Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

Guo, Jìng; Brickman, Adam M.; Manly, Jennifer J.; Reitz, Christiane; Schupf, Nicole; Mayeux, Richard; Gu, Yian

doi:10.1002/alz.12359

Cited by 31 publications

(53 citation statements)

References 51 publications

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“…Hypertension has been identified as a risk factor for VaD (Joas et al, 2012). Our findings are in line with previous work indicating that the management of hypertension is crucial to the prevention of VaD (Guo et al, 2021). We also determined that younger male MCI patients faced an elevated likelihood of developing dementia, which may be due to the correlation between male sex and VaD, particularly among younger elderly individuals (Liu et al, 1998).…”

Section: Discussionsupporting

confidence: 90%

Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan

Huang

Liu

Liao

et al. 2022

Front. Aging Neurosci.

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IntroductionThere is increasing evidence that arrhythmia is a risk factor for dementia; however, it appears that arrhythmia affects the cognitive function of individuals differentially across age groups, races, and educational levels. Demographic differences including educational level have also been found to moderate the effects of modifiable risk factors for cognitive decline.MethodsThis study recruited 1,361 individuals including a group of cognitively unimpaired (CU) individuals, a group of patients with mild cognitive impairment (MCI), and a group of patients with dementia with low education levels. The participants were evaluated in terms of modifiable risk factors for dementia, including arrhythmia and neuropsychiatric symptoms.ResultsCox proportional hazard regression models revealed that among older MCI patients (>75 years), those with arrhythmia faced an elevated risk of dementia. Among younger MCI patients, those taking anti-hypertensive drugs faced a relatively low risk of dementia. Among younger MCI patients, male sex and higher educational level were associated with an elevated risk of dementia. Among CU individuals, those with coronary heart disease and taking anti-lipid compounds faced an elevated risk of MCI and those with symptoms of depression faced an elevated risk of dementia.DiscussionThe risk and protective factors mentioned above could potentially be used as markers in predicting the onset of dementia in clinical settings, especially for individuals with low educational levels.

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Section: Discussionsupporting

confidence: 90%

Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan

Huang

Liu

Liao

et al. 2022

Front. Aging Neurosci.

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“… 6 The associations of 7 individual components with cognitive outcomes have been widely studied, 7 , 8 , 9 , 10 , 11 , 12 , 13 and a few recent studies have also examined the associations between the adherence of LS7 and cognitive outcomes, and higher score of LS7 are associated with better cognitive outcomes in several domains. 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 However, most of these studies were based on individual cohorts with different characteristics, and it is desirable that the associations are examined in a sample representative of the US population.…”

mentioning

confidence: 99%

Adherence to Life’s Simple 7 and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014

Wei

Wang

Kulshreshtha

et al. 2022

JAHA

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Background The American Heart Association proposed the Life’s Simple 7 (LS7; including diet, physical activity, smoking, body mass index, blood pressure, plasma fasting glucose, total cholesterol) to promote cardiovascular health. Adherence to LS7 has been found to be associated with better cognitive health as well, but the generalizability of previous studies is limited. We aimed to examine the associations of adherence to LS7 and cognitive function among older adults in a nationally representative sample of population. Methods and Results A total of 2585 older adults (≥60 years, 54% female, 80% non‐Hispanic White) in the National Health and Nutrition Examination Survey 2011 to 2014 were included for analysis. Components of LS7 were measured, and adherence to LS7 was calculated on the basis of established cutoff points of individual components. Cognitive function was examined using the Consortium to Establish a Registry for Alzheimer’s Disease Word List Memory Task (immediate and delayed memory), Digit Symbol Substitution Test (DSST), and Animal Fluency Test. Test‐specific and global cognition Z scores were created. Multivariable linear regression models were conducted on the associations of adherence to LS7 with domain‐specific and global cognition Z scores. Each incremental point in adherence to LS7 was associated with higher Z scores for global cognition (β=0.05; 95% CI, 0.02–0.07), Digit Symbol Substitution Test (β=0.05; 95% CI, 0.03–0.07), Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subtest immediate memory (β=0.03; 95% CI, 0.004–0.05), and animal fluency test (β=0.05; 95% CI, 0.02–0.07). Conclusions Greater adherence to LS7 metrics is associated with better cognitive function among older US adults in a nationally representative sample of population.

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“…The population in the current study was relatively younger with intact cognitive function, which could represent the preclinical stage of AD. The correlations between LS7 and dementia and AD risks were verified, and the underlying mechanisms of accumulation of neurodegenerative pathology and the reduction of clearance may be involved in multiple pathways, including vascular risks, inflammatory, oxidative stress, and mitochondrial dysfunction [ 11 , 30 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, research in Rotterdam displayed the protective effects on dementia among low and intermediate genetic risk populations [ 41 ]. Also, significant associations between LS7 scores and composite lifestyles with dementia were observed only among APOE ε4 allele non-carriers, yet not in the carriers [ 11 , 14 ]. The relationship between metabolic risk profile and cognitive performance was suggested stronger among APOE ε4 allele non-carriers [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Zhao

et al. 2022

Alz Res Therapy

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Introduction This study sought to explore the association between Life’s Simple 7 (LS7) and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) pathological biomarkers in the cognitively normal northern Chinese population. Methods From the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study, 1106 cognitively normal participants were enrolled. The mean age was 62.34 years, and 39.6% were female. LS7 scores were summed with each metric assigned 0, 1, or 2 scores. The multiple linear regression models were used to investigate the association between LS7 scores and CSF AD biomarkers. Results We found that LS7 scores were significantly associated with CSF AD pathologies, including Aβ42/40 (β = 0.034, P = .041), p-tau181 (β = − 0.043, P = .006), and t-tau (β = − 0.044, P = .003). In subscales, the biological metrics (blood pressure, cholesterol, glucose) were significantly related to CSF tau-related biomarkers. These associations were observed in the APOE ε4 allele non-carriers, yet not in carriers. The relationship of behavior metrics was found in the middle age and males. Conclusion Improving LS7 scores might do a favor to alleviate the pathology of AD in the preclinical stage, especially among the APOE ε4 allele non-carriers.

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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

Cited by 31 publications

References 51 publications

Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan

Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan

Adherence to Life’s Simple 7 and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014

Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

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