Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study

Abstract

OBJECTIVE-The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.STUDY DESIGN-Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.RESULTS-Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.CONCLUSION-Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications. Keywords adverse outcomes; gestation; lipidsA number of diseases affecting the cardiovascular system emerge during pregnancy. Gestational diabetes mellitus is a risk factor for the development of type 2 diabetes and gestational hypertension is associated with an elevated risk for developing subsequent systemic hypertension. 1-3 Gestational diabetes and hypertension can contribute to maternal and fetal risk of developing peri-and postpartum complications. 4,5 Reprints: Victor Novack, MD, PhD,

Short Communication The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

“…GDM patients were reported to be associated with older age, higher BMI, hypertension, and increased levels of the lipid profile, especially triglycerides, when compared to healthier pregnant women (Langer et al, 2005;Wiznitzer et al, 2009). So, the characteristics of the studied population presented in Table 1 were similar to other studies.…”

Early predictors of PIH: serum beta-HCG and lipid profile

“…So almost all the 14 women developed PIH which is comparable with the meta analysis study published in BJOG by Gallos et al and Amar lal et al 5,6 Abnormal levels of TG is associated with pregnancy complication. 7 The raised TG level increased atherogenic LDL concentration. The mean LDL Cholesterol and TG levels were significantly higher in the women who are likely to develop preeclampsia in future.…”

The Argentinian mother-and-child contaminant study: a cross-sectional study among delivering women in the cities of Ushuaia and Salta

“…Potential relationships of PTS to the clinical chemistry parameters measured are anticipated, such as the association of OCs with circulating hormones such as estradiol [28,29] and the influence of reduced maternal lipid concentrations post-partum [30,31], as well as factors that can enhance the uptake of inorganic elements, such as low iron status [25]. Associations of the maternal body burdens of organochlorine and inorganic toxicants with birth weight, birth length and gestational age of the newborns will also be examined.…”