Association of KCNQ1rs2237892C$⟶$T Gene with Type 2 Diabetes Mellitus: A Meta-Analysis

Abstract

Background. Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in adults, causing high morbidity and mortality worldwide. In recent years, the prevalence of T2DM has been increasing significantly, and genome-wide association studies (GWAS) have shown that KCNQ1 significantly increases the risk of T2DM. Objective. To find large-scale evidence on whether the KCNQ1rs2237892C⟶T gene polymorphism is associated with T2DM susceptibility. Methods. A comprehensive review of the Chinese and English literature on the association of T2DM with KCNQ1rs2237892 is published by PubMed and Baidu Academic. The included literature was part or all of the studied loci which were evaluated for association with T2DM. Forest plots were made of the included literature to analyze the association of KCNQ1 with polymorphisms of the studied loci, and funnel plots and Egger’s test were used to evaluate the publication bias of the selected included literature. Results. Ten case-control studies including a total of 7027 cases and 8208 controls met our inclusion criteria. Allele (C allele frequency distribution) (OR: 1.19; 95% CI: 0.87,1.62; P < 0.00001 ), recessive (OR: 0.73; 95% CI: 0.45,1.18; P < 0.00001 ) genetic model under the full population was observed between KCNQ1rs2237892C⟶T gene polymorphism and T2DM without a significant relationship. In a stratified analysis by race, a meaningful association was found in non-Asian populations under the allelic genetic model, but no association was found in Asian populations. Conclusion. This meta-analysis showed no significant association between the rs2237892 polymorphism of the KCNQ1 gene and the risk of T2DM.

KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

“…Previous studies have shown that the KCNQ1 , miR-21 , and Arg972 may be risk genes for T2DM[ 25 , 26 ]. KCNQ1 gene has now been shown to be located on chromosome 11p15.5, which is approximately 400 kb in length and consists of 17 exons ranging from 47 to 1122 bp in length[ 27 ]. KCNQ1 is associated with voltage-gated K + channels, and mutations in the KCNQ1 gene lead to dysfunction of K + channels, which would cause diseases such as QT syndrome and familial atrial fibrillation.…”

“…KCNQ1 is associated with voltage-gated K + channels, and mutations in the KCNQ1 gene lead to dysfunction of K + channels, which would cause diseases such as QT syndrome and familial atrial fibrillation. KCNQ1 is expressed in many tissues[ 27 , 28 ], and the more studied about the KCNQ1 gene is expressed in cardiac and pancreatic tissues[ 29 ]. Current studies suggest that the main mechanisms of T2DM development are insulin resistance and islet β-cell dysfunction[ 2 , 23 ].…”