Vitamin K

Bourron, Olivier; Phan, Franck

doi:10.1097/mco.0000000000000541

Cited by 8 publications

(1 citation statement)

References 32 publications

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“…Osteocalcin (OC) is one of the most crucial vitamin K-dependent proteins that are involved in glucose metabolism and homeostasis [ 28 ]. It has been previously hypothesised that there is a continuous signalling cycle between pancreatic β-cells and the skeletal system where insulin binding to its receptor on osteoblasts induces osteocalcin release that in consequence regulates pancreatic insulin production and improves insulin resistance [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin K4 supplementation on insulin resistance in individuals with type 2 diabetes: a double-blind randomised placebo-controlled clinical trial

et al. 2023

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Purpose The purpose of this study was to assess the possible clinical effects of vitamin K4 supplementation in individuals with type 2 diabetes namely insulin resistance, glycaemic control, and lipid profile. Methods This was a prospective randomised double-blind placebo-controlled clinical trial. A total of 106 patients were randomised to receive either 1 mg of vitamin K4 (menadiol diacetate) or placebo for 24 weeks. Results Ninety patients (n = 45 in each study group) were included in the final analysis. After 24 weeks, homeostatic model assessment of insulin resistance (HOMA-IR) (16.54 ± 7.81 vs. 29.09 ± 36.56, P = 0.027) and fasting serum insulin (FSI) (6.86 ± 3.45 vs. 11.13 ± 12.66 µU/ml, P = 0.032) were significantly lower in the vitamin K group compared to placebo. Additionally, triglycerides (TG) (144.94 ± 50.7 vs. 172.8 ± 101.5 mg/dl, P = 0.031) and very low-density lipoproteins (VLDL) levels (28.9 ± 9.88 vs. 34.6 ± 20.30 mg/dl, P = 0.027) decreased significantly in the vitamin K group after 24 weeks compared to baseline. Moreover, more patients in the vitamin K group (35.6%) had their antidiabetic medication doses reduced after 24 weeks compared to placebo (13.3%, P = 0.029). Conclusion Vitamin K4 supplementation for 24 weeks is capable of improving insulin resistance and TG levels in individuals with type 2 diabetes. In addition, the improvement in insulin resistance was reflected in the decrease in antidiabetic medication doses. However, it did not affect fasting plasma glucose (FPG) or glycated haemoglobin (HbA1c). Trial registration The study was registered on clinicaltrials.gov with ID: NCT04285450.

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Section: Discussionmentioning

confidence: 99%