Association of Interleukin-8 with Hot Flashes in Premenopausal, Perimenopausal, and Postmenopausal Women and Bilateral Oophorectomized Women

Uemura, Hirokazu; Tomita, Junko; Miyatani, Yuka; Yamada, Masayo; Kuwahara, Akira; Matsuzaki, Takashi; Murakami, Masahiko; Tsuchiya, Naho; Yuzurihara, Mitsutoshi; Takeda, Susumu; Irahara, Minoru

doi:10.1210/jc.2006-1100

Cited by 55 publications

(43 citation statements)

References 17 publications

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“…In the present study, we confirmed that serum IL-8 concentration in women with hot flashes was higher than that in women without hot flashes as shown in our previous study (21). In addition, we showed that oral ET increased IL-8 level, but that transdermal ET decreased IL-8 level.…”

Section: Discussionsupporting

confidence: 92%

Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy

Saijo¹,

Uemura²,

Matsuzaki³

et al. 2009

European Journal of Endocrinology

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Objective: The aim of the present study was to determine the different effects of oral estrogen therapy (ET) and transdermal ET on changes in circulating levels of cytokines and chemokines in relationship to changes in markers of inflammation in postmenopausal women with hysterectomy. Methods: Fifty-five postmenopausal women with hysterectomy were randomly assigned in open, parallel-group fashion to an oral ET group and a transdermal ET group. Serum levels of cytokines and chemokines were simultaneously measured using a multiplexed human cytokine assay. Serum concentrations of high-sensitive C-reactive protein, soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, and E-selectin were measured as vascular inflammation markers. Results: Both oral ET and transdermal ET significantly decreased serum interleukin (IL)-7 concentrations at 12 months (PZ0.020 and PZ0.015 respectively). Transdermal ET decreased serum concentrations of IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1b (PZ0.05, PZ0.019, and PZ0.029), but oral ET increased IL-8 level (PZ0.025). There were significant differences in percentage changes in IL-8 and MIP-1b between the oral and transdermal ET groups. Oral ET significantly decreased E-selectin level after 12 months. Conclusion: Transdermal ET reduces circulating levels of IL-8, MCP-1, and MIP-1b, while both oral ET and transdermal ET reduce circulating level of IL-7.

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Section: Discussionsupporting

confidence: 92%

Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy

Saijo¹,

Uemura²,

Matsuzaki³

et al. 2009

European Journal of Endocrinology

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“…Studies taking into account large populations and people with an average age of over 60 years have suggested an inverse association between physical activity and inflammatory biomarkers [4,5]. The effects of physical exercise on systemic inflammation occur through weight loss and adipose tissue loss [6], and it is likely that the difference between groups is due to the higher body mass index and body fat percentage in the sedentary group.…”

Section: Resultsmentioning

confidence: 99%

Comparing plasma levels of C-reactive protein, interleukin-10 and -15 in physically active and sedentary postmenopausal women Kane Ayntrlv

Sarhadi

Farsani

Hassanzadeh

2017

Salmand

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Objectives Lower levels of inflammatory cytokines and higher levels of anti-inflammatory cytokines are associated with increased life expectancy. However, the effects of regular physical activity on these cytokines in postmenopausal women have not been investigated very well. Methods & Materials Fifteen active and 15 inactive postmenopausal women (aged between 50-60 years) were recruited randomly. The exclusion criteria included chronic diseases, smoking, and surgeries in the past year. Also, more than a year should have passed since all subjects experienced natural menopause. Active postmenopausal women should have regular physical activity included walking, jogging, and resistance exercises and they should have performed these exercises three times a week within the past 6-12 months. After 12 hours of fasting, blood samples were taken in rest. Blood sample was centrifuged at 4000 rpm for 5 minutes, and the serum was frozen and stored at -80°C until biochemical analyses were performed. Independent t test was used to compare quantitative variables, and α level for statistical significance was set at P≤0.05. Results Regular physical activity brings about a significant decrease in C-reactive protein, significant increase in IL-15 and non-significant increase in IL-10 in active postmenopausal women in comparison to inactive postmenopausal women. Conclusion Regular physical activity may result in lower incidence of chronic diseases in postmenopausal women via decreased inflammatory cytokines and increased anti-inflammatory cytokines and could, therefore, play a role in higher life expectancy. . Cytokines of IL-10 and IL-15 may contribute in reducing the risk of disease and increasing longevity among the elderly. Given that little or contradictory research has been carried on the effect of regular exercise on cytokines, the present study aimed to study the resting cytokine levels of CRP, IL-10 and IL-15 in physically active postmenopausal women and compare it with sedentary postmenopausal women. A B S T R A C T Methods & MaterialsThis study was approved by the Ethics Committee of Qazvin Islamic Azad University. In order to select physically active postmenopausal women, the sports clubs and gyms in Karaj were visited, and notifications and questionnaires were distributed for the purpose of cooperation in research. About 89 questionnaires were completed; of them, 22 subjects were in the age range of 50-60 years and were thus excluded from the study. Some notifications were distributed in the gathering places of old women and public places in order to select sedentary postmenopausal women. Finally, 52 people volunteered out of which 17 were eligible. The exclusion criteria were having chronic diseases, smoking, and surgeries in the past year. Also, more than a year should have passed since all subjects experienced natural menopause. Active postmenopausal women should have regular physical activity, including walking, jogging, and resistance exercises and they should also have performed these exercises three times a wee...

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“…Increased level of macrophage chemoattractant protein 1 was also associated with higher odds of night sweats [37]. Several smaller studies support the association between hot flushes and impaired adipokine secretion [38][39][40].…”

Section: Vasomotor Symptoms and Obesitymentioning

confidence: 93%

Vasomotor symptoms and metabolic syndrome

Tuomikoski

Savolainen-Peltonen

2017

Maturitas

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a b s t r a c tA vast majority of menopausal women suffer from vasomotor symptoms, such as hot flushes and night sweats, the mean duration of which may be up to 7-10 years. In addition to a decreased quality of life, vasomotor symptoms may have an impact on overall health. Vasomotor symptoms are associated with overactivity of the sympathetic nervous system, and sympathetic overdrive in turn is associated with metabolic syndrome, which is a known risk factor for cardiovascular disease. Menopausal hot flushes have a complex relationship to different features of the metabolic syndrome and not all data point towards an association between vasomotor symptoms and metabolic syndrome. Thus, it is still unclear whether vasomotor symptoms are an independent risk factor for metabolic syndrome. Research in this area is constantly evolving and we present here the most recent data on the possible association between menopausal vasomotor symptoms and the metabolic syndrome.

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Association of Interleukin-8 with Hot Flashes in Premenopausal, Perimenopausal, and Postmenopausal Women and Bilateral Oophorectomized Women

Abstract: Serum IL-8 concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes were significantly higher than those in women without hot flashes. IL-8 may be associated with peripheral vasodilation in women with hot flashes.

Cited by 55 publications

References 17 publications

Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy

Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy

Comparing plasma levels of C-reactive protein, interleukin-10 and -15 in physically active and sedentary postmenopausal women Kane Ayntrlv

Vasomotor symptoms and metabolic syndrome

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