Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults

Kuang, Maobin; Peng, Nan; Qiu, Jiajun; Zhong, Yanjia; Zou, Yang; Sheng, Guotai

doi:10.1186/s12944-022-01655-5

Cited by 10 publications

(4 citation statements)

References 47 publications

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“…According to a study, determining insulin resistance can be done with high accuracy using the lowdensity lipoprotein/high-density lipoprotein cholesterol ratio (LDL/HDL ratio) (Zhang, et al, 2015). Another study found that the risk of prediabetes is positively connected with an elevated LDL/HDL ratio (Kuang, et al, 2022). All of these results suggested that the LDL:HDL ratio might be a reliable indicator of blood glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

The HDL Level in Diabetic Foot Ulcer Patients With and Without Amputation at Dr. Seotomo General Academic Hospital Surabaya

Abuajwa¹,

Novida

Soebroto³

et al. 2023

MBIOMJ

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Highlights1. Diabetes mellitus is a category of metabolic disease characterized by uncontrolled hyperglycemia.2. This study revealed no statistically significant differences in total cholesterol, TG, LDL, HDL, or LDL/HDL ratio between amputated and non-amputated DFU patients. AbstractBackground: Diabetic foot ulcers (DFU) are microvascular and macrovascular consequences of diabetes and are associated with neuropathy, vascular disease, and immunosuppression. Increased blood glucose levels may result in the glycosylation of proteins in the nerve cells of the foot, leading to ischemia and cellular disturbances that can damage muscular, sensory, and autonomic neurons. Objective: To compare the lipid profiles of amputated and non-amputated DFU patients. Material and Method: This was a cross-sectional, analytic, retrospective research using total sample approach to analyze the medical records of all diabetes patients admitted to Dr. Soetomo General Academic Hospital between February 2018 and December 2020, with or without amputation. Result: The average age of DFU patients at Dr. Soetomo General Academic Hospital was 55.6 9.4 years, and the majority of patients were female (57%). Diabetic foot ulcers were most prevalent in the age group ≥50 years old (74%), amputated DFU patients had larger mean total cholesterol, TG, LDL, and HDL than non-amputated DFU patients, although the difference was not statistically significant. While the mean LDL/HDL ratio was greater in non-amputated DFU patients, the difference was statistically insignificant. The HDL level was low in 84% of amputated DFU patients, whereas in non-amputated DFU patients it was 81%. Conclusion: This research showed no significant variation in total cholesterol, TG, LDL, HDL, or the LDL/HDL ratio between amputated and non-amputated DFU patients. Most DFU patients with and without amputations had low HDL values.

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Section: Discussionmentioning

confidence: 99%

The HDL Level in Diabetic Foot Ulcer Patients With and Without Amputation at Dr. Seotomo General Academic Hospital Surabaya

Abuajwa¹,

Novida

Soebroto³

et al. 2023

MBIOMJ

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“…More importantly, testing of the parameters of cholesterol is essential to determine CVD risk in the population. A retrospective cohort study done among the Chinese population, reported that an increase in LDL:HDL ration indicated an increased risk of prediabetes, among women, family history of diabetes, younger population and non-obese people (7).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Cardiochek® Pa Point-of-care Testing (Poct) Analyser With a 3-in-1 Lipid Panel for Epidemiological Surveys

