Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease

Ikonomidis, Ignatios; Kadoglou, Nikolaos P.E.; Tritakis, Vlassis; Paraskevaidis, Ioannis; Dimas, Kostas; Trivilou, Paraskevi; Papadakis, Ioannis; Tzortzis, Stavros; Triantafyllidi, Helen; Parissis, John; Anastasiou-Nana, Maria; Lekakis, John

doi:10.1016/j.atherosclerosis.2014.02.004

Cited by 40 publications

(42 citation statements)

References 38 publications

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“…Elevated cfPWV values are a risk factor for these disorders, suggesting a close relationship between large artery stiffness, reflected by cfPWV, and microvascular changes. In a recent publication by Ikonomidis and colleagues, arterial stiffness, quantified by pulse wave velocity, was identified as a valid marker of atherosclerosis and was associated with impaired coronary flow reserve and CAD.…”

Section: Discussionmentioning

confidence: 99%

Carotid to Femoral Pulse Wave Velocity Reflects the Extent of Coronary Artery Disease

Hofmann

Riemer

Erbs

et al. 2014

J of Clinical Hypertension

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Arterial stiffness is a well‐established risk factor for cardiovascular disease and mortality. Carotid to femoral pulse wave velocity (cfPWV) as a measure of arterial stiffness was obtained in 155 (47 women; 67.2±9.1 years, range 44–87 years) patients with detected coronary artery disease (CAD) scheduled for coronary artery bypass surgery. The authors set out to analyze how cfPWV in CAD patients correlates with reference values for healthy, normotensive volunteers and whether cfPWV values reflect the extent of CAD. cfPWV was measured with an oscillometric device. Mean cfPWV value of CAD patients was 9.3±1.9 m/s vs 7.7±1.1 m/s in healthy volunteers (P<.0001). In a multiple regression model, age (P<.0001), sex (P=.006), systolic arterial pressure (P=.04), mean arterial pressure (P=.04), and severity of CAD (P<.001) emerged as independent predictive markers for cfPWV in CAD patients. This study established reference values for cfPWV in CAD patients measured with an oscillometric device and confirmed the strong association between arterial stiffness and severity of CAD.

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Section: Discussionmentioning

confidence: 99%

Carotid to Femoral Pulse Wave Velocity Reflects the Extent of Coronary Artery Disease

Hofmann

Riemer

Erbs

et al. 2014

J of Clinical Hypertension

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show abstract

“…When data were missing or results for continuous value of FMD or Ln_RHI were not reported, the original authors were contacted in an attempt to obtain these data. One study reported risk estimates for RHI . We contacted and asked the authors to transform RHI results to logarithmic value and obtained results with Ln_RHI.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis

Matsuzawa

Kwon

Lennon

et al. 2015

JAHA

441

334

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BackgroundEndothelial dysfunction plays a pivotal role in cardiovascular disease progression, and is associated with adverse events. The purpose of this systematic review and meta‐analysis was to investigate the prognostic magnitude of noninvasive peripheral endothelial function tests, brachial artery flow‐mediated dilation (FMD), and reactive hyperemia–‐peripheral arterial tonometry (RH‐PAT) for future cardiovascular events.Methods and ResultsDatabases of MEDLINE, EMBASE, and the Cochrane Library were systematically searched. Clinical studies reporting the predictive value of FMD or RH‐PAT for cardiovascular events were identified. Two authors selected studies and extracted data independently. Pooled effects were calculated as risk ratio (RR) for continuous value of FMD and natural logarithm of RH‐PAT index (Ln_RHI) using random‐effects models. Thirty‐five FMD studies of 17 280 participants and 6 RH‐PAT studies of 1602 participants were included in the meta‐analysis. Both endothelial function tests significantly predicted cardiovascular events (adjusted relative risk [95% CI]: 1% increase in FMD 0.88 [0.84–0.91], P<0.001, 0.1 increase in Ln_RHI 0.79 [0.71–0.87], P<0.001). There was significant heterogeneity in the magnitude of the association across studies. The magnitude of the prognostic value in cardiovascular disease subjects was comparable between these 2 methods; a 1 SD worsening in endothelial function was associated with doubled cardiovascular risk.ConclusionsNoninvasive peripheral endothelial function tests, FMD and RH‐PAT, significantly predicted cardiovascular events, with similar prognostic magnitude. Further research is required to determine whether the prognostic values of these 2 methods are independent of each other and whether an endothelial function–guided strategy can provide benefit in improving cardiovascular outcomes.

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“…The role of Lp-PLA 2 activity as a target for pharmaceutical intervention was cast in doubt after publication of the Integrated Biomarker and Imaging Study 2, a randomized placebo controlled phase II trial which found no benefit with the Lp-PLA 2 inhibitor darapladib in reducing major adverse cardiac events in patients with an ACS (21). Ikonomidis et al suggested a prognostic role for Lp-PLA 2 in chronic CAD subjects and attributed the same to potentially detrimental effects of the enzyme on endothelial function and arterial wall properties (22). Yang et al reported initial evidence of role of Lp-PLA 2 in endothelial dysfunction in an in vitro model of atherosclerosis, by regulating the expression of AMP-activated protein kinase (AMPK) that is a potential therapeutic target for improving endothelial function (23).…”

Section: Role Of Lp-pla 2 In Cadmentioning

confidence: 99%

The role of Lp-PLA2 and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians: a case-control study

Sairam

Sola

Barooah

et al. 2017

Cardiovasc. Diagn. Ther.

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Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease

Cited by 40 publications

References 38 publications

Carotid to Femoral Pulse Wave Velocity Reflects the Extent of Coronary Artery Disease

Carotid to Femoral Pulse Wave Velocity Reflects the Extent of Coronary Artery Disease

Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis

The role of Lp-PLA2 and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians: a case-control study

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