Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Senousy, Sameh M.; Farag, Mona K.; Gouda, Ahmed; Noury, M.A. El; Dabbous, Ola A.; Gaber, Khaled R.

doi:10.1111/jog.13751

Cited by 18 publications

(7 citation statements)

References 36 publications

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“…If precocious puberty is found in children younger than 10 years of age, it is advised to delay pubertal onset and development (eg, with luteinizing hormone‐releasing hormone [LH‐RH] analog) . Females who are sexually active and/or trying to conceive a child, taking folic acid supplementation along with maintaining adequate levels of vitamin B12 may reduce the risk for having a fetus with a neural tube defect …”

Section: Methodsmentioning

confidence: 99%

“…95 Females who are sexually active and/or trying to conceive a child, taking folic acid supplementation along with maintaining adequate levels of vitamin B12 may reduce the risk for having a fetus with a neural tube defect. [96][97][98] Women seem to be more sexually active than men in some studies from the USA and the Netherlands. 93,99 In an Italian study, men were more active.…”

Section: Sexuality and Fertilitymentioning

confidence: 99%

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EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

Stein

Bogaert

Doğan

et al. 2019

Neurourology and Urodynamics

100

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Background: In childhood, the most common reason for a neurogenic bladder is related to spinal dysraphism, mostly myelodysplasia.Aims: Herein, we present the EAU/ESPU guidelines in respect to the diagnostics, timetable for investigations and conservative management including clean intermittent catheterization (CIC). Material and Methods: After a systematic literature review covering the period 2000 to 2017, the ESPU/EUAU guideline for neurogenic bladder underwent an update. Results: The EAU/ESPU guideline panel advocates a proactive approach. In newborns with spina bifida, CIC should be started as soon as possible after birth. In those with intrauterine closure of the defect, urodynamic studies are recommended be performed before the patient leaves the hospital. In those with closure after birth urodynamics should be done within the next 3 months. Anticholinergic medication (oxybutynin is the only well-investigated drug in this age group-dosage 0.2-0.4 mg/kg weight per day) should be applied, if the urodynamic study confirmed detrusor overactivity. Close follow-up including ultrasound, bladder diary, urinalysis, and urodynamics are necessary within the first 6 years and after that the time intervals can be prolonged, depending on the individual risk and clinical course. In all other children with the suspicion of a neurogenic bladder due to various reasons as tethered cord, inflammation, tumors, trauma, or other reasons as well as those with anorectal malformations, urodynamics-preferable video-urodynamics, should be carried out as soon as there is a suspicion of a neurogenic bladder and conservative treatment should be started soon after confirmation of the diagnosis of neurogenic bladder. With conservative treatment the upper urinary tract is preserved in up to 90%, urinary tract infections are common, but not severe, complications of CIC are quite rare and continence can be achieved at adolescence in up to 80% without further treatment. ORCID Raimund Stein

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Section: Methodsmentioning

confidence: 99%

Section: Sexuality and Fertilitymentioning

confidence: 99%

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

Stein

Bogaert

Doğan

et al. 2019

Neurourology and Urodynamics

100

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“…As regards neural tube defects, low vitamin B12 and B9 status are risk factors for neural tube defects (NTDs) as they lead to an increase of Hcy levels [59][60][61]. The monitoring of Hcy levels might be important in understanding and following cases with NTDs.…”

Section: Pregnancymentioning

confidence: 99%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

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Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case–control experimental designs and the study of interactions between different factors it should be emphasized.

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“…En un estudio multicéntrico de casos (n = 318) y controles (n = 702) en la India se reportó que las madres de fetos con DTN presentaron concentraciones de holotranscobalamina significativamente más bajas que los controles (25.4 vs. 31.7 pM, respectivamente; p < 0.001), así como concentraciones de Hcy marginalmente más altas (10.5 vs. 10.2 mM, respectivamente; p = 0.026) 36 . Otro estudio en Egipto (50 casos, 70 controles) también reportó mayor concentración de Hcy, MMA y menor concentración de vitB12 sérica en los casos de DTN que en el grupo de controles 37 .…”

Section: Estado Materno De Folato Vitamina B12 Homocisteína Y Resultados Perinatalesunclassified

Importancia de la vitamina B12 y el folato en la salud perinatal

Rodríguez-Cano¹,

Perichart-Perera²,

Gutiérrez‐Castrellón³

2023

GMM

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El desarrollo fetal se caracteriza por una gran plasticidad y capacidad para responder a factores ambientales, donde la metilación del ADN es indispensable para el desarrollo embrionario adecuado. El metabolismo de un carbono proporciona grupos metilo para la metilación y el desarrollo del ADN fetal, y depende en gran medida del estado nutricio materno. El embarazo es una etapa donde el suministro de donantes de metilo es crítico y la demanda de nutrimentos que apoyen este proceso, como lo son el folato y la vitamina B12, está aumentada. La insuficiencia o desequilibrio de estos dos micronutrimentos puede alterar los patrones epigenéticos, la síntesis y reparación del ADN, y afectar procesos del crecimiento y desarrollo fetal, teniendo consecuencias negativas en la salud de la descendencia a largo plazo. El estado del folato y la vitamina B12 se han asociado con la metilación global del ADN, así como con genes específicos relacionados con funciones neurológicas, con el desarrollo embrionario, el metabolismo energético, el crecimiento, y con la leptina. Además, estados alterados de ambas vitaminas se han asociado con mayor riesgo de resultados perinatales como defectos del tubo neural, prematurez, bajo peso al nacer, preeclampsia, así como obesidad y resistencia a la insulina materna e infantil, y disminución del desarrollo neurocognitivo infantil. La suplementación, aunada a una dieta adecuada, podría ser una estrategia necesaria para prevenir dichos resultados y mejorar la salud maternofetal.

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Association between biomarkers of vitamin B12 status and the risk of neural tube defects

Cited by 18 publications

References 36 publications

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Importancia de la vitamina B12 y el folato en la salud perinatal

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