Association of Knee Injuries With Accelerated Knee Osteoarthritis Progression: Data From the Osteoarthritis Initiative

Driban, Jeffrey B.; Eaton, Charles B.; Lo, Grace H.; Ward, Robert James; McAlindon, Timothy E.

doi:10.1002/acr.22359

Cited by 93 publications

(121 citation statements)

References 29 publications

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“…However, approximately 22% of incident cases of KOA within the first 4 years of the Osteoarthritis Initiative (OAI) are an accelerated form of KOA (AKOA) [1,2]. Additionally, within the OAI we found an annual incidence rate of 6 AKOA cases per 1000 people.…”

Section: Introductionmentioning

confidence: 96%

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

Davis

Price

et al. 2017

Rheumatol Int

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We examined the association between previously reported modifiable risk factors for accelerated knee osteoarthritis (AKOA) at the Osteoarthritis Initiative's (OAI) baseline and 48-month visits among adults who develop AKOA between the 48- and 96-month visits . We conducted a case-control study using data from the OAI baseline to the 96 month visit. Participants had no radiographic knee osteoarthritis (KOA) in the index knee at OAI baseline and 48-month visits (Kellgren-Lawrence [KL] <2). We classified 2 groups: 1) AKOA: ≥1 knee developed advance-stage KOA (KL=3 or 4) between 48-and 96-month visits and 2) No KOA: no KOA and no change in radiographic severity bilaterally over 96 months. We used logistic regression models to evaluate the association between the outcome of AKOA (versus no KOA) and several modifiable risk factors collected at OAI baseline and 48-month visits (body mass index (BMI), systolic blood pressure, comorbidity score, and NSAID use). We also explored a new injury from baseline to 48-months and from 48- to 96-months. Adults with greater baseline and 48-month BMI were more likely to develop AKOA. Injury was only associated with AKOA onset when it occurred within 4 years of developing AKOA (prior 2 years: odds ratio=6.21; 95% confidence interval [CI]=3.40, 11.35; 2–4 years prior: odds ratio=4.42, 95% CI=2.06, 9.50)). BMI may consistently predispose an adult to AKOA, but certain injuries are likely a catalyst for AKOA.

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Section: Introductionmentioning

confidence: 96%

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

Davis

Price

et al. 2017

Rheumatol Int

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“…Despite knee injuries being associated with a greater risk for early-onset osteoarthritis (3) and accelerated KOA (4) very little is known about possible risk factors for injuries among adults over 45 years of age. We found that among knees with or without KOA that a history of knee injury and ipsilateral knee pain are associated with new knee injuries.…”

Section: Discussionmentioning

confidence: 99%

“…This last point is based on consistent evidence that knee injuries increase the risk of KOA (1–3). We previously demonstrated that among adults over 45 years of age that knee injuries are associated with incident KOA, particularly accelerated KOA (4). Based on the current analyses, we found that knee pain and a history of knee injury increases the risk of a knee injury among adults with and without radiographic osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

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Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative

Driban

Lo²,

Eaton³

et al. 2015

J Rheumatol

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Objectives We explored if knee pain or a history of knee injury was associated with a knee injury in the following 12 months. Methods We conducted longitudinal knee-based analyses among knees in the Osteoarthritis Initiative. We included both knees of all participants who had at least one follow-up visit with complete data. Our first sets of exposures were knee pain (chronic knee symptoms and severity) at baseline, 12-month, 24-month, and 36-month visits. Another exposure was a history of injury, which we defined as a self-reported injury at any time prior to baseline, 12-month, 24-month, or 36-month visits. The outcome was self-reported knee injury during the past year at 12-month, 24-month, 36-month, and 48-month visits. We evaluated the association between ipsilateral and contralateral knee pain or history of injury and a new knee injury within 12 months of the exposure using generalized linear mixed model for repeated binary outcomes. Results A knee with reported chronic knee symptoms or ipsilateral or contralateral history of an injury was more likely to experience a new knee injury in the following 12 months than a knee without chronic knee symptoms (odds ratio [OR]=1.84, 95% confidence interval [CI]=1.57, 2.16) or prior injury (prior ipsilateral knee injury OR=1.81, 95% CI=1.56, 2.09; prior contralateral knee injury OR=1.43, 95% CI=1.23, 1.66). Conclusion Knee pain and a history of injury are associated with new knee injuries. It may be beneficial for individuals with knee pain or a history of injury to participate in injury prevention programs.

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“…While knee OA is typically a slowly progressing disorder, it has recently been appreciated that 5-17 % of knee OA have a rapid progression of structural damage. The OAI study investigated whether a recent knee injury was associated with accelerated knee OA progression [63]. A knee injury during the total observation period was associated with accelerated knee OA progression (OR 3.1).…”

Section: Jkommentioning

confidence: 99%

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Ishijima

Kaneko

Hada

et al. 2016

Clinic Rev Bone Miner Metab

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Locomotive syndrome'' is defined as a condition associated with restriction in one's ability to walk or lead a normal life due to a dysfunction in one or more of the parts of the locomotion system, including the muscles, bones, joints, cartilage or intervertebral discs. This syndrome especially refers to individuals who have come to need nursing care services because of problems with the locomotive organs, or those who have conditions which may require them to need such services in the near future. Recent epidemiological studies revealed that the one-fourth of elderly individuals who require special assistance or nursing care have locomotive disorders in Japan. Osteoarthritis of the knee (knee OA) and hip (hip OA), and osteoporosis and spinal canal stenosis due to spondylosis are three major locomotive disorders that cause elderly individuals require special assistance or nursing care. In this review, we focus on the effects of knee and hip OA on the lives of elderly individuals and the recent advantages in clinical research on the pathophysiology and management of these diseases.

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Association of Knee Injuries With Accelerated Knee Osteoarthritis Progression: Data From the Osteoarthritis Initiative

Cited by 93 publications

References 29 publications

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

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