Lourdes,

Lin,

Saminathan

et al. 2023

Preprint

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Background Point-of-care testing (POCT) is commonly used in epidemiological surveys due to its various advantages, such as portability and immediate test results. The CardioChek® PA analyser 3-in-1 lipid panel measures total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. This study tested the reliability and diagnostic accuracy of the CardioChek® PA analyser using a 3-in-1 lipid panel. Methods A cross-sectional study design with quota sampling was used. A total of 203 respondents aged 18 years and above from a research centre in the Ministry of Health, Malaysia, were recruited. Venous blood was sent to the laboratory, while a POCT analyser was used for capillary blood measurements. Intraclass coefficient correlation (ICC) analysis was employed to determine the agreement between capillary and venous blood parameters. The diagnostic performance of the evaluated tests was evaluated using STATA version 12. Results The agreement between capillary and laboratory venous blood was moderate (0.64–0.67) for TC and HDL, good (0.75) for LDL and excellent (0.91) for TG). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were as follows: TC, 57.1%, 94.3%, 92.3% and 64.8%; TG, 76.0%, 100%, 100%, and 96.6%; HDL, 96.2%, 83.2%, 47.2% and 99.3%; and LDL, 81.0%, 100%, 100% and 68.3%, respectively. Conclusions The CardioChek® PA analyser showed acceptable diagnostic accuracy for screening high-risk individuals more often in places where laboratories are inaccessible. It could also be used in clinical settings where patients would benefit from swift treatment decisions.

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“…A case‒control study indicated that the LDL-C/HDL-C ratio was the main risk factor for ischemic strokes [ 20 ]. Kuang et al [ 21 ] found that the LDL-C/HDL-C ratio also has some value in prediabetes risk assessment, and the accuracy was better than that of LDL-C and HDL-C. However, their predictive value is often applied only to subgroups of the whole population, such as nonobese people with normal lipids and patients with nonvalvular atrial fibrillation.…”

Section: Introductionmentioning

confidence: 99%

Serum LDL-C/HDL-C ratio and the risk of carotid plaques: a longitudinal study

Wen

et al. 2022

BMC Cardiovasc Disord

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Background Dyslipidemia contributes to an increased risk of carotid atherosclerosis. However, the association between the ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) and carotid plaque formation has not been well documented. This study aims to assess the role of LDL-C/HDL-C in the risk of carotid plaque formation in a Chinese population. Methods We followed 2,191 participants who attended the annual routine health examination. Cox proportional hazards regression, restricted cubic spline (RCS), and subgroup analysis were applied to evaluate the association between the LDL-C/HDL-C ratio and carotid plaques. The hazard ratio (HR) and 95% confidence interval (CI) were used to estimate the strength of the association. Results Among 2,191 participants, 388 had incident carotid plaques detected, with a median follow-up time of 1.05 years. Compared with subjects younger than 45 years, those aged 45 to 59 years (HR: 2.00, 95% CI: 1.55–2.58) and over 60 years (HR: 3.36, 95% CI: 2.47–4.58) had an increased risk of carotid plaque formation. Males (HR: 1.26, 95% CI: 1.01–1.56), diabetes (HR: 1.46, 95% CI: 1.06–2.01) and a high LDL-C/HDL-C ratio (HR: 1.22, 95% CI: 1.07–1.38) were significantly linked with the occurrence of carotid plaques. After adjusting for potential confounding factors, we observed that a high LDL-C/HDL-C ratio promoted carotid plaque events (HR: 1.30, 95% CI: 1.12–1.50). The RCS analysis revealed a significant nonlinear association. The association was stronger among females (P-interaction < 0.05). Conclusion A high LDL-C/HDL-C ratio could accelerate the occurrence of carotid plaques. Older men with diabetes and dyslipidemia are the critical target population. Women may be more likely to benefit from lipid-lowering interventions and thus avoid carotid plaque formation.

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Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults

Cited by 10 publications

References 47 publications

The HDL Level in Diabetic Foot Ulcer Patients With and Without Amputation at Dr. Seotomo General Academic Hospital Surabaya

The HDL Level in Diabetic Foot Ulcer Patients With and Without Amputation at Dr. Seotomo General Academic Hospital Surabaya

Diagnostic Accuracy of Cardiochek® Pa Point-of-care Testing (Poct) Analyser With a 3-in-1 Lipid Panel for Epidemiological Surveys

Serum LDL-C/HDL-C ratio and the risk of carotid plaques: a longitudinal study

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