Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons

Abstract

The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45–64 years). Material and methods. In this study, we have used data of 533 persons (247 men and 286 women) aged 45– 64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001–2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (≥5 mmol/L) and decreased level of lipid-standardized vitamin E (<20 mmol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods. Results. Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age. Conclusion. Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45–64-year-old persons.

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

“…However, there is a lack of information on the interaction between MetS and aging over the OxS status among elderly women. Previous studies in this area were predominantly conducted on individuals with multi-metabolic disorders (such as diabetes, hypertension, or hyperlipidemia) (8,14,16,20). By contrast, our study population sample had no metabolic or specific established diseases.…”

Changes in the prevalence of metabolic syndrome and smoking habits during a 10-year period and relation between these risk factors and ischemic heart disease among men aged 45–64 years

“…Įvertinus MS ir rūkymo įpročių derinio įtaką išeminių pokyčių EKG dažniui, nustatyta, kad, palyginus su niekada nerūkiusiais asmenimis be MS, tarp rūkančiųjų, kuriems nustatytas MS, ir tarp metusiųjų rūkyti, kuriems nustatytas MS, šios IŠL formos dažnis buvo didesnis, tačiau reikšmingai nesiskyrė. Per pastarąjį dešimtmetį daugelyje šalių atliekama vis daugiau tyrimų, skirtų MS, kuris yra IŠL ir kitų lėtinių neinfekcinių ligų rizikos veiksnių kompleksas (7,8,12,(22)(23)(24). MS ir rūkymas yra vieni pagrindinių IŠL rizikos veiksnių, kurie nepriklausomai vienas nuo kito didina šios ligos riziką (9,12,13,25,26 (19,4 proc.…”

“…Pastaraisiais metais daugelyje populiacijų skiriamas didelis dėmesys metaboliniam sindromui (MS), nes jis yra individualių rizikos veiksnių (nutukimo, hiperglikemijos, aterogeninės dislipidemijos ir arterinės hipertenzijos) kompleksas, kuris turi įtakos ne tik išeminei širdies ligai (IŠL), bet ir kitoms lėtinėms neinfekcinėms ligoms pasireikšti (1,2). Medicinos mokslo literatūroje pateikiama vis daugiau duomenų, kad MS yra metabolizmo sutrikimas, žymiai didinantis širdies ir kraujagyslių ligų pasireiškimą ir ankstyvos mirties riziką (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Kauno miesto 35-64 metų gyventojų MONICA-2 studijos imties (904 vyrų ir 882 moterų) 13 metų stebėjimo (nuo 1987 iki 2000 m.) duomenų analizė parodė, kad MS didina mirtingumo nuo IŠL riziką (8).…”

Population-based study in Lithuania: lifestyle factors and risk of metabolic syndrome

“…Most of these studies investigated an association between lifestyle habits and MS defined by Adult Treatment Panel III definition [15][16][17][18]20]. Data of previous investigation of Kaunas middle-aged population show that MS defined by Adult Treatment Panel III definition was associated with ischemic heart disease only in men aged 45-64 years [4,5]. Our recent investigation compared the prevalence of MS using three different definitions, and their ability to identify the risk of ischemic heart disease.…”

“…Recent analyses estimated that people who have MS are at increased risk of developing of cardiovascular disease [1][2][3][4][5][6]. The World Health Organization (WHO) [7], Adult Treatment Panel III (NCEP ATP III) [8] and International Diabetes Federation (IDF) [9] define the syndrome differently, but all include the same components with slightly different criteria.…”