Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Antonopoulos, Stavros; Mylonopoulou, M.; Angelidi, Angeliki M.; Kousoulis, Antonis A.; Tentolouris, Nicholas

doi:10.1016/j.diabres.2017.06.015

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Epidemiologically, Lp(a) levels have a significant positive relation with serum levels of matrix GLA protein (MGP), a known inhibitor of bone morphogenetic protein-2 (BMP-2) ( 52 ). If this association were due to Lp(a) induction of MGP, then one would expect Lp(a) to have an inhibitory effect on BMP-2 and an inverse association with vascular calcification.…”

Section: Lipoprotein(a) [Lp(a)]mentioning

confidence: 99%

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

Tintut

Hsu

Demer

2018

Front. Cardiovasc. Med.

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Previously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins. These compounds serve many of the same functions in vascular and valvular calcification as they do in skeletal bone calcification. Hyperlipidemia leads to accumulation of lipoproteins in the subendothelial space of cardiovascular tissues, which leads to formation of mildly oxidized phospholipids, which are known bioactive factors in vascular cell calcification. One lipoprotein of particular interest is Lp(a), which showed genome-wide significance for the presence of aortic valve calcification and stenosis. It carries an important enzyme, autotaxin, which produces lysophosphatidic acid (LPA), and thus has a key role in inflammation among other functions. Matrix vesicles, extruded from the plasma membrane of cells, are the sites of initiation of mineral formation. Phosphatidylserine, a phospholipid in the membranes of matrix vesicles, is believed to complex with calcium and phosphate ions, creating a nidus for hydroxyapatite crystal formation in cardiovascular as well as in skeletal bone mineralization. This review focuses on the contributions of lipids, phospholipids, lipoproteins, and autotaxin in cardiovascular calcification, and discusses possible therapeutic targets.

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Section: Lipoprotein(a) [Lp(a)]mentioning

confidence: 99%

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

Tintut

Hsu

Demer

2018

Front. Cardiovasc. Med.

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“…The factors influencing the occurrence and development of CACS include age, body mass index (BMI), diabetes, hypertension, smoking, inflammatory factors, fibrinogen, and dyslipidemia, etc [7][8][9][10][11] . Intervention studies on CAC mainly focus on controlling lipid abnormalities 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Predictive Model for Severe Coronary Artery Calcification in ESKD Patients

Tang,

Qian,

Zeng

et al. 2023

Preprint

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IntroductionThe Agatston coronary artery calcification score (CACS) is an assessment index for coronary artery calcification (CAC). This study aims to explore the characteristics of CAC in end-stage kidney disease (ESKD) patients and establish a predictive model to assess the risk of severe CAC in patients.MethodsCACS of ESKD patients was assessed using an electrocardiogram-gated coronary computed tomography (CT) scan with the Agatston scoring method. A predictive nomogram model was established based on stepwise regression. An independent validation cohort comprised of patients with ESKD from multicentres.Results369 ESKD patients were enrolled in the training set, and 127 patients were included in the validation set. In the training set, the patients were divided into three subgroups: no calcification (CACS = 0, n = 98), mild calcification (0 < CACS ≤ 400, n = 141) and severe calcification (CACS > 400, n = 130). Among the four coronary branches, the left anterior descending branch (LAD) accounted for the highest proportion of calcification. Stepwise regression analysis showed that age, dialysis vintage, β-receptor blocker, calcium-phosphorus product (Ca × P), and alkaline phosphatase (ALP) level were independent risk factors for severe CAC. A nomogram that predicts the risk of severe CAC in ESKD patients has been internally and externally validated, demonstrating high sensitivity and specificity.ConclusionCAC is both prevalent and severe in ESKD patients. In the four branches of the coronary arteries, LAD calcification is the most common. Our validated nomogram model, based on clinical risk factors, can help predict the risk of severe coronary calcification in ESKD patients who cannot undergo coronary CT analysis.

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Vitamin K

Bourron

Phan

2019

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Cited by 5 publications

References 49 publications

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

Predictive Model for Severe Coronary Artery Calcification in ESKD Patients

Vitamin K

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