Association of male pattern baldness with angiographic coronary artery disease severity and collateral development

Abstract

ObjectiveWe aimed to investigate whether there is an association between male pattern baldness and angiographic coronary artery disease (CAD) severity and collateral development, which has not been reported previously.MethodsCoronary arteriograms, CAD risk factors, lipid parameters and presence and severity of baldness in 511 male patients were prospectively evaluated. Baldness was classified into five groups. Severity of CAD was evaluated with the Gensini scoring system and collateral development with Rentrop scores.ResultsAlthough subjects with a higher Gensini score had more frequent and severe baldness, they were older than the group with lower Gensini scores. Bald patients had a higher Gensini score when compared with their non-bald counterparts. In univariate analysis, age more than 60, body mass index more than 30, smoking and baldness were predictors of high Gensini scores. In multivariate analysis, only age more than 60, body mass index more than 30 and smoking were independent predictors of a high Gensini score. There were no differences in terms of presence and severity of baldness in subjects with and without adequate collateral development.ConclusionsThere was no relation between presence, severity and age of occurrence of male pattern baldness and Gensini and Rentrop scores, which are important measures of presence and severity of CAD.

Lipid profile in patients with androgenetic alopecia: a meta‐analysis

“…The full text of the remaining 31 articles was reviewed. Among these 31 articles, eight were additionally excluded for the following reasons: two were review articles, three did not directly compare AGA patients with individuals with normal hair,, one was a comparative study among psoriasis patients, and two did not compare lipid markers appropriately . Among the 23 observational studies, 21 had continuous‐type variables and two had dichotomous‐type variables .…”

Association of Baldness with Coronary Artery Disease and Its Severity

“…In total, some studies could find similar findings, and some others expressed contradictory results. In a study by Sari et al [ 16 ], patients with baldness had a higher Gensini score when compared with their non-bald counterparts; however, in their multivariate analysis, only older age, obesity, and smoking were independent predictors of a high Gensini score. We showed that smoking and hypertension are important risk factors for CAD.…”

“…Moreover, we only used the number of involved coronary vessels as a variable for CAD severity that may not be a good indicator of CAD severity. In this regard, several studies used the criteria, which considered the extension of coronary atherosclerosis, such as Gensini score [ 16 ]. In total, some studies could find similar findings, and some others expressed contradictory results.…”

“…Some previous studies showed a positive association between baldness and CAD when controlling for CAD risk factors [ 11 - 13 ]. However, some other studies showed no association, but these did not control for CAD risk factors [ 14 - 16 ]. The results of the two cohort studies [ 17 , 18 ] were inconclusive.…”

Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study

“…The study from Herrera et al (1995) reported that the extend of baldness was not associated with CHD mortality, however, the amount of progression of baldness was associated with CHD mortality (RR [95%CI]; moderate progression (1.7 [1.0–2.8]) and rapid progression (3.8 [1.9–7.7])) [33]. To better understand the pathophysiology of CHD, Sari et al (2015) investigated the association between MPB and angiographic CAD severity and collateral development, concluding no relation between them [34]. Moreover, our data indicated an increase in log(CAC+1) values in all baldness subgroups compared to ‘no baldness’.…”