Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease

Biswas, Santanu; Ghoshal, Pradip K.; Mandal, Soumendra Nath; Mandal, Nripendranath

doi:10.1016/j.jjcc.2008.06.005

Cited by 15 publications

(12 citation statements)

References 30 publications

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“…However, contrary to our conclusion, Nansseu et al [ 18 ] found AIP may not be an independent factor impacting the risk of CVD through a cross-sectional study conducted among 108 postmenopausal women in Cameroon. At the same time, atherogenic lipoproteins that have been identified, the high apoliprotein B, low apolipoprotein A-1 and the high ratio of apoB: apoA1 also affect the formation and progression of coronary atherosclerosis [ 31 , 32 ]. In our study, we also find an increased ratio of apoB: apoA1 value was a highly significant risk factor of CAD independent of smoking, hypertension, and diabetes.…”

Section: Discussionmentioning

confidence: 99%

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

et al. 2018

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BackgroundDyslipidemia is one of the most important factors for coronary artery disease (CAD). Atherogenic index of plasma (AIP) is a novel indicator involved in dyslipidemia. However, the relation between AIP and CAD in postmenopausal women remains unclear. We hypotheses that AIP is a strong predictive indicator of CAD in postmenopausal women.MethodsA propensity score matching case–control study including 348 postmenopausal CAD cases and 348 controls was conducted in the present study.ResultsCompared with controls, CAD patients had higher levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (APOB), but lower high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (APOA-1). The values of nontraditional lipid profiles, including non-HDL-C, TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C (atherogenic index, AI), TC∗TG∗LDL/HDL-C (lipoprotein combine index, LCI), log(TG/HDL-C) (atherogenic index of plasma, AIP) and APOB/APOA-1 were all significantly higher in the CAD patients. The results of Pearson correlation analyses showed AIP was positively and significantly correlated with TC (r = 0.092, P < 0.001), TG (r = 0.775, P = 0.015), APOB (r = 0.140, P < 0.001), non-HDL-C (r = 0.295, P < 0.001), TC/HDL-C (r = 0.626, P < 0.001), LDL-C/HDL-C (r = 0.469, P < 0.001), AI (r = 0.626, P < 0.001), LCI (r = 0.665, P < 0.001), APOB/APOA-1(r = 0.290, P < 0.001) and was negatively correlated with APOA-1 (r = − 0.278, P < 0.001) and HDL-C (r = − 0.665, P < 0.001). In the multivariate logistic regression analysis, AIP was an independent predictor of CAD. After adjusting for the traditional clinical prognostic factors including diabetes and hypertension, we found AIP could be an independent risk factor for CAD (odds ratio [OR], 3.290; 95% confidence interval [CI], 1.842–5.877, P < 0.001). After adjusting for multiple clinical factors include diabetes, hypertension, smoking, heart ratio, fasting blood glucose, we found AIP also could a powerful risk factor, OR = 3.619, 95%CI (2.003–6.538), P < 0.001.ConclusionThe present study indicated that AIP might be a strong marker for predicting the risk of CAD in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

et al. 2018

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“…41,42 There is currently a lack of specific treatment options for low HDL-C and elevated TG due to a lack of efficacy data. Lipid medications that specifically target TGs and HDL-C, such as fibrates and niacin, have demonstrated a reduction of CVD events in some trials but not in many others.…”

Section: Discussionmentioning

confidence: 99%

Racial/Ethnic Differences in Dyslipidemia Patterns

et al. 2014

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BACKGROUND No studies have comprehensively examined the prevalence of dyslipidemia, a major risk factor for cardiovascular disease, among diverse racial/ethnic minority groups. The primary aim of this study was to identify racial/ethnic differences in dyslipidemia among minorities including Asian Americans (Asian Indian, Chinese, Filipino, Japanese, Korean or Vietnamese), Mexican Americans, and African Americans compared to Non-Hispanic Whites (NHWs). METHODS AND RESULTS Using a three-year cross-section (2008–2011), we identified 169,430 active primary care patients (35 years or older) from an outpatient health care organization in Northern California. Age-standardized prevalence rates were calculated for three dyslipidemia subtypes: high TG (fasting lab ≥150 mg/dL), low HDL-C (fasting lab <40 [men] and <50 [women] mg/dL), and high LDL-C (fasting lab ≥130 mg/dL or taking LDL-lowering agents). Odds ratios were calculated using multivariable logistic regression, adjusting for patient characteristics (age, measured BMI, smoking). Compared to NHWs, every minority subgroup had increased prevalence of high TGs, except African Americans. Most minority groups had increased prevalence of low HDL-C, except for Japanese and African Americans. The prevalence of high LDL-C was increased among Asian Indians, Filipinos, Japanese, and Vietnamese, compared to NHWs. CONCLUSIONS Minority groups, except for African Americans, were more likely to have high TG/low HDL-C dyslipidemia. Further research is needed to determine how racial/ethnic differences in dyslipidemia affect racial/ethnic differences in cardiovascular disease rates.

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“…Rodriguez et al [ 8 ]) alarmingly found that two-thirds of the Hispanic US population studied exhibited some form of dyslipidemia, with the highest incidence above 40 years of age. The high-triglyceride/low HDL-C dyslipidemia profile, which is described as atherogenic and linked to the metabolic syndrome, is particularly prevalent in this group [ 3 , 8 – 10 ]. In Mexico, the prevalence of dyslipidemias is also very high: a study based on the Mexican National Health and Nutrition Survey (ENSANUT 2006) indicated that the prevalence of total cholesterol concentrations ≥200 mg/dl was 43.6%, and the figures for LDL cholesterol ≥130 mg/dl, HDL cholesterol <40 mg/dl and triglycerides ≥150 mg/dl were 46%, 60,5% and 31.5%, respectively [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

et al. 2017

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We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30–40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.

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Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease

Abstract: Findings from the multivariate analysis, apoB, apoB/HDL-c, nonHDL-c, apoB/apoAI, and LDL particle size are potent indicators and useful for diagnosis of predisposed CHD.

Cited by 15 publications

References 30 publications

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women

Racial/Ethnic Differences in Dyslipidemia Patterns

Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

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