Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Zhao, Yongli; Ou, Ya‐Nan; Ma, Ya‐Hui; Huang, Yu‐Yuan; Bi, Yanlin; Tan, Lan; Yu, Jin‐Tai

doi:10.1186/s13195-022-01019-2

Cited by 11 publications

(8 citation statements)

References 44 publications

(57 reference statements)

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“…Another study discovered that mid-age Framingham Stroke Risk Profile was significantly associated with memory decline [37]. More studies have used LS7 to quantify CVH, and found that higher LS7 protect cognition [8,9,[38][39][40]. LE8 incorporating eight modifiable risk factors and uses a 100-point scale for assessment, providing a more comprehensive and nuanced perspective of CVH evaluation [11].…”

Section: Discussionmentioning

confidence: 99%

Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: the Framingham Heart Study

Yang,

Ding,

et al. 2024

Preprint

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Background: Emerging studies indicate that cardiovascular health (CVH) is a modifiable risk factor for AD. However, studies on how mid-life Life's Essential 8 (LE8) scores affect the AD risk and digital cognitive performance are limited. Objective: To examine the associations between CVH in middle age, as defined by LE8 scores, and subsequent digital cognitive performance and incident AD. Methods: Linear regression and Cox proportional-hazard models were used to examine the associations of mid-age CVH with dCDT performance and incident AD, respectively. Prediction performance of mid-age LE8 scores for incident AD were assessed using ROC curve analysis. Results: Every one-SD increase in mid-age LE8 total score was associated with a 0.16-SD increase in dCDT total score (p < 0.001). Ideal CVH in middle age was associated with higher dCDT scores compared to intermediate CVH. Furthermore, higher mid-age LE8 scores were associated to a decreased risk of AD, with ideal CVH significantly lowering AD risk compared to intermediate CVH. The combination of dCDT performance, mid-age LE8 scores, APOE ε4 status, and other covariates provided the best prediction performance for incident AD, with an AUC of 0.84. Notably, mid-life LE8 scores improved its predictive accuracy by 5.7%. Conclusion: Our findings emphasize the critical role of CVH in middle age as a predictor of both digital cognitive performance and the risk of developing AD, highlighting the importance of early intervention on CVH to delay the progression of cognitive decline. Key Words: Life's Essential 8, Cardiovascular health, Digital cognitive performance, Alzheimer's disease

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Section: Discussionmentioning

confidence: 99%

Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: the Framingham Heart Study

Yang,

Ding,

et al. 2024

Preprint

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“…The discrepancy may be due to the difference of prediction models, measurement bias of Aβ42 and sample size. As a specific markers of AD, p-tau reflects intraneuronal tangles of hyperphosphorylated tau [ 36 , 37 ]. However, t-tau is a nonspecific marker of AD, and it reflects neuronal damage or intensity of degeneration [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study

Yin,

Gao,

et al. 2024

Alz Res Therapy

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Background It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adults, the correlations of ANU-ADRI scores with cerebrospinal fluid (CSF) core biomarkers and cognition remain unclear. Methods Individuals from the Chinese Alzheimer’s Biomarker and LifestyLE (CABLE) study were grouped into three groups (low/intermediate/high risk groups) based on their ANU-ADRI scores. The multiple linear regression models were conducted to investigate the correlations of ANU-ADRI scores with several biomarkers of AD pathology. Mediation model and structural equation model (SEM) were conducted to investigate the mediators of the correlation between ANU-ADRI scores and cognition. Results A total of 1078 non-demented elders were included in our study, with a mean age of 62.58 (standard deviation [SD] 10.06) years as well as a female proportion of 44.16% (n = 476). ANU-ADRI scores were found to be significantly related with MMSE (β = -0.264, P < 0.001) and MoCA (β = -0.393, P < 0.001), as well as CSF t-tau (β = 0.236, P < 0.001), p-tau (β = 0.183, P < 0.001), and t-tau/Aβ42 (β = 0.094, P = 0.005). Mediation analyses indicated that the relationships of ANU-ADRI scores with cognitive scores were mediated by CSF t-tau or p-tau (mediating proportions ranging from 4.45% to 10.50%). SEM did not reveal that ANU-ADRI scores affected cognition by tau-related pathology and level of CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2). Conclusion ANU-ADRI scores were associated with cognition and tau pathology. We also revealed a potential pathological mechanism underlying the impact of ANU-ADRI scores on cognition.

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“…Poor CVH has previously been related to greater white matter hyperintensity volume, silent brain infarcts, lower gray matter perfusion, and lower brain volume, which may mediate the association between CVH and cognitive function [29, 30]. In addition, a recent study showed that LS7 was related to levels of cerebrospinal Alzheimer's disease biomarkers, suggesting a link between better CVH and a lower degree of Alzheimer's disease pathology [31]. Furthermore, poor CVH may increase the risk of dementia by interacting with the β‐amyloid burden or promoting β‐amyloid and tau deposition, the pathological hallmarks of Alzheimer's disease [32–35].…”

Section: Discussionmentioning

confidence: 99%

The age‐dependent association of Life's Simple 7 with transitions across cognitive states after age 60

et al. 2023

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Background. Life's Simple 7 (LS7) aims to promote ideal cardiovascular health (CVH). Its association with different cognitive states in the older old is unclear.Objectives. To assess the associations of LS7 with transitions across normal cognition, cognitive impairment, no dementia (CIND), and dementia and evaluate cognitive impairment-free years of life by LS7-defined CVH levels in older adults.Methods. This cohort study included 2746 participants from the Swedish National Study on Aging and Care in Kungsholmen, regularly examined over 15 years. Total LS7 scores were created and dichotomized into worse and better CVH categories. The associations of LS7 total scores and CVH categories with cognitive states were assessed with multistate models in the whole sample and in younger old (<78 years) and older old adults (≥78 years) separately. Cognitive impairment-free life years by CVH categories were then predicted. Results.A 1-point increment in the LS7 total score was associated with lower dementia risk in younger old adults (hazard ratio: 0.87 [0.78-0.97]) but not in older old adults (1.04 [0.97-1.13]). Better CVH was also associated with a lower risk of transition from normal cognition to CIND (0.76 [0.61-0.95]) and from normal cognition to dementia (0.42 [0.21-0.82]) in younger old adults. In younger old adults, those with better CVH were predicted to have twoto-three more cognitive impairment-free life years than those with worse CVH. Conclusion.Maintaining LS7-defined ideal CVH seems relevant in younger old adults but not in older old adults when considering the potential protective effects against cognitive impairment.

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Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study

Cited by 11 publications

References 44 publications

Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: the Framingham Heart Study

Association of mid-age Life’s Essential 8 score with digital cognitive performance and incident Alzheimer’s disease: the Framingham Heart Study

ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study

The age‐dependent association of Life's Simple 7 with transitions across cognitive states after age 60

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