Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study

Stringhini, Silvia; Batty, G. David; Bovet, Pascal; Shipley, Martin J.; Marmot, Michael; Kumari, Meena; Tabák, Ádám G.; Kivimäki, Mika

doi:10.1371/journal.pmed.1001479

Cited by 175 publications

(153 citation statements)

References 84 publications

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“…Following a review of the literature, several factors known to relate to either basal or stimulated levels of IL-6 have been selected: age [13], the latest grade of employment derived from the British Civil Service classification (categorized as high, intermediate, low), and total household income (in GBP categorized as <20K, 20-40K, >40K) as an index of socioeconomic position [13,24]. An adiposity component was computed using participants' BMI, waist circumference, and fat mass [10,13].…”

Section: Covariatesmentioning

confidence: 99%

Post-menopausal Women Exhibit Greater Interleukin-6 Responses to Mental Stress Than Older Men

2016

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Background Acute stress triggers innate immune responses and elevation in circulating cytokines including interleukin-6 (IL-6). The effect of sex on IL-6 responses remains unclear due to important limitations of previous studies. Purpose The purpose of this study was to examine sex differences in IL-6 responses to mental stress in a healthy, older (postmenopausal) sample accounting for several moderating factors. Methods Five hundred six participants (62.9 ± 5.60 years, 55 % male) underwent 10 min of mental stress consisting of mirror tracing and Stroop task. Blood was sampled at baseline, after stress, and 45 and 75 min post-stress, and assayed using a high sensitivity kit. IL-6 reactivity was computed as the mean difference between baseline and 45 min and between baseline and 75 min post-stress. Main effects and interactions were examined using ANCOVA models. Results There was a main effect of time for the IL-6 response (F 3,1512 = 201.57, p = <.0001) and a sex by time interaction (F 3,1512 = 17.07, p = <.001). In multivariate adjusted analyses, IL-6 reactivity was significantly greater in females at 45 min (M = 0.37 ± 0.04 vs. 0.20 ± 0.03 pg/mL, p = .01) and at 75 min (M = 0.57 ± 0.05 vs. 0.31 ± 0.05 pg/mL, p = .004) post-stress compared to males. Results were independent of age, adiposity, socioeconomic position, depression, smoking and alcohol consumption, physical activity, statin use, testing time, task appraisals, hormone replacement, and baseline IL-6. Other significant predictors of IL-6 reactivity were lower household wealth, afternoon testing, and baseline IL-6. Conclusions Healthy, post-menopausal females exhibit substantially greater IL-6 responses to acute stress. Inflammatory responses if sustained over time may have clinical implications for the development and maintenance of inflammatoryrelated conditions prevalent in older women.

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Section: Covariatesmentioning

confidence: 99%

Post-menopausal Women Exhibit Greater Interleukin-6 Responses to Mental Stress Than Older Men

2016

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“…4 In addition, people with low SES tend to have higher levels of chronic inflammation. 5 However, the specific biologic mechanisms through which SES affects stress biology and inflammation are not well understood. Epigenetic changes in DNA methylation (DNAm), which give rise to mitotically heritable alterations in gene expression, have recently received attention as one of the biological pathways through which a range of environmental exposures could have sustained effects on many different health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis

et al. 2015

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y Co-first authors. Keywords: DNA methylation, gene expression, inflammation, socioeconomic status, stress reactivityEpigenetic changes, such as DNA methylation, have been hypothesized to provide a link between the social environment and disease development. The purpose of this study was to examine associations between life course measures of socioeconomic status (SES) and DNA methylation (DNAm) in 18 genes related to stress reactivity and inflammation using a multi-level modeling approach that treats DNAm measurements as repeat measures within an individual. DNAm and gene expression were assessed in purified monocytes for a random subsample of 1,264 nonHispanic white, African-American, and Hispanic participants aged 55-94 from the Multi-Ethnic Study of Atherosclerosis (MESA). After correction for multiple testing, we found that low childhood SES was associated with DNAm in 3 stressrelated genes (AVP, FKBP5, OXTR) and 2 inflammation-related genes (CCL1, CD1D), low adult SES was associated with DNAm in one stress-related gene (AVP) and 5 inflammation-related genes (CD1D, F8, KLRG1, NLRP12, TLR3), and social mobility was associated with DNAm in 3 stress-related genes (AVP, FKBP5, OXTR) and 7 inflammation-related genes (CCL1, CD1D, F8, KLRG1, NLRP12, PYDC1, TLR3). In general, low SES was associated with increased DNAm. Expression data was available for 7 genes that showed a significant relationship between SES and DNAm. In 5 of these 7 genes (CD1D, F8, FKBP5, KLRG1, NLRP12), DNAm was associated with gene expression for at least one transcript, providing evidence of the potential functional consequences of alterations in DNAm related to SES. The results of this study reflect the biological complexity of epigenetic data and underscore the need for multi-disciplinary approaches to study how DNAm may contribute to the social patterning of disease.

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“…Néanmoins, la persistance du lien entre environnement socioéconomique précoce et mortalité, même après la prise en compte de facteurs tels que l'environnement pré-et périnatal, les comportements de santé, le statut pondéral [3], interroge sur le rôle d'autres mécanismes, notamment physiologiques. De récentes études ont ainsi montré un lien entre environnement socioéconomique précoce et perturbation de systèmes biologiques à l'âge adulte, tels que les systèmes de réponse au stress (axe hypothalamo-hypophysaire, production de glucocorticoïdes) [4,55], les systèmes inflammatoire et métabolique [5]. Des travaux s'intéressant à des marqueurs plus généraux d'usure physiologique, comme la charge allostatique 1 [6], et de vieillissement, comme la longueur des télomères [7], observent une usure physiologique globale et un vieillissement accélérés chez les personnes exposées à un environnement socioéconomique précoce défavorable.…”

Section: Les Enjeux Liés Aux Modifications Du Statut Nutritionnel Matunclassified

“…L'exposition in utero de souris mâles à des particules de diesel provoque des taux de mutations (touchant les expanded simple tandem repeat (ESTR) DNA loci 5 ) plus élevés par rapport aux souris non exposées [53] et altère la qualité du sperme chez l'adulte [54]. 5 Locus très informatifs pour l'analyse de mutations de lignées germinales spontanées et induites.…”

Section: La Pollution Atmosphériqueunclassified

DOHaD

Delpierre¹,

Lepeule

Cordier

et al. 2016

Med Sci (Paris)

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Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study

Abstract: Silvia Stringhini and colleagues followed a group of British civil servants over 18 years to look for links between socioeconomic status and health. Please see later in the article for the Editors' Summary

Cited by 175 publications

References 84 publications

Post-menopausal Women Exhibit Greater Interleukin-6 Responses to Mental Stress Than Older Men

Post-menopausal Women Exhibit Greater Interleukin-6 Responses to Mental Stress Than Older Men

Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis

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