Association of Lipid and Body Mass Index Profile With Chronic Hepatitis C Infection Stratified by Age and Gender

Abstract

Background In this study, we aimed to determine the association of lipid and body mass index (BMI) profiles among cases having chronic hepatitis C virus (CHCV) infection. Methodology This cross-sectional study was conducted in the outpatient department of a tertiary care hospital. A total of 320 cases of both genders, aged 18 to 60 years, with CHCV infection were enrolled in the study. After obtaining relevant history and conducting a physical examination, the venous blood sample of each patient was taken and sent to the institutional laboratory to analyze serum total cholesterol, serum triglyceride, low-density lipoprotein, and high-density lipoprotein levels. BMI of all the study participants was also noted. Results Of the total 320 cases, there were 152 (47.5%) males and 168 (52.5%) females. The overall mean age was 42.92 ± 11.38 years. Most cases [97 (30.3%)] were in the 41 to 50-year age group. Overall, the mean BMI was 27.75 ± 4.59 kg/m 2 . Dyslipidemia was noted in 144 (45.0%) cases. Increasing age and increasing BMI were found to have statistical significance with the presence of dyslipidemia (p < 0.05). Conclusions Increasing age and BMI have a significant association with dyslipidemia in patients with CHCV infection. Lipid profile appears to differ among different age and BMI groups.

Features of clinical, biochemical, and sonographic parameters in patients with chronic viral hepatitis C with concomitant non-alcoholic fatty liver disease

“…From a study by Maqsood et al in Pakistan among 320 adults with hepatitis C, 45.0% were diagnosed with dyslipidemia. At the same time, together with the presence of dyslipidemia, age and increase in BMI were shown to be statistically significant [35]. According to researchers in Mexico [36], lipid profile disorders in patients with hepatitis C can contribute to liver steatosis and excessive lipid deposition in hepatocytes According to researchers in Croatia [37], severe HCV infection affects the severity and progression of liver fibrosis, insulin resistance, and lower response rates to interferon therapy, and also contributes to the development of hepatocellular carcinoma (HCC).…”

Seroprevalence of Hepatitis B Virus and Hepatitis C Virus in Patients Undergoing Maintenance Hemodialysis

“…Most of the patients (90%) recover from the acute infection by forming neutralizing antibodies, and the rest of the patients develop chronic hepatitis B [ 1 ]. Similarly, HCV infection also manifests as both acute and chronic hepatitis C. Most cases develop a chronic infection that leads to cirrhosis, hepatocellular carcinoma, cardiovascular disorders, and neurological manifestation like hepatic encephalopathy [ 12 , 13 ]. Moreover, hemodialysis patients suffer from anxiety and depression, which can be exacerbated by this infection, leading to increased morbidity and mortality [ 14 ].…”