Association of marital status with cardiovascular outcome in patients with breast cancer

Guan, Tianwang; Wang, Yuyan; Li, Feng; Chen, Dongting; Wei, Qingqian; Wang, Kenie; Zhang, Hanbin; Yang, Jinming; Zeng, Jin; Lai, Yanxian; Yang, Zhengxia; Liu, Cheng

doi:10.21037/jtd-21-1261

Cited by 4 publications

(7 citation statements)

References 45 publications

(55 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Marital status is one of the important psychosocial factors but has been ignored in PCNSL ( 20 , 27 ). In the present study, unmarried PCNSL and PCNS-DLBCL patients had reduced NCSS than married patients, suggesting that marriage plays a beneficial role through social and emotional support ( 20 , 27 , 28 ). Married patients have greater psychological and financial support from their spouses, enabling patients to better relieve mental distress and share finances ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…Married patients have greater psychological and financial support from their spouses, enabling patients to better relieve mental distress and share finances ( 29 ). Additionally, patient adherence to treatment plans and lifestyle habits may depend on the supervision of a partner or spouse during treatment, thus, improving their prognosis ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

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Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

Chi

Zhou²,

Luo³

et al. 2023

Front. Oncol.

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ObjectiveThe study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL).MethodsThis multi-center cohort study included 2497 patients with PCNSL in the Surveillance, Epidemiology and End Results (SEER) database from 2007 to 2016, with a mean follow-up of 4.54 years. The non-cancer-specific death risk in patients with PCNSL and primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) was evaluated using the proportion of deaths, standardized mortality ratio (SMR), and absolute excess risk (AER). Univariate and multivariate competing risk regression models were utilized to identify the risk factors of NCSS.ResultsPCNSL was the most frequent cause of death in PCNSL patients (75.03%). Non-cancer-specific causes constituted a non-negligible portion of death (20.61%). Compared with the general population, PCNSL patients had higher risks of death from cardiovascular disease (CVD) (SMR, 2.55; AER, 77.29), Alzheimer’s disease (SMR, 2.71; AER, 8.79), respiratory disease (SMR, 2.12; AER, 15.63), and other non-cancer-specific diseases (SMR, 4.12; AER, 83.12). Male sex, Black race, earlier year of diagnosis (2007–2011), being unmarried, and a lack of chemotherapy were risk factors for NCSS in patients with PCNSL and PCNS-DLBCL (all P < 0.05).ConclusionNon-cancer-specific causes were important competing causes of death in PCNSL patients. More attention is recommended to non-cancer-specific causes of death in the management of PCNSL patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

Chi

Zhou²,

Luo³

et al. 2023

Front. Oncol.

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“…As an essential biological, social, and psychological event, marriage has also been found to be associated with cardiovascular outcomes in multiple cancers ( 21 , 22 ). In our study, unmarried patients had a higher considerable risk of CVD, which was consistent with the result obtained after PSM.…”

Section: Discussionmentioning

confidence: 99%

Competing risk analysis of cardiovascular mortality in multiple myeloma survivors

Chen,

Guo,

Lin

et al. 2023

Transl Cancer Res

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Background The survival of multiple myeloma (MM) patients has significantly improved, and several factors increase the risk of cardiovascular death (CVD) mortality in MM. This study aims to determine the prognostic significance of factors associated with long-term CVD risk in MM survivors. Methods The data of MM survivors whose survival time was longer than 36 months were retrieved from the Surveillance, Epidemiology, and End Result (SEER) database between 2000 and 2015. Cox proportional hazards regressions and competing risk survival analyses were utilized to assess the CVD-associated risk factors. Propensity score matching (PSM) was further conducted to ensure the comparability of cardiovascular risk factors. The nomogram was based on these epidemiological factors to estimate individualized CVD probabilities for MM survivors, and its performance was assessed by Harrell’s concordance index (C-index) and calibration curve. Results A total of 32,528 survivors with MM were enrolled, and 2,061 (6.34%) suffered from CVD. In Cox proportional hazards regressions and competing risk survival analyses, age, period of diagnosis, sex, race, married status, income, chemotherapy, and radiotherapy were the independent risk factors for CVD. After PSM, there was a significant difference in cumulative incidence curves, using a competing-risks method, between the following matched groups: male vs. female group, white vs. non-white group, married vs. unmarried group, income <$75,000 vs. income ≥$75,000 group, chemotherapy vs. non-chemotherapy group, and radiotherapy vs. non-radiotherapy group. The nomogram predicted CVD probabilities with a training C-index of 0.700 and a validation C-index of 0.726. Calibration curves validated that the nomograms could accurately predict the CVD probabilities both in the training and validation group. Conclusions Among MM survivors, the mortality risk of cardiovascular diseases differs with age, sex, period at diagnosis, race/ethnicity, marital status, chemotherapy, and radiotherapy. Our nomograms, based on epidemiological variables, may be used to predict 5-, 10-, and 15-year cardiovascular disease outcomes of MM survivors.

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“…Our results indicate that unmarried patients have a greater likelihood of experiencing CVM than married individuals, as reported in a previous breast cancer research. [ 33 ] A plausible explanation exists for the greater likelihood of emotional support for married patients compared to unmarried patients, while positive social and psychological factors can potentially ameliorate the prognosis of cardiovascular disease. [ 34 ] These findings suggest that unmarried patients with TC may require more psychological support and compassionate care for their management.…”

Section: Discussionmentioning

confidence: 99%

Competing risk analysis of cardiovascular-specific mortality in typical carcinoid neoplasms of the lung: A SEER database analysis

Xing,

Wu,

Zhang

et al. 2023

Medicine

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Cardiovascular mortality (CVM) is a growing concern for cancer survivors. This study aimed to investigate the mortality patterns of individuals with typical carcinoid (TC) tumors, identify independent predictors of CVM, and compare these risk variables with those associated with TC deaths. The Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2019 was utilized for obtaining data on patients with TC. Standardized mortality rates were employed to evaluate the risk of CVM while multivariate competing risk models were used to determine the association between patient characteristics and the probability of CVM or TC-related deaths. Our findings show that TC patients had an increased risk of CVM, with an standardized mortality rates of 1.12 (95% CI:1.01–1.25). Furthermore, we discovered that age at diagnosis, marital status, year of diagnosis, SEER stage, site, year of diagnosis, surgery, radiotherapy, and chemotherapy all contributed independently to the risk of CVM in patients with TC, whereas age at diagnosis, sex, race, SEER stage, site, year of diagnosis, surgery, radiotherapy, and chemotherapy all contributed significantly to TC mortality. Compared to the general population in the United States, patients with TC are significantly more likely to acquire CVM. Timely introduction of cardioprotective treatments is critical for preventing CVM in patients with TC.

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Association of marital status with cardiovascular outcome in patients with breast cancer

Cited by 4 publications

References 45 publications

Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

Competing risk analysis of cardiovascular mortality in multiple myeloma survivors

Competing risk analysis of cardiovascular-specific mortality in typical carcinoid neoplasms of the lung: A SEER database analysis

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