Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections

Abstract

KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

“…Since then, eight case-control studies have been undertaken to identify the association between KIR polymorphisms and RA [14,20,21,[31][32][33][34][35], but the results were controversial. Based on cumulated evidence, we performed a meta-analysis with data from nine studies with a total of 1428 RA cases and 2115 healthy controls to reassess the associations.…”

“…1. Among the nine articles, four [20,22,32,33] were Caucasians, three [21,31,35] were from East Asian countries, one [34] was from India and one [14] was from Latin America. Because of the inadequate sample populations available for the Indian and Latin American group, we performed ethnicity-specific meta-analysis for Caucasian and East Asian populations.…”

“…HWE test was performed on genotype distribution of the control groups, only one [34] of them showed p > 0.05 in HWE, other articles could not be tested because of the lack of raw data. Six [14,20,31,32,34,35] of the nine studies were of high quality (NOS score P 7) and the other three scored six and are shown in Table 1.…”

“…The associations between KIR genes and autoimmune diseases have been widely reported, such as rheumatoid arthritis (RA) [20][21][22], ankylosing spondylitis (AS) [23,24], systemic lupus erythematosus (SLE) [25], psoriasis [26,27], pemphigus foliaceus [28], scleroderma [25], multiple sclerosis [29], diabetes [30], etc. Plentiful case-control studies have investigated the association between these KIR gene polymorphisms and RA risk, but findings are not always consistent [14,[20][21][22][31][32][33][34][35]. In addition, until now, nobody performed a meta-analysis to estimate the association of KIR polymorphisms with RA risk.…”

Age-related changes in natural killer cell receptors from childhood through old age

“…Ligand specificities of activating KIR2DS3 remain mysterious. Although the ligand of KIR2DL5 is still undetermined, KIR2DL5 is considered one of the functional inhibitory receptors [49,50]. So far, the expression of these two receptors was not examined in older individuals.…”