Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Ishijima, Muneaki; Kaneko, Haruka; Hada, S.; Kinoshita, M.; Sadatsuki, R.; Liu, Lizu; Shimura, Yukio; Arita, Hitoshi; Shiozawa, Jun; Yusup, A.; Futami, I.; Sakamoto, Yuko; Ishibashi, Masayoshi; Machida, Syuichi; Naito, Hisashi; Arikawa‐Hirasawa, Eri; Hamada, Chikuma; Saita, Yoshitomo; Takazawa, Yuji; Ikeda, Hiroshi; Okada, Yasunori

doi:10.1007/s12018-016-9212-6

Cited by 12 publications

(6 citation statements)

References 75 publications

(133 reference statements)

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“…MRI can be helpful in evaluating the integrity of the hyaline articular cartilage, subarticular bone abnormalities, subchondral cysts, meniscus changes, the cruciate ligaments and collateral ligaments, synovitis and intra-articular free bodies [59]. Commonly used laboratory tests (common blood count, biochemical screening) do not indicate to pathological changes in classical knee OA even in secondary synovitis and it serves a diagnostic criterion for differential diagnosis of the knee condition [60].…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

Knee osteoarthritis in obese and overweight patients: etiology and pathogenesis (literature review)

Sertakova¹,

Zvereva²,

Zotkin³

et al. 2020

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Introduction Based on WHO report, in 2008, the global prevalence of overweight reached over 1.4 billion people aged 20 years and over including more than 200 million men and 300 million women who suffered from obesity in 2012. More than 34 % of U.S. adults are overweight, and more than 27 % are obese. In European countries, the prevalence of obesity is 35-40 % among adult population. More than 30 percent of the Russia's working population is overweight, 25 percent of whom are obese. Material and methods Search engines used included MEDLINE, the primary component of Pubmed; the Electronic Library System, products from Elsevier and Springer publishing companies; open access articles of PubMed Central; BioMed Central; Free Medical Journals and open access publications using the keywords 'knee osteoarthritis', 'etiology and pathogenesis', 'knee osteoarthritis in obesity'. Results and discussion Osteoarthritis (OA) is multifactorial in origin and closely associated with genetic predisposition, sex and age, greater body mass index (BMI) and obesity. Family history, age, gender, previous injury or abnormal mechanical loading are common risk factors of knee OA. While the above risk factors can increase the chances of developing knee OA, they are not absolute. In clinical practice, in patients with new onset of knee pain 5.1 % of cases are due to previous knee injury and 24.6 % related to being overweight or obese. Such metabolic factors as obesity and dyslipidemia might be involved in the pathophysiology of knee OA. Increased free radical production associated with obesity results in degradation of articular cartilage and synovial involvement. The pathogenesis of knee OA attributable to obesity is predominantly related to unfavorable mechanical environment at the joint; chronic inflammation in adipose tissue and dyslipidemia; pro-inflammatory cytokines and adipokines secreted by the adipose tissue; cytokines secreted by infrapatellar fat pad. Conclusion Inflammatory mediators of adipose origin play a major role in the initiation and perpetuation of the obesity-induced OA. There is a significant multifactorial association between OA and obesity with central roles for LDL oxyforms, HDL synthesis and excessive activation of matrix metalloproteinases, adiponectin synthesis, the release of adipokines and excessive mechanical stress.

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Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

Knee osteoarthritis in obese and overweight patients: etiology and pathogenesis (literature review)

Sertakova¹,

Zvereva²,

Zotkin³

et al. 2020

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“…However, medial meniscus disposition occurs not only medially (MME) but also anteriorly, and the anterior deviation of the meniscus is called as anterior meniscus extrusion (AME) [ 9 ]. In case of changes in position and/or morphology of the meniscus, mechanical force to the articular cartilage is inadequately dispersed and the overall biomechanics of the knee joint are altered, resulting in increased risk for cartilage loss and incidence and progression of knee OA [ 3 , 8 , [10] , [11] , [12] , [13] , [14] , [15] , [16] ]. Actually, MME is known to be an important risk factor for the incidence and progression of knee OA [ 14 , [17] , [18] , [19] ].…”

Section: Introductionmentioning

confidence: 99%

Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis – The Bunkyo Health Study

Adili¹,

Kaneko²,

Aoki³

et al. 2023

Osteoarthritis and Cartilage Open

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“…Nearly 30% of individuals older than 45 years old and over 80% of women older than 80 years old are reported to have radiographic knee OA in the United States and Japan, respectively 3,4 . With increased numbers of elderly people, patients with knee OA are increasing worldwide 5 . Elucidation of the progression mechanism and development of treatment methods for knee OA will be important to extend healthy life expectancy 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study

Negishi

Kaneko

Aoki

et al. 2022

Preprint

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We reported that full-length width of medial tibial osteophyte composed of cartilage and bone parts is directly correlated with medial meniscus extrusion (MME) in early-stage knee osteoarthritis (OA). However, no data are available for MME prevalence and its relationship to osteophyte in elderlies. 1,191 elderlies (females 57%; 72.9 years old on average) in the Bunkyo Health Study underwent standing plain radiograph and proton density-weighted MRI on knee joints. MRI-detected OA changes were evaluated according to the Whole Organ Magnetic Resonance Imaging Score. A new method to assess cartilage and bone parts of osteophyte was developed by pseudo-coloring images of proton density-weighted fat-suppressed MRI. Most of the subjects showed the Kellgren-Lawrence grade 1 or 2 of radiographic medial knee OA (88.1%), MME (98.7%, 3.90 ± 2.01 mm) and medial tibial osteophyte (99.3%, 3.27 ± 1.50 mm). Among the OA changes, MME was most closely associated with full-length width of medial tibial osteophyte (β = 1.114; 95%CI, 1.069–1.159; p < 0.001) and consistent with osteophyte width (intraclass correlation coefficient, 0.804; 95%CI, 0.783–0.823). Our data reveal that MME and medial tibial osteophyte are invariably observed in elderlies, and demonstrate that degree of MME is consistent with the full-length width of medial tibial osteophyte, suggesting that osteophyte might be implicated for MME.

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Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Cited by 12 publications

References 75 publications

Knee osteoarthritis in obese and overweight patients: etiology and pathogenesis (literature review)

Knee osteoarthritis in obese and overweight patients: etiology and pathogenesis (literature review)

Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis – The Bunkyo Health Study

Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study

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