Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case–control study

Nasri, Kaouther; Fradj, Mohamed Kacem Ben; Touati, Asma; Aloui, Mariem; Jemaa, Nadia Ben; Masmoudi, Aïda; Elmay, Michèle Véronique; Omar, Souhail; Feki, Moncef; Kaabechi, Naziha; Marrakchi, Raja; Gaigi, Soumeya Siala

doi:10.1002/bdra.23418

Cited by 31 publications

(31 citation statements)

References 49 publications

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“…In concordance with our results, Nasri et al ., in a case–control study conducted in Tunisia, found that low vitamin B12 concentration is related to an increased risk of NTD. In an Iranian study, no relation between the serum vitamin B12 and NTD was found…”

Section: Discussionsupporting

confidence: 93%

Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Senousy

Farag

Gouda

et al. 2018

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 93%

Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Senousy

Farag

Gouda

et al. 2018

J of Obstet and Gynaecol

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“…According to a study in 1170 women in northwest China, the prevalence of vitamin B-12 deficiency was 45% [49], indicating that vitamin B-12 supplementation maybe also be needed to prevent NTDs in China. The negative association between vitamin B-12 and the risk of NTDs is also observed in other populations [50,51,52], and remains significant even in folic acid–fortified populations [53,54]. Transcobalamin II ( TCN2 ) is a carrier protein that can bind vitamin B12.…”

Section: B-vitamins One-carbon Metabolism and Ntdsmentioning

confidence: 96%

Nutrition, One-Carbon Metabolism and Neural Tube Defects: A Review

Wahlqvist

2016

Nutrients

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Neural tube defects (NTDs) are a group of severe congenital malformations, induced by the combined effects of genes and the environment. The most valuable finding so far has been the protective effect of folic acid supplementation against NTDs. However, many women do not take folic acid supplements until they are pregnant, which is too late to prevent NTDs effectively. Long-term intake of folic acid–fortified food is a good choice to solve this problem, and mandatory folic acid fortification should be further promoted, especially in Europe, Asia and Africa. Vitamin B2, vitamin B-6, vitamin B-12, choline, betaine and n-3 polyunsaturated fatty acids (PUFAs) can also reduce the NTD risk by interacting with the one-carbon metabolism pathway. This suggest that multivitamin B combined with choline, betaine and n-3 PUFAs supplementation may have a better protective effect against NTDs than folic acid alone. Genetic polymorphisms involved in one-carbon metabolism are associated with NTD risk, and gene screening for women of childbearing age prior to pregnancy may help prevent NTDs induced by the risk allele. In addition, the consumption of alcohol, tea and coffee, and low intakes of fruit and vegetable are also associated with the increased risk of NTDs, and should be avoided by women of childbearing age.

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“…The recognition and treatment of vitamin B12 deficiency is critical since it is a reversible cause of bone marrow failure and demyelinating nervous system disease in the general population [3]. For pregnant women, maternal serum vitamin B12 concentration has been reported to gradually decline throughout normal pregnancy with the lowest concentration reached in late gestation, and maternal vitamin B12 deficiency has been associated with an increased risk of adverse pregnancy outcomes (e.g., neural tube defects, preterm delivery, and intrauterine growth retardation) indicating the importance of sufficient vitamin B12 intake/status during pregnancy for optimal fetal development and growth [4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women

Choi

Lim

et al. 2016

Nutrients

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This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes.

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Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case–control study

Cited by 31 publications

References 49 publications

Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Nutrition, One-Carbon Metabolism and Neural Tube Defects: A Review

A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women

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