Association of metabolic syndrome and hepatitis B infection in a Chinese population

Luo, Benyan; Wang, Yanwen; Wang, Kang

doi:10.1016/j.cca.2007.01.012

Cited by 41 publications

(49 citation statements)

References 11 publications

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“…The current study is also in keeping with data from Taiwan and China indicating that HBV-infected patients have reduced triglyceride level and a lower prevalence of metabolic syndrome overall [26,27]. The observation is consistent across these large population studies and unlikely to be due to chance.…”

Section: Discussionsupporting

confidence: 91%

“…In transgenic mouse and cell line models, hepatitis B X (HBx) protein expression results in hepatic steatosis and activation of the nuclear factor kappaB pathway [24,25]. On the other hand, two studies on ethnic Chinese population failed to demonstrate a positive correlation between hepatitis B infection and metabolic syndrome [26,27]. The association with fatty liver has also not been adequately tested in large human studies.…”

Section: Introductionmentioning

confidence: 95%

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Hepatitis B virus infection and fatty liver in the general population

Wong

Chu

et al. 2012

Journal of Hepatology

202

204

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 95%

Hepatitis B virus infection and fatty liver in the general population

Wong

Chu

et al. 2012

Journal of Hepatology

202

204

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“…The results from Table 2 is consistent with the reported works of Ianello et al (2003) and Luo et al (2007) who showed an inverse correlation between HBV-infection and elevated serum triglyceride levels even though their studies were carried out in different geographical locations and settings. Upon infection, the viral X protein (HBxP) interacts with host hepatic metabolic genes such as sterol regulator element binding protein-1 (SREBP-1), carbohydrate regulator element binding protein (ChREBP), peroxisome proliferator activator receptor-gamma (PPAR-γ), among others.…”

Section: Discussionsupporting

confidence: 83%

Lowered Serum Triglyceride Levels among Chronic Hepatitis B-Infected Patients in Ghana

Kwarteng¹,

Owusu²,

Afihene³

et al. 2013

Jnl Sci Tech

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Dyslipidemia is a common finding in most studies of liver diseases. Little is however known about the effect of the two pathological stages of chronic hepatitis B (CHB) infection -chronicsymptomatic and asymptomatic -on the distribution of serum lipids in CHB infection. We conducted a study on CHB-infected patients attending specialist care at the Gastro-Intestinal (GI) Clinic at the Komfo Anokye Teaching Hospital (KATH) during a 7-month period. 64 participants were randomly sampled over the period. On the basis of serological and liver enzyme assays, participants were categorised as chronic asymptomatic, chronic symptomatic and healthy individuals. The relationship between the hosts pathological stage of infection were evaluated with the indices of lipid metabolism -LDL, HDL, triglyceride, and total serum cholesterol using ANOVA. The 64 volunteers recruited in the study were found to consist of 18 patients (28.1%) who were chronic symptomatic, 35 patients (54.7%) who were chronic asymptomatic hepatitis B, and 11 (17.2%) were healthy subjects. Significant overall male dominance was observed among all categories of population enrolled (p=0.0063). Serum triglyceride levels decreased more among the CHB-infected population compared to the healthy individuals (p=0.0010) with value lowest among the chronic symptomatic population. Basal serum cholesterol, HDL, and LDL were unaffected by the disease. This work reveals that serum triglyceride is significantly lowered in CHB infection and that the extent of this decrease in host is independent of the pathological stage of the infection.

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“…According to one early study from Shanghai, the prevalence of NAFLD in participants who were seropositive for hepatitis B surface antigen (HBsAg) was even less than HBsAg-negative counterparts (8% vs. 15%) [26,64]. This could partly be due to an inverse relationship between the presence of MetS and serum HBsAg-positive status in Chinese people [65,66]. Therefore, persons with chronic HBV infection are not a highrisk population for NAFLD.…”

Section: Nafld and Chronic Viral Hepatitis In Chinamentioning

confidence: 94%

Epidemiology of non-alcoholic fatty liver disease in China

Fan

Farrell

2009

Journal of Hepatology

463

371

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Fatty liver (steatosis) is highly prevalent in China and is more often linked to obesity than to alcoholism. Among more affluent regions of China, the community prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 15%. With the increasing pandemic of obesity, the prevalence of NAFLD has approximately doubled in the past decade. The risk factors resemble those in other ethnic populations, but it is important to note that ethnic-specific definitions of central obesity, obesity and metabolic syndrome are more useful in assessment of Chinese people. The full range of histological manifestations of NAFLD has been demonstrated in Chinese patients, but to date hepatic severity is generally mild. In contrast to chronic hepatitis C, steatosis is less common in patients with chronic hepatitis B; it is associated with metabolic, and not viral factors and does not appear to affect disease severity. Although long-term outcomes of NAFLD in Chinese populations remain unclear, it may be a predictor of metabolic disorders, diabetes and cardiovascular disease. Public health interventions are therefore indicated to halt or reverse the national trend of obesity in China so as to improve liver as well as metabolic health.

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Association of metabolic syndrome and hepatitis B infection in a Chinese population

Cited by 41 publications

References 11 publications

Hepatitis B virus infection and fatty liver in the general population

Hepatitis B virus infection and fatty liver in the general population

Lowered Serum Triglyceride Levels among Chronic Hepatitis B-Infected Patients in Ghana

Epidemiology of non-alcoholic fatty liver disease in China

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