Association of Interleukin-10 -1082G &gt; A Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Based on 21 Studies

Veisian, Mehrnaz; Tabatabaei, Razieh Sadat; Javaheri, Atiyeh; Abbasi, Hajar; Salimi, Erfaneh; Hadadan, Amaneh; Zanbagh, Leila; Dastgheib, Seyed Alireza; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1683919

Cited by 10 publications

(8 citation statements)

References 40 publications

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“… 30 Another systematic review reported that IL10 −1082 G>A polymorphism significantly increased the risk of preeclampsia in Asian women, but not in White population. 31 Besides impaired placentation, immunological factors, endothelial function, and inflammation have all been identified as contributors to the pathophysiology of preeclampsia. 32 Although circulating PlGF and MAP mainly reflect placentation and maternal endothelial function, respectively, racial disparities on pathophysiology might influence the effectiveness of the predictors.…”

Section: Discussionmentioning

confidence: 99%

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

et al. 2021

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ObjectivePrevious studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.DesignA prospective cohort study.SettingKK Women’s and Children’s Hospital, Singapore.ParticipantsA total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomesPreeclampsia was the main pregnancy outcome.ResultsA total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.ConclusionMAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.

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Section: Discussionmentioning

confidence: 99%

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

et al. 2021

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“…Moreover, after subgroup an analysis, heterogeneity was obviously decreased in Asians; however, the corresponding pooled ORs were not materially altered after deleting these studies, indicating that our results were statistically robust. Publication bias is another key factor that might affect the quality of a meta-analysis (Niktabar et al, 2019;Veisian et al, 2019). Both Begg's and Egger's test were used to assess publication bias in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Karimi-Zarchi¹,

Abbasi²,

Javaheri³

et al. 2020

Asian Pac J Cancer Prev

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Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al., 2010; Mousavi et al., 2008). According to GLOBOCAN, cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide in 2012 (Parkin et al., 2005). Although, it has been widely accepted for several decades that Human papillomavirus (HPV) is the main risk factor for development of cervical cancer (Behtash et al., 2009; Farbod et al., 2019; Ghaemmaghami et al., 2008), HPV infections have developed to persistent infection in only a very few cases and it is sufficient to induce cervical cancer in an even smaller proportion

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“…IL-10e1082 guanine>adenine polymorphism stratified by ethnicity found a markedly increased risk of developing preeclampsia in Asian and mixed-race populations but not in White populations. 82 Although some racial and ethnic trends in gene expression have been suggested in the aforementioned studies, more investigation is needed to elucidate the degree to which these genotypes can or cannot affect the risk of preeclampsia in the presence of other clinical risk factors.…”

Section: Expert Reviewmentioning

confidence: 99%

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

Johnson

Louis

2022

American Journal of Obstetrics and Gynecology

108

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Association of Interleukin-10 -1082G > A Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Based on 21 Studies

Cited by 10 publications

References 40 publications

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

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