Association of LINC00673 Genetic Variants with Progression of Oral Cancer

Abstract

Oral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (LINC00673) have been currently connected to the predisposition to various cancer types. The present study attempted to explore the impact of LINC00673 gene polymorphisms on the risk and progression of OSCC. Three LINC00673 single-nucleotide polymorphisms (SNPs), including rs11655237, rs9914618, and rs6501551, were evaluated in 1231 OSCCC cases and 1194 cancer-free controls. We did not observe any significant association of three individual SNPs with the risk of OSCC between the case and control group. However, while assessing the clinicopathological parameters, patients carrying at least one minor allele of rs9914618 (GA and AA; OR, 1.286; 95% CI, 1.008–1.642; p = 0.043) were found to develop lymph node metastasis more often compared to those who are homozygous for the major allele. Further stratification analyses revealed that this genetic correlation with increased risk of lymphatic spread was further fortified in habitual betel quid chewers (OR, 1.534; 95% CI, 1.160–2.028; p = 0.003) or smokers (OR, 1.320; 95% CI, 1.013–1.721; p = 0.040). Moreover, through analyzing the dataset from The Cancer Genome Atlas (TCGA), we found that elevated LINC00673 levels were associated with the development of large tumors in patients with head and neck squamous cell carcinoma and the risk of lymphatic spread in smokers. These data demonstrate a joint effect of LINC00673 rs9914618 with betel nut chewing or smoking on the progression of oral cancer.

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

“…A total of three LINC00673 SNPs, namely, rs6501551 (A/G), rs9914618 (G/A), and rs11655237 (C/T), were selected for phenotype analyses because the minor allele frequencies of these SNPs were higher than 5% and our preceding research indicated the effect of these SNPs on other cancers ( Su et al, 2021a ). The procedures for DNA extraction and phenotype analyses in this study were in accordance with those of our previous study ( Su S. C. et al, 2018 ).…”

“…Among this group, long intergenic noncoding RNA 00673 (LINC00673) is associated with several malignancies ( Zhu K. et al, 2021 ; Zhu Y. et al, 2021 ). In addition, LINC00673 SNPs can influence the expression of cancers such as oral cancer and gastric cancer ( Zhao et al, 2019 ; Su et al, 2021a ). Nevertheless, research on the relationship between the SNPs of LINC00673 and DR development is rare.…”

Association of KMT2C Genetic Variants with the Clinicopathologic Development of Oral Cancer

“…Furthermore, sexually transmitted diseases, such as HPV-mediated (p16) [ 8 ], are also associated with oral cancer. However, genome-wide and targeted-gene association studies [ 9 , 10 ] have found relationships between single-nucleotide polymorphisms and carcinogenesis.…”

Advances in Personalized Medicines along with Functional Genomics and Pharmacogenomics

“…This Special Issue, Functional Genomics and Pharmacogenomics in Human Disease, covers 15 publications conducted by various groups, including nine original research papers, five review papers, and one case report. Original research papers consist of genetic discovery and functional characterization of CYP1A2 and CYP2C9 [ 1 , 2 ], genetic studies of oral cancer [ 3 , 4 , 5 ], chronic obstruction pulmonary disease (COPD) [ 6 ], asthma [ 7 ], diabetic kidney disease [ 8 ], and web-based pharmacogenomics tool development [ 9 ]. Review papers include the thiopurine treatments with NUDT15 polymorphisms [ 10 ], lipid lowering therapies in familial hypercholesterolemia [ 11 ], incorporation of genetic addiction risk severity (GARS) to overcome the addiction pandemic [ 12 ], and the latest update on genetic variants of UGT [ 13 ] and SULT genes [ 14 ].…”

“…Oral cancer research was conducted with genetics and presented the risk of cancer occurrence, the sensitivity of cancer development, and the degree of cancer progression related to genetic variants. MACC1 [ 3 ], LINC00673 [ 4 ], and IncRNA GASS5 [ 5 ] were investigated, and the correlation between the mutants of these genes and oral cancer was described. If additional genetic variants related to oral cancer are further studied on the present patients, it is expected to provide important information that is very practical for personalized treatment and prevention of oral cancer.…”