Lipid profile in patients with androgenetic alopecia: a meta‐analysis

Kim, M.W.; Shin, In-Soo; Yoon, Hyun Sun; Cho, Soyun; Park, Hyun Sun

doi:10.1111/jdv.14000

Cited by 33 publications

(32 citation statements)

References 62 publications

(141 reference statements)

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“…Although the role of lipids in the skin permeability barrier is well established (92, 93), there are no studies to date to investigate if lipids are crucial for HFSCs activation. Previously, lipid profiles in human patients with alopecia demonstrate abnormal lipid contents (94), suggesting that drugs targeting lipid metabolic enzymes may be beneficial in the treatment of alopecia. While we uncover here a small branch of lipid metabolism downstream of Runx1 via Scd1 and Soat1, many of our Runx1 targets with predicted lipid metabolism functions remain unexplored.…”

Section: Discussionmentioning

confidence: 99%

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

et al. 2018

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The role of lipid metabolism in epithelial stem cell (SC) function and carcinogenesis is poorly understood. The transcription factor Runx1 is known to regulate proliferation in mouse epithelial hair follicle (HF) SCs in vivo and in several mouse and human epithelial cancers. We found a novel subset of in vivo Runx1 HFSC target genes related to lipid metabolism and demonstrated changes in distinct classes of lipids driven by Runx1. Inhibition of lipid-enzymes Scd1 and Soat1 activity synergistically reduces proliferation of mouse skin epithelial cells and of human skin and oral squamous cell carcinoma cultured lines. Varying Runx1 levels induces changes in skin monounsaturated fatty acids (e.g., oleate, a product of Scd1) as shown by our lipidome analysis. Furthermore, varying Runx1 levels, the inhibition of Scd1, or the addition of Scd1-product oleate, individually affects the plasma membrane organization (or fluidity) in mouse keratinocytes. These factors also affect the strength of signal transduction through the membranes for Wnt, a pathway that promotes epithelial (cancer) cell proliferation and HFSC activation. Our working model is that HFSC factor Runx1 modulates the fatty acid production, which affects membrane organization, facilitating signal transduction for rapid proliferation of normal and cancer epithelial cells. Stem Cells 2018;36:1603-1616.

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Section: Discussionmentioning

confidence: 99%

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

et al. 2018

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“…One of the possible explanations for this association, also pointed out by the authors, is an altered peripheral sensitivity to androgens. The most thoroughly studied metabolic pathway in AGA is peripheral conversion of testosterone to dihydrotestosterone (DHT), catalysed by the enzyme 5α‐reductase.…”

mentioning

confidence: 57%

“…The meta‐analysis by Kim and co‐workers, in this issue of JEADV, provides comprehensive investigation of 19 observational studies comparing the serum concentration of different lipid markers in patients with AGA and healthy individuals. This analysis shows that patients with AGA have an atherogenic lipid profile.…”

mentioning

confidence: 99%

Dyslipidemia in patients with androgenetic alopecia. Statins, finasteride or both?

Rudnicka

Rakowska

2017

Acad Dermatol Venereol

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“…A relationship between disorders in lipid metabolism and androgenetic alopecia was confirmed in two metaanalyses. Patients with androgenetic alopecia are found to have an increased concentration of total cholesterol, triglycerides, and cholesterol LDL fractions (low density lipoprotein) considerably more often than the general population [9,24]. Simultaneously, these patients have a decreased concentration of cholesterol HDL fraction (high density lipoprotein), which physiologically shows anti-atherogenic qualities [9,24].…”

Section: Nadciśnienie Tętniczementioning

confidence: 99%

“…Związek między zaburzeniami gospodarki lipidowej a łysieniem androgenowym potwierdzono w dwóch metaanalizach. U pacjentów z łysieniem androgenowym znacznie częściej niż w populacji ogólnej stwierdza się zwiększone stężenie cholesterolu całkowitego, trójglicerydów oraz frakcji LDL cholesterolu (lipoprotein o niskiej gęstości) [9,24]. Jednocześnie dochodzi u nich do zmniejszenia stężenia frakcji HDL cholesterolu (lipoprotein o wysokiej gęstości), który fizjologicznie ma właściwości antyaterogenne [9,24].…”

Section: Insulin Resistanceunclassified

Androgenetic alopecia as a cardiovascular risk factor

Wernicka¹,

Wyzgał²,

Waśkiel‐Burnat³

et al. 2018

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Androgenetic alopecia is the most common cause of chronic hair loss. The first reports indicating the relationship between androgenetic alopecia and cardiovascular diseases were published in the 1970s. Epidemiological studies confirmed a more frequent occurrence of ischaemic heart disease, development of atherosclerosis and an increased risk of cardiovascular death in this group of patients. Metabolic syndrome and the presence of its components: arterial hypertension, dyslipidemia, insulin resistance and visceral obesity are more frequent in androgenetic alopecia. The pathomechanism of co-occurring androgenetic alopecia and cardiovascular diseases includes several factors such as genetic (increased sensitivity to androgens and activity of 5α-reductase), hormonal (increased concentration of insulin, aldosterone, leptin) and inflammatory (cytokines, free oxygen radicals). Androgenetic alopecia, especially when it begins before the age of 30, has been identified as an independent cardiovascular risk factor. Women and men with pattern hair loss should be closely monitored for other risk factors to start prophylaxis. streszczenie Łysienie androgenowe stanowi najczęstszą przyczynę utraty włosów u kobiet i mężczyzn. W latach 70. XX wieku pojawiły się pierwsze doniesienia wskazujące na związek łysienia androgenowego z chorobami układu krążenia. Późniejsze badania epidemiologiczne potwierdziły częstsze występowanie w tej grupie pacjentów choroby niedokrwiennej serca, przyspieszony rozwój miażdżycy oraz większe ryzyko zgonu z przyczyn sercowo-naczyniowych. U osób z łysieniem androgenowym częściej stwierdza się zespół metaboliczny oraz obecność jego poszczególnych składowych, takich jak nadciśnienie tętnicze, dyslipidemia, insulinooporność i otyłość trzewna. Patomechanizm współwystępowania łysienia androgenowego i chorób sercowo-naczyniowych jest złożony i obejmuje czynniki genetyczne (zwiększona wrażliwość na androgeny i aktywność 5α-reduktazy), hormonalne (zwiększone stężenie insuliny, aldosteronu, leptyny) oraz zapalne (cytokiny, wolne rodniki tlenowe). Łysienie androgenowe, zwłaszcza rozpoczynające się przed 30. rokiem życia, uznano za niezależny czynnik ryzyka sercowo-naczyniowego. Kobiety i mężczyźni z androgenową utratą włosów powinni być okresowo monitorowani w celu poszukiwania innych czynników ryzyka, aby jak najszybciej rozpocząć działania profilaktyczne.

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Lipid profile in patients with androgenetic alopecia: a meta‐analysis

Abstract: AGA patients showed statistically significant abnormal lipid profiles, and this might partly explain the association between AGA and cardiovascular diseases.

Cited by 33 publications

References 62 publications

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

Dyslipidemia in patients with androgenetic alopecia. Statins, finasteride or both?

Androgenetic alopecia as a cardiovascular risk factor

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