Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration

Abstract

Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the MMP1 1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the MMP1 2G/2G genotype and degeneration; in contrast, there was no association between either the MMP3 or the MMP9 genotype and degeneration. Our results may indicate a role for the MMP1 polymorphism in TMJ degeneration.

Overexpression of Shox2 Leads to Congenital Dysplasia of the Temporomandibular Joint in Mice

“…As shown in Figure 5A,B, while strong MMPs activity is found in the glenoid fossa, and an above background level of MMPs activity is also seen in the condyle. Consistent with this enhanced total MMPs activity, we found that MMP9 and MMP13, which have been shown to be elevated in the TMJ osteoarthritis and are capable of degrading collagens and Aggrecan [17,18], exhibit enhanced expression in the Wnt1-Cre ; pMes-stop Shox2 TMJ at P0 and/or P7 stage (Figure 5E–L). These results indicate that enhanced MMPs activities are responsible for the reduction of ECM components, which may ultimately lead to the dysplasia of condyle and glenoid fossa in Wnt1-Cre ; pMes-stop Shox2 mice.…”

“…The changes of the ECM composition are associated with pathological processes of cartilage degeneration in TMJ osteoarthritis, accompanied by the up-regulation of MMPs [17,25,26]. Cartilage degeneration is a characteristic feature that results from the loss of collagens and PGS.…”

Pathophysiology and Pharmacologic Control of Osseous Mandibular Condylar Resorption

“…For example, MMP, vitamin D receptor, aromatase, and estrogen receptor polymorphisms appear to be associated with higher incidences of articular bone loss, including the TMJ. [96][97][98][99] Planello et al 99 reported that MMP-1 polymorphisms were more commonly seen in a large degenerative TMJ population as compared with healthy control subjects.…”

ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents

“…Literatures have also reported that occurrence of some TMDs was related to genetic polymorphisms of ANKH inorganic pyrophosphate transport regulator (ANKH) [21], catechol-O-methyltransferase (COMT) [22] and matrix metallopeptidase 1 (MMP1) [23]. This implied a potential genetic influence on TMJ clicking, which has not been fully understood.…”