Association of interleukin‐13 C‐1112T and G+2044A polymorphisms with asthma: A meta‐analysis

Yang, Haijun; Dong, Haiyan; Dai, Yufei; Zheng, Yuxin

doi:10.1111/j.1440-1843.2011.02021.x

Cited by 14 publications

(13 citation statements)

References 63 publications

(132 reference statements)

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“…8,9 The IL-13 gene is found on chromosome 5q31-33 and has been significantly associated with allergic asthma. 10 The T allele of the IL13 C1923T and IL13 C1112T have both shown to be significantly associated with increased risk of asthma, 11,12 and rs1295686 is involved in the dysregulation of total IgE.…”

Section: Introductionmentioning

confidence: 99%

Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius

Ramphul

Bao

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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Section: Introductionmentioning

confidence: 99%

Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius

Ramphul

Bao

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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“…A recent meta-analysis performed by Yang et al [41] found +2044A/G polymorphism was associated asthma risk in Asians but not in Caucasians. Another meta-analysis conducted by Cui et al [42] showed this polymorphism was more pronounced among Caucasians but not among Asians.…”

Section: Discussionmentioning

confidence: 95%

“…There are several potential explanations for the different results. First, different inclusion and exclusion criteria were used in these two meta-analyses [41], [42]. For example, Cui et al [42] only included English papers.…”

Section: Discussionmentioning

confidence: 99%

“…However, the results from these studies were inconsistent. Although two meta-analyses on these polymorphisms have be published [41], [42], some inconsistent results still existed. For example, Yang et al [41] reported that IL-13 +2044A allele was associated with an increased risk of asthma among Asians but not among Caucasians.…”

Section: Introductionmentioning

confidence: 99%

“…Although two meta-analyses on these polymorphisms have be published [41], [42], some inconsistent results still existed. For example, Yang et al [41] reported that IL-13 +2044A allele was associated with an increased risk of asthma among Asians but not among Caucasians. However, Cui et al [42] found that IL-13 +2044A/G polymorphism was associated Caucasians but not Asians.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis

et al. 2013

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BackgroundAssociations between interleukin-13 (IL-13) polymorphisms and asthma risk remained controversial and ambiguous. Therefore, we performed a meta-analysis to assess the associations between IL-13 polymorphisms and asthma susceptibility.MethodsPubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model.ResultsThirty-four studies were included in this meta-analysis. The results indicated that IL13 -1112C/T polymorphism was significantly associated with asthma risk (OR = 1.20, 95% CI 1.08–1.34, P = 0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR = 1.30, 95% CI 1.09–1.55, P = 0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR = 1.25, 95% CI 1.07–1.45, P = 0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR = 1.18, 95% CI 1.08–1.28, P = 0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR = 1.19, 95% CI 1.04–1.36, P = 0.01) and Caucasians (OR = 1.22, 95% CI 1.06–1.40, P = 0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR = 1.12, 95% CI 1.00–1.26, P = 0.05).ConclusionsThis meta-analysis suggested that the IL13 -1112C/T and +2044A/G polymorphisms were risk factors for asthma.

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Association between the interleukin-4, interleukin-13 polymorphisms and asthma: a meta-analysis

et al. 2012

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A numbers studies had been reported that the polymorphisms in the Interleukin 4 (IL-4) and Interleukin 13 (IL-13) genes were associated with susceptibility to asthma. However, the results were inconsistent and inconclusive. We carried out a meta-analysis of case-control genetic association studies to assess whether the combined data showed this association by using a genetic model-free approach. Thirty studies (total 12,781 asthma and 11,500 controls) for the IL-4 C-33T and C-589T, IL-13 C-1112T and G+2044A with asthma were included in the meta-analysis. The results indicated that there were an association between the IL-4 C-33T (P = 0.006) and C-589T (P = 0.04), IL-13 C-1112T (P = 0.002) and G+2044A (P = 0.04) and susceptibility to asthma. And the definition of asthma subgroup meta-analysis demonstrates that the IL-4 C-33T is not associated with nonatopic or atopic, and IL-4 C-589T and IL-13 C-1112T polymorphisms are not associated with atopic. In the ethnicity subgroup meta-analysis, the IL-4 -589T (P = 0.003) and the IL-13 -1112T (P < 0.00001) alleles are associated with asthma among Caucasian, but not on the IL-13 +2044A allele. In conclusion, IL-4 C-33T and C-589T, IL-13 C-1112T and G+2044A could be proposed as asthma susceptible SNPs. Further investigation in larger studies and meta-analysis is required.

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Association of interleukin‐13 C‐1112T and G+2044A polymorphisms with asthma: A meta‐analysis

Cited by 14 publications

References 63 publications

Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius

Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius

Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis

Association between the interleukin-4, interleukin-13 polymorphisms and asthma: a meta-analysis

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