Association of Interleukin-6 With the Progression of Carotid Atherosclerosis

Okazaki, Shuhei; Sakaguchi, Manabu; Miwa, Kaori; Furukado, Shigetaka; Yamagami, Hiroshi; Yagita, Yoshiki; Mochizuki, Hideki; Kitagawa, Kazuo

doi:10.1161/strokeaha.114.005991

Cited by 54 publications

(42 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It can stimulate hepatic synthesis of acute-phase proteins, activate endothelial cells, promote lymphocyte proliferation, neutrophil migration and macrophage differentiation [47, 48]. In the general population, higher plasma IL-6 levels have been associated with greater carotid IMT [49], atherosclerosis progression [50], coronary heart disease [51] and CV deaths [52]. Similarly, in HIV-infected individuals on ART, higher plasma IL-6 levels have been associated with CVD [17], CV deaths [16] and mortality [25].…”

Section: Discussionmentioning

confidence: 99%

Plasma IL-6 levels are independently associated with atherosclerosis and mortality in HIV-infected individuals on suppressive antiretroviral therapy

Hsu

Hur

et al. 2016

Aids

View full text Add to dashboard Cite

Objective To determine the associations of markers of immune activation with atherosclerosis and mortality, in participants with treated and suppressed HIV infection. Design Observational study of 149 HIV-infected participants with virologic suppression on antiretroviral therapy. Methods Cryopreserved mononuclear cells and plasma were used to evaluate markers of T cell and monocyte activation, inflammation and coagulopathy. Carotid artery intima-media thickness (CIMT) was measured by high-resolution ultrasound at the common, bifurcation and internal carotid regions. Associations of immunologic markers with CIMT and all-cause mortality were assessed using multivariable linear regression and Cox proportional hazards regression. Results The majority of participants were male (93%) and white (67%), median age of 48.5 years and median CD4+ T cell count of 522 cells/μL. The median baseline IMT was 1.0 mm. Over a median of 8.3 years of follow-up, 12 deaths occurred. In multivariate analysis, adjusted for traditional cardiovascular risk factors, higher monocyte CCR5 expression (5.4%, 95%CI [2.4–8.4], p=0.001) was associated with greater common carotid IMT. Higher plasma IL-6 was associated with greater bifurcation (8.0%, 95%CI [2.3–13.7], p=0.007) and overall mean IMT (5.2%, 95%CI [0.7–9.7], p=0.026). Finally, higher plasma IL-6 (HR 1.9, 95%CI [1.0–3.7], p=0.030), internal carotid (HR 4.1, 95%CI [1.2–13.7], p=0.022) and mean IMT (HR 5.2, 95%CI [1.2–22.1], p=0.026) were individually associated with all-cause mortality. Conclusions Higher monocyte CCR5 expression and plasma IL-6 were associated with atherosclerosis, independent of traditional cardiovascular risk factors. IL-6 and CIMT were individually associated with all-cause mortality. The impact of therapies targeting immune activation in CVD in treated HIV infection merits additional investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma IL-6 levels are independently associated with atherosclerosis and mortality in HIV-infected individuals on suppressive antiretroviral therapy

Hsu

Hur

et al. 2016

Aids

View full text Add to dashboard Cite

show abstract

“…In fact, inflammation is now considered a key event in vascular dysfunction and the development of CVDs (Okazaki et al . ; Libby & Hansson, ; Rein et al . ).…”

Section: Introductionmentioning

confidence: 99%

Diabetes and ageing‐induced vascular inflammation

Assar

Angulo

Rodríguez‐Mañas

2015

The Journal of Physiology

100

View full text Add to dashboard Cite

Diabetes and the ageing process independently increase the risk for cardiovascular disease (CVD). Since incidence of diabetes increases as people get older, the diabetic older adults represent the largest population of diabetic subjects. This group of patients would potentially be threatened by the development of CVD related to both ageing and diabetes. The relationship between CVD, ageing and diabetes is explained by the negative impact of these conditions on vascular function. Functional and clinical evidence supports the role of vascular inflammation induced by the ageing process and by diabetes in vascular impairment and CVD. Inflammatory mechanisms in both aged and diabetic vasculature include pro‐inflammatory cytokines, vascular hyperactivation of nuclear factor‐кB, increased expression of cyclooxygenase and inducible nitric oxide synthase, imbalanced expression of pro/anti‐inflammatory microRNAs, and dysfunctional stress‐response systems (sirtuins, Nrf2). In contrast, there are scarce data regarding the interaction of these mechanisms when ageing and diabetes co‐exist and its impact on vascular function. Older diabetic animals and humans display higher vascular impairment and CVD risk than those either aged or diabetic, suggesting that chronic low‐grade inflammation in ageing creates a vascular environment favouring the mechanisms of vascular damage driven by diabetes. Further research is needed to determine the specific inflammatory mechanisms responsible for exacerbated vascular impairment in older diabetic subjects in order to design effective therapeutic interventions to minimize the impact of vascular inflammation. This would help to prevent or delay CVD and the specific clinical manifestations (cognitive decline, frailty and disability) promoted by diabetes‐induced vascular impairment in the elderly.

show abstract

“…However, recent evidence has shown the progression of the disease to be more related to inflammation within the blood vessel wall [3]. Accordingly, individuals with elevated levels of systemic inflammation have been shown to have an increased risk for sudden cardiac events and mortality [4–6]. Previous research suggests that even a single high-fat meal (HFM) may induce postprandial inflammation [7, 8] and endothelial dysfunction [9], due to the prolonged elevation of TRG in the blood stream known as postprandial lipemia (PPL) [10].…”

Section: Introductionmentioning

confidence: 99%

Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise

et al. 2016

View full text Add to dashboard Cite

Postprandial lipemia is an independent risk factor for development of cardiovascular disease. Postprandial inflammation following the prolonged elevation of triglycerides occurring subsequent to ingestion of high-fat meals, provides a likely explanation for increased disease risk. Substantial evidence has shown that acute exercise is an effective modality for attenuation of postprandial lipemia following a high-fat meal. However, much of the evidence pertaining to exercise intensity, duration, and overall energy expenditure for reducing postprandial lipemia is inconsistent. The effects of these different exercise variables on postprandial inflammation is largely unknown. Long-term, frequent exercise, however, appears to effectively reduce systemic inflammation, especially in at-risk or diseased individuals. With regard to an acute postprandial response, without a recent bout of exercise, high levels of chronic exercise do not appear to reduce postprandial lipemia. This review summarizes the current literature on postprandial and inflammatory responses to high-fat meals, and the roles that both acute and chronic exercise play. This review may be valuable for health professionals who wish to provide evidence-based, pragmatic advice for reducing postprandial lipemia and cardiovascular disease risk for their patients. A brief review of proposed mechanisms explaining how high-fat meals may result in pro-inflammatory and pro-atherosclerotic environments is also included.

show abstract

Association of Interleukin-6 With the Progression of Carotid Atherosclerosis

Cited by 54 publications

References 35 publications

Plasma IL-6 levels are independently associated with atherosclerosis and mortality in HIV-infected individuals on suppressive antiretroviral therapy

Plasma IL-6 levels are independently associated with atherosclerosis and mortality in HIV-infected individuals on suppressive antiretroviral therapy

Diabetes and ageing‐induced vascular inflammation

Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise

Contact Info

Product

Resources

About