Novel single nucleotide polymorphisms in gestational diabetes mellitus

Wang, Yuqi; Li, Ling; Li, Ping

doi:10.1016/j.cca.2022.11.010

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…Differences in the perinatal outcomes of diet therapy between early and late GDM might be affected by these criteria. Asians, including Japanese, exhibit impaired insulin secretion, which is an important mechanism for GDM development [ 18 , 19 , 20 , 21 , 22 ]. There are many underweight (pre-pregnancy BMI < 18.5 kg/m 2 ) cases with GDM in Japan [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Perinatal Outcomes of Diet Therapy in Gestational Diabetes Mellitus Diagnosed before 24 Gestational Weeks

Kasuga,

Takahashi,

Kajikawa

et al. 2024

Nutrients

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To evaluate perinatal outcomes and risk factors for large for gestational age (LGA; birth weight over 90 percentile) in gestational diabetes diagnosed before 24 gestational weeks and treated with diet therapy alone until delivery (Diet Early gestational diabetes mellitus (Diet Early GDM)), we assessed the maternal characteristics and perinatal outcomes of patients with early GDM (n = 309) and normal glucose tolerance (NGT; n = 309) at Keio University Hospital. The gestational weight gain (GWG) expected at 40 weeks was significantly lower in the Diet Early GDM group than in the NGT group. The Diet Early GDM group exhibited a significantly lower incidence of low birth weight (<2500 g) and higher Apgar score at 5 min than the NGT group. Multiple logistic regression analysis revealed that the pre-pregnancy body mass index and GWG expected at 40 weeks were significantly associated with LGA for Diet Early GDM. No differences were observed in random plasma glucose levels in the first trimester, 75 g oral glucose tolerance test values, and initial increase or subsequent decrease between the two groups. Dietary early GDM did not exhibit a worse prognosis than NGT. To prevent LGA, it might be important to control maternal body weight not only during pregnancy but also before conception.

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Section: Discussionmentioning

confidence: 99%

Perinatal Outcomes of Diet Therapy in Gestational Diabetes Mellitus Diagnosed before 24 Gestational Weeks

Kasuga,

Takahashi,

Kajikawa

et al. 2024

Nutrients

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“…Global SNP studies of ADIPOQ in GDM with various variants, such as rs2241766, rs1501299, rs266729, rs12495941, rs182052, rs140531754, and rs17300539, have revealed all forms of association [24,30,[52][53][54][55][56][57][58][59][60][61][62][63][64][65][66]. Different SNPs were studied in the ADIPOQ gene in women with GDM in various ethnicities, and in a recent study in Thai women with GDM, a couple of SNPs, rs182052 and rs140531754, were studied and confirmed as negative associations [65].…”

Section: Discussionmentioning

confidence: 99%

Dissecting the Molecular Role of ADIPOQ SNPs in Saudi Women Diagnosed with Gestational Diabetes Mellitus

et al. 2023

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The traditional definition of gestational diabetes mellitus (GDM) is the leading cause of carbohydrate intolerance in hyperglycemia of varying severity, with onset or initial detection during pregnancy. Previous studies have reported a relationship among obesity, adiponectin (ADIPOQ), and diabetes in Saudi Arabia. ADIPOQ is an adipokine that is produced and secreted by adipose tissue involved in the regulation of carbohydrate and fatty acid metabolism. This study investigated the molecular association between rs1501299, rs17846866, and rs2241766 single-nucleotide polymorphisms (SNPs) in ADIPOQ and GDM in Saudi Arabia. Patients with GDM and control patients were selected, and serum and molecular analyses were performed. Statistical analyses were performed on clinical data, Hardy Weinberg Equilibrium, genotype and allele frequencies, multiple logistic regression, ANOVA, haplotype, linkage disequilibrium, as well as MDR and GMDR analyses. The clinical data showed significant differences in various parameters between the GDM and non-GDM groups (p < 0.05). In GDM women with alleles, genotypes, and different genetic models, the rs1501299 and rs2241766 SNPs showed a strong association (p < 0.05). Multiple logistic regression analysis revealed a negative correlation (p > 0.05). This study concluded that rs1501299 and rs2241766 SNPs were strongly associated with GDM in women in Saudi Arabia.

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“…Many efforts are also focused on elucidating the basis of disease-associated genes by detecting the important associated single-base mutation. The association between gene-related diseases and SNPs can help us better understand the pathogenesis of diseases and attract the interest of contemporary scientists (Xiang et al, 2021;Yi et al, 2022;Wang et al, 2023). Therefore, it is imperative to develop a detection platform for SNPs, especially for genetic diseases.…”

Section: Introductionmentioning

confidence: 99%

A FEN 1-driven DNA walker-like reaction coupling with magnetic bead-based separation for specific SNP detection

Xu,

Chen,

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Single-nucleotide polymorphism (SNP) plays a key role in the carcinogenesis of the human genome, and understanding the intrinsic relationship between individual genetic variations and carcinogenesis lies heavily in the establishment of a precise and sensitive SNP detection platform. Given this, a powerful and reliable SNP detection platform is proposed by a flap endonuclease 1 (FEN 1)-driven DNA walker-like reaction coupling with a magnetic bead (MB)-based separation. A carboxyfluorescein (FAM)-labeled downstream probe (DP) was decorated on a streptavidin magnetic bead (SMB). The target DNA, as a walker strand, was captured by hybridization with DP and an upstream probe (UP) to form a three-base overlapping structure and execute the walking function on the surface of SMB. FEN 1 was employed to specifically recognize the three-base overlapping structure and cut the 5′flap at the SNP site to report the walking event and signal amplification. Considering the fact that the fluorescence was labeled on the cleavage and uncleavage sequences of DP and the target DNA-triggered walking event was undistinguishable from the mixtures, magnetic separation came in handy for cleavage probe (CP) isolation and discrimination of the amplified signal from the background signal. In comparison with the conventional DNA walker reaction, this strategy was coupling with SMB-based separation, thus promising a powerful and reliable method for SNP detection and signal amplification.

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Novel single nucleotide polymorphisms in gestational diabetes mellitus

Cited by 6 publications

References 56 publications

Perinatal Outcomes of Diet Therapy in Gestational Diabetes Mellitus Diagnosed before 24 Gestational Weeks

Perinatal Outcomes of Diet Therapy in Gestational Diabetes Mellitus Diagnosed before 24 Gestational Weeks

Dissecting the Molecular Role of ADIPOQ SNPs in Saudi Women Diagnosed with Gestational Diabetes Mellitus

A FEN 1-driven DNA walker-like reaction coupling with magnetic bead-based separation for specific SNP detection

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