Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis

Loo, Wings T.Y.; Wang, Min; Li, Jin; Cheung, Mary; Li, G.R.

doi:10.1016/j.archoralbio.2011.03.011

Cited by 51 publications

(49 citation statements)

References 58 publications

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“…, Loo et al. ), and one study had four groups [one without CP and chronic kidney disease (CKD), one with CP and without CKD, one without CP and with CKD and one with CP and CKD] (Luczyszyn et al. ), and for this meta‐analysis only groups without CKD were included.…”

Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase‐1 promoter ‐1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta‐analysis and systematic review

Xiao

2013

J Clinic Periodontology

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Matrix metalloproteinase-1 promoter -1607 1G/2G (rs1799750) polymorphism may have no effect on the disease susceptibility of CP in Caucasian, Asian and Brazilian mixed populations. Besides, this polymorphism may not play a direct role in severity of CP among both Caucasian and Asian populations, and between this polymorphism and smoking there may be no interactions to be associated with CP risk in Caucasian population.

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Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase‐1 promoter ‐1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta‐analysis and systematic review

Xiao

2013

J Clinic Periodontology

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“…In particular, IL-6 is able to stimulate the synthesis of all the acute phase proteins involved in the inflammatory response C-reactive protein, serum amyloid A, fibrinogen, α1-chymotrypsin and haptoglobin [9]. Cyclooxygenase-2 (COX-2) is an enzyme involved in the conversion of arachidonic acid to prostaglandins, with a consequent important role in inflammatory responses, also in the periodontium [10], [11]. COX-2 expression is induced by cytokines [12] and, on the other hand, prostaglandins are important regulators of IL-6 production by gingival fibroblasts [13].…”

Section: Introductionmentioning

confidence: 99%

Association between COX-2 rs 6681231 Genotype and Interleukin-6 in Periodontal Connective Tissue. A Pilot Study

et al. 2014

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ObjectivesThe aim of this pilot study was to investigate associations between IL-6 and COX-2 expression in gingival biopsies and both clinical diagnosis and genotypes in the IL-6 and COX-2 genes.DesignA case-control study included 41 gingival biopsies obtained from Caucasian patients grouped according to clinical diagnosis of gingival health (n = 10), gingivitis (n = 15) or chronic periodontitis (n = 16). Immunohistochemistry analyses were performed to determine COX-2 expression in lamina propria, IL-6 expression in lamina propria and gingival epithelium and level of inflammatory cell infiltrate. Individual DNA was extracted and genotyped by real-time PCR for IL6 SNPs rs 2069827 and rs 2069825 and for COX-2 rs 6681231.ResultsThe percentage of cellular COX-2 expression was associated with the extent of periodontal disease (Arbes index p = 0.026) and inflammatory infiltrate (p<0.0001). No association was observed between IL6 haplotypes and cells positive to IL-6 or COX-2 in gingival tissues. The COX-2 rs 6681231 was associated with cells positive to IL-6 in the connective tissue (p = 0.032).ConclusionsCOX-2 expression in gingival tissues may be a marker of periodontal disease severity. COX-2 rs 6681231 may be associated with IL-6 local production in gingival tissues.

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“…Total MMP-9 levels and its active form have been demonstrated to significantly increase with periodontal inflammation in comparison to controls, composed of gingivitis and healthy subjects, and to drop along with inflammation after periodontal therapy (Makela et al 1994;Bildt et al 2008) (Figure 1 been able to conclude specific associations with the susceptibility to develop periodontitis or disease severity. Similar allele and genotype frequencies have been demonstrated at the MMP-9 -1562 and -R+279Q polymorphic sites between periodontitis patients and healthy controls, despite the presence of significantly increased protein levels in serum and saliva of diseased subjects (Isaza-Guzman et al ; Loo et al 2011;de Souza et al 2005;Chen et al 2007;Gurkan et al 2008). Nevertheless, the -1572T allele might be associated with a severe form of chronic periodontitis in men (Holla et al 2006).…”

Section: Matrix Metalloproteinases (Mmps): Destructive Versus Regulatmentioning

confidence: 67%

The Role of Immuno-Inflammatory Response in the Pathogenesis of Chronic Periodontitis and Development of Chair-Side Point of Care Diagnostics

Hernández

Vernal²,

Sorsa³

et al. 2012

Pathogenesis and Treatment of Periodontitis

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Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis

Cited by 51 publications

References 58 publications

Matrix metalloproteinase‐1 promoter ‐1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta‐analysis and systematic review

Matrix metalloproteinase‐1 promoter ‐1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta‐analysis and systematic review

Association between COX-2 rs 6681231 Genotype and Interleukin-6 in Periodontal Connective Tissue. A Pilot Study

The Role of Immuno-Inflammatory Response in the Pathogenesis of Chronic Periodontitis and Development of Chair-Side Point of Care Diagnostics

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