DOHaD

Delpierre, Cyrille; Lepeule, Johanna; Cordier, Sylvaine; Slama, Rémy; Heude, Barbara; Munier, Charles

doi:10.1051/medsci/20163201005

Cited by 14 publications

(3 citation statements)

References 55 publications

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“…Таким образом, будет очень интересно оценить участие микро-РНК в координации этих различных типов клеток, необходимых для полового созревания и поддержания фертильности. Внутренняя и внешняя среда организма влияет на механизмы эпигенетического контроля, особенно те, в которых задействованы микро-РНК [30][31][32][33][34][35][36][37][38]. Поэтому создание молекулярных основ для модуляции экспрессии miRNA в соответствии с этими внутренними и внешними параметрами (биологические часы, половые гормоны, метаболический контекст, циркадный цикл, воздействие стресса, запахи и т.…”

Section: заключениеunclassified

Micro RNAS as New Players in Control of Hypothalamic Functions

Beylerli

Gareev

Beilerli

2019

Kreativnaâ hirurgiâ i onkologiâ

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Micro RNAs (miRNAs) are short non-coding RNAs (ncRNAs) of ~22 nucleotides in length involved in the post-transcriptional regulation of gene expression. They were discovered over 15 years ago and their functions are becoming clearer. They play an important role in all biological processes. MiRNAs are important modulators of the expression of eukaryotic genes. Focusing on transcripts encoding proteins they impact on the cellular transcriptome thus helping to determine the destiny of a cell. More and more data emerge to indicate an important functional role of miRNAs in the brain development. Since their discovery many miRNAs have been described as key factors in the development and function of the central nervous system. Some play a significant role in the genesis and differentiation of nerve cells (neurons and glial cells). Notably, it has recently been established that miRNAs play a vital role in the mechanisms underpinning the infantile increase of the gonadotropin-releasing hormone (GnRH) production by neurons in the hypothalamus. This phenomenon is necessary for the onset of puberty in mammals. In this review offers our attempt to describe miRNAs as new players in the control of hypothalamic functions, namely the onset of puberty.

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Section: заключениеunclassified

Micro RNAS as New Players in Control of Hypothalamic Functions

Beylerli

Gareev

Beilerli

2019

Kreativnaâ hirurgiâ i onkologiâ

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“…Polluted air thus corresponds to a heterogeneous mixture of chemical compounds in gaseous or particulate form (Delpierre et al 2016). The main gaseous pollutants are nitrogen oxides (NO x ), carbon monoxide and dioxide (CO and CO 2 ), ozone (O 3 ), sulfur dioxide (SO 2 ) and certain Volatile Organic Compounds (VOCs).…”

Section: Introductionmentioning

confidence: 99%

Outdoor Air Pollution in Dakar city (Senegal) and Health Risk Assessment: A pilot study

Daffe,

THIAM,

BAH

et al. 2023

Preprint

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Outdoor air pollution is the underlying cause of 4.2 million premature deaths per year, of which some 18% were due to chronic obstructive pulmonary disease (COPD) and 23% due to acute lower respiratory tract infections (IRI). In West African countries, anthropogenic sources of air pollution are concentrated near residential areas, thus exposing populations to high risks of adverse effects. In order to stimulate the implementation of policies to reduce population exposure, this study aimed to describe outdoor air pollution in Dakar (Senegal) and to estimate its health impact. The description was made by comparing the annual averages of various pollutants (NO2, SO2, PM10 and PM2.5) to guideline values and on the other hand by converting the monthly averages into time-series which trends and seasonality are described using the R software. The impact was estimated with AirQ+ software by calculating the number of specific health outcomes (hospital admissions for respiratory diseases and all-cause mortality) from short-term exposure to outdoor air pollutants’ levels above the threshold of 10 ug/m3. Monthly levels follow a linear trend (except that of NO2), with a seasonal component. Pollution peaks are always observed in the December-January-February quarter, while the lowest levels are observed in the July-August-September quarter. Moreover, the annual levels are all above the guideline values, except for SO2. Between 2016 and 2018, and for all ages combined, 1379 (13.38%) cases of hospital admission for respiratory diseases can be attributed to short-term exposure to PM10. The latter is also the underlying cause of 315 (7.48%) non-accident deaths noted in 2017. Air pollution is a real problem in Dakar in view of the level of indicators. With regard to their health impact, a more exhaustive and more robust estimation would be very useful for better exposure reduction policies. To this end, air quality monitoring and health data management could be improved.

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“…[5][6][7] In recent years, in the current context of high-income countries and following the recent evolution of food consumption, the problem of overweight has become a major public health issue. 8 (Figure 1). Studies increasingly suggest that exposure to obesogenic contaminants may also play a role in the growing risk of obesity, as food is one of the main pathways of exposure to these contaminants.…”

Section: Introductionmentioning

confidence: 99%

Weight Changes, Nutritional Intake, Food Contaminants, and Supplements in Women of Childbearing Age, including Pregnant Women: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives

Lecorguillé

Camier

Kadawathagedara

2022

J Midwife Womens Health

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Adequate maternal nutrition is crucial for a healthy pregnancy and optimal fetal growth. Many women in France of childbearing age start their pregnancy in an unfavorable nutritional status. Recent studies highlight the value of paying attention to weight issues from the preconceptional period. It is important to call attention to the need for folate supplementation and to promote a varied and balanced diet throughout pregnancy to cover essential nutritional needs.

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DOHaD

Cited by 14 publications

References 55 publications

Micro RNAS as New Players in Control of Hypothalamic Functions

Micro RNAS as New Players in Control of Hypothalamic Functions

Outdoor Air Pollution in Dakar city (Senegal) and Health Risk Assessment: A pilot study

Weight Changes, Nutritional Intake, Food Contaminants, and Supplements in Women of Childbearing Age, including Pregnant Women: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives

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