Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis

Matsuzawa, Yasushi; Kwon, Taek Geun; Lennon, Ryan J.; Lerman, Lilach O.; Lerman, Amir

doi:10.1161/jaha.115.002270

Cited by 420 publications

(352 citation statements)

References 59 publications

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“…In addition, reductions of 1 mmol in LDL-cholesterol have been associated with a 23% reduction in myocardial infarction or coronary death and 12% reduction in all-cause mortality [39]. In relation with our findings on FMD, several recent systematic reviews and metaanalysis indicate that increases in FMD of 1% increase, independently of confounding factors, are associated with reductions ranging from 10-13% in the risk of cardiovascular events [40][41][42].…”

Section: Implications For Health and Future Researchsupporting

confidence: 77%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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Section: Implications For Health and Future Researchsupporting

confidence: 77%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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“…In addition, several lines of evidence have demonstrated that FMD could be used not only as an index of endothelial function but also as a prognostic marker of cardiovascular events 11, 28. Recent meta‐analyses have shown that FMD is a significant predictor of cardiovascular events independent of conventional cardiovascular risk factors 12, 13, 14. However, there have been very few studies in which the predictive value of FMD in patients with established CAD was investigated 29, 30.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, vascular function tests could be used not only as markers of atherosclerosis but also as prognostic markers of cardiovascular events 11. Recent meta‐analyses have shown that flow‐mediated vasodilation (FMD), an index of endothelial function, and brachial–ankle pulse wave velocity (baPWV), an index of arterial stiffness, are significant predictors of cardiovascular events independent of conventional cardiovascular risk factors 12, 13, 14, 15, 16. However, there have only been a few studies in which the predictive values of FMD, baPWV, and a combination of FMD and baPWV in patients with established CAD were investigated.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A

Maruhashi

Soga

Fujimura

et al. 2018

JAHA

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BackgroundThe usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known.Methods and ResultsWe measured flow‐mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow‐up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver‐operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed.ConclusionsIn patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification.Clinical Trial Registration URL: http://www.umin.ac.jp. Unique identifier: UMIN000012950.

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“…[22][23][24] In 3,026 subjects free of cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA), followed for 5 years, each SD increase in FMD conferred a hazard ratio of 0.84 for incident cardiovascular events. Importantly, FMD also improved net reclassification of risk when compared with the Framingham risk score.…”

Section: Endothelial Function and Adverse Cardiovascular Outcomesmentioning

confidence: 99%

Endothelial Dysfunction and Essential Hypertension

Khambhati¹,

Lee²,

Kindya³

et al. 2017

Hypertension Journal

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Systemic hypertension is a chronic disorder of cardiovascular system characterized by an increase in systemic vascular resistance (SVR). Although the level of blood pressure is a product of SVR and cardiac output, it is the former which is responsible for chronic blood pressure elevation. A number of biochemical, biophysical, and neuro-humoral factors participate in the maintenance of SVR. Whatever the underlying molecular mechanism may be for elevated SVR, the end consequence is endothelial dysfunction. Normal endothelium promotes vasodilation and prevention of local thrombotic phenomena whereas abnormal endothelium promotes vasoconstriction and thrombotic processes. One of the basic pathophysiological aberrations in hypertension is abnormal endothelial function. A number of blood pressure lowering strategies (life-style modification and or anti-hypertensive drugs) result in reversing endothelial dysfunction in hypertension. Thus, endothelial function is considered both as a mechanism and a therapeutic target in hypertension. This review summarizes the physiology and pathophysiology of endothelium in hypertension.

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Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis

Cited by 420 publications

References 59 publications

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A

Endothelial Dysfunction and Essential Hypertension

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