2015
DOI: 10.1002/bdra.23418
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Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case–control study

Abstract: Lower concentrations of folate and vitamin B12 are related to the increased risk of NTDs. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTDs. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTDs incidence in Tunisia.

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Cited by 35 publications
(40 citation statements)
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“…In concordance with our results, Nasri et al ., in a case–control study conducted in Tunisia, found that low vitamin B12 concentration is related to an increased risk of NTD. In an Iranian study, no relation between the serum vitamin B12 and NTD was found…”
Section: Discussionsupporting
confidence: 93%
“…In concordance with our results, Nasri et al ., in a case–control study conducted in Tunisia, found that low vitamin B12 concentration is related to an increased risk of NTD. In an Iranian study, no relation between the serum vitamin B12 and NTD was found…”
Section: Discussionsupporting
confidence: 93%
“…According to a study in 1170 women in northwest China, the prevalence of vitamin B-12 deficiency was 45% [49], indicating that vitamin B-12 supplementation maybe also be needed to prevent NTDs in China. The negative association between vitamin B-12 and the risk of NTDs is also observed in other populations [50,51,52], and remains significant even in folic acid–fortified populations [53,54]. Transcobalamin II ( TCN2 ) is a carrier protein that can bind vitamin B12.…”
Section: B-vitamins One-carbon Metabolism and Ntdsmentioning
confidence: 96%
“…The recognition and treatment of vitamin B12 deficiency is critical since it is a reversible cause of bone marrow failure and demyelinating nervous system disease in the general population [3]. For pregnant women, maternal serum vitamin B12 concentration has been reported to gradually decline throughout normal pregnancy with the lowest concentration reached in late gestation, and maternal vitamin B12 deficiency has been associated with an increased risk of adverse pregnancy outcomes (e.g., neural tube defects, preterm delivery, and intrauterine growth retardation) indicating the importance of sufficient vitamin B12 intake/status during pregnancy for optimal fetal development and growth [4,5,6,7]. …”
Section: Introductionmentioning
confidence: 99%