Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men

Lepper, Philipp M.; Schümann, Christian; Triantafilou, Kathy; Rasche, Franz Maximilian; Schuster, Tibor; Frank, Hedwig; Schneider, E. Marion; Triantafilou, Martha; Eynatten, Maximilian von

doi:10.1016/j.jacc.2007.02.070

Cited by 82 publications

(72 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This threshold named 'metabolic endotoxemia' may trigger toll-like receptor 4-mediated inflammatory activation, eliciting a chronic low-grade proinflammatory and pro-oxidative stress status associated with obesity and many of its associated complications [36][37]. Along with the mounting evidence to indicate that gut microbiota is responsible for systemic inflammation, circulating LBP has been found to be increased in ASCVD [39]. In our study, we observed that patients with preexisting ASCVD have higher concentrations of serum LBP.…”

Section: Discussionsupporting

confidence: 48%

Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients

Lim

Chang

2018

Blood Purif

View full text Add to dashboard Cite

Background: In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation. Lipopolysaccharide-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by microbial products. Our aim is to investigate the relationship between circulating levels of LBP, and various metabolic and inflammatory markers in HD patients. Besides, we also aim to determine its relationship among patients with different body mass index. Patients and Methods: A total of 123 HD patients were stratified into three tertiles, according to serum LBP level. The LBP and inflammatory markers were determined using immunoassay methods. A bioimpedance spectroscopy device was used for body composition measurement. Results: The serum levels of the two proinflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6, were significantly higher in patients in the upper tertile when compared with the rest of the tertiles. In HD patients, a significant positive correlation was found between serum LBP levels and CRP, IL-6, soluble CD14 (sCD14), and fasting blood glucose levels. Patients with metabolic syndrome and pre-existing cardiovascular disease had higher LBP levels than those without metabolic syndrome. Besides, obese patients were also associated with higher serum LBP levels. Multivariate regression analyses showed that IL-6 level was the strongest correlate of LBP level, followed by hsCRP level and sCD14. Conclusions: Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. In addition, increased LBP level was correlated positively to markers of inflammation, and sCD14 levels.

show abstract

Section: Discussionsupporting

confidence: 48%

Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients

Lim

Chang

2018

Blood Purif

View full text Add to dashboard Cite

show abstract

“…( 76 ). Several clinical studies have observed a correlation between plasma LBP and atherosclerosis, with the presumption that LBP is a nonspecifi c marker of chronic infl ammation similar to other acute phase proteins such as CRP ( 46,77 ). Unlike CRP however, which showed no effect on atherosclerosis progression in independent transgenic mouse models ( 78,80 ), we show that LBP possesses distinct atherogenic actions.…”

Section: Discussionmentioning

confidence: 58%

The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis

Sallam

Ito

Rong

et al. 2014

Journal of Lipid Research

View full text Add to dashboard Cite

“…LBP co-purifies with high-density lipoprotein (HDL) particles and additional studies have shown that LBP can transfer LPS to lipoproteins, neutralizing LPS effects. 13 Serum LBP concentration was described as a marker of coronary artery disease 14,15 and has been recently found to be associated with obesity and related disorders in apparently healthy Chinese subjects. 16 We here confirm the previously reported association of circulating LBP with insulin resistance and obesity in a Caucasian population.…”

Section: Introductionmentioning

confidence: 99%

Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

et al. 2011

View full text Add to dashboard Cite

OBJECTIVE: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n ¼ 222) and weight loss-induced (n ¼ 34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. RESULTS: Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 mg ml À1 , Po0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. CONCLUSION: LBP is an inflammatory marker associated with obesity-related insulin resistance.

show abstract

Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men

Cited by 82 publications

References 41 publications

Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients

Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients

The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis

Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

Contact Info

Product

Resources

About