases in the Pakistani population.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

9p21 Locus Polymorphism Is A Strong Predictor of Metabolic Syndrome and Cardiometabolic Risk Phenotypes Regardless of Coronary Heart Disease

Zafar

Saqlain²,

Raja

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

“…Many epidemiological and clinical studies have confirmed the link between MetS and an increased risk of coronary artery disease (CAD), which is the leading cause of death worldwide. Morbidity and mortality from CAD are higher in MetS patients [4]. India accounts for 17% of global CAD mortality.…”

Section: Introductionmentioning

confidence: 97%

To Study the Risk Factors Associated With Metabolic Syndrome in Coronary Artery Disease Patients

Kaur

KAUR²,

Mittal³

et al. 2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Indians are more likely to develop metabolic syndrome (MetS). The additive predictive value of MetS components for cardiovascular disease is still under debate. The current study aimed to study the risk factors associated with MetS in coronary artery disease (CAD) patients. Methods: This retrospective study was conducted in the Department of Biochemistry in collaboration with the Department of Medicine, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Up on 100 patients already diagnosed with CAD, attending medicine OPD and IPD. Anthropometric measurements, and estimation of fasting blood glucose, high-density lipoprotein-cholesterol, and triglycerides were done. MetS prevalence was estimated as per the guidelines of NCEP ATP III. Results: In our study, we observed a high incidence of MetS in patients with CAD. MetS was diagnosed, gender-wise distribution resulted in 62% in females and 48% in males. Risk factors for MetS in CAD patients were highly significant with increasing age, sedentary lifestyle, and diabetes. Waist circumference, fasting blood glucose levels, and triacylglycerol were found to have a significant *p<0.001 value with MetS in CAD patients. Conclusions: The current study found a strong link between MetS and its risk factors in CAD patients. Thus, the assessment of MetS and its components might help identify people at a higher risk of advancing CAD in the future. Hence, effective MetS management may significantly reduce morbidity and mortality due to CAD.

show abstract

Macrovascular complications: Coronary artery disease

Faheem,

Zafar

2024

BIDE' S Diabetes Desk Book

View full text Add to dashboard Cite

Association of metabolic syndrome with severity of coronary artery disease

Cited by 19 publications

References 31 publications

9p21 Locus Polymorphism Is A Strong Predictor of Metabolic Syndrome and Cardiometabolic Risk Phenotypes Regardless of Coronary Heart Disease

9p21 Locus Polymorphism Is A Strong Predictor of Metabolic Syndrome and Cardiometabolic Risk Phenotypes Regardless of Coronary Heart Disease

To Study the Risk Factors Associated With Metabolic Syndrome in Coronary Artery Disease Patients

Macrovascular complications: Coronary artery disease

Contact Info

Product

Resources

About