Association of Interleukin‐1 Polymorphisms With Periodontal Disease

López, Néstor J.; Jara, Lilian; Valenzuela, Carlos Y

doi:10.1902/jop.2005.76.2.234

Cited by 81 publications

(76 citation statements)

References 43 publications

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“…According to Asian [6], Japanese [39] and Brazilian [40] studies, the carriage rate in these populations was found to be lower than that reported for the Caucasian [35,41]. The lower carriage has also been reported in the Arab population where in Syrian Arabs, the rate was 12.5% and 8.6% in chronic periodontitis and controls [42].…”

Section: Discussionmentioning

confidence: 79%

“…However, this finding contrasts studies, which have shown a positive correlation of these alleles (-889, 2-2 and +4845, 2-2) with chronic periodontitis [18,33,34] in Caucasians or Arabs or Asians. The severity of chronic periodontitis and association with the tested genotypes (-889, +4845, -511 and +3954) also differed from other populations because amongst the Swahili participants, there was no correlation, whereas other studies report a positive relationship [18,35].…”

Section: Discussionmentioning

confidence: 81%

“…Although the frequency was low (16.3% in chronic periodontitis and 5.1% in controls), this allele was associated with chronic periodontitis. Other studies have reported frequencies for homozygous allele 1 at locus -889 as follows: D'Aiuto et al 2004 [36] (Caucasians) reported 39% in those with chronic periodontitis, Lopez et al 2005 [35] (Caucasians) reported 53.9% in chronic periodontitis and 64.35% in controls and Al-hebshi et al 2012 [37] (Yemenis) reported 20.3% in chronic periodontitis and 32.5% in controls. In all these studies, homozygous allele 1 of IL-1A-889 was not associated with chronic periodontitis.…”

Section: Discussionmentioning

confidence: 98%

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Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Wagaiyu¹,

Bulimo²,

Wanzala³

et al. 2014

IOSRJDMS

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 98%

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Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Wagaiyu¹,

Bulimo²,

Wanzala³

et al. 2014

IOSRJDMS

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“…The results showed that individuals carrying the positive genotype have significantly greater risk for developing periodontitis. 26 Most of these cross-sectional studies show a positive correlation between the genetic polymorphism and the periodontal state of the populations. The results should be interpreted with caution as the strength of the association is often weak, several confounding factors are not considered, the number of participants is often small, levels of disease are not well defined and differences in the effect of different polymorphisms can be expected although unknown up to now.…”

Section: Geneticsmentioning

confidence: 99%

An overview of the epidemiology of periodontal diseases in Latin America

Oppermann

2007

Braz. oral res.

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The aim of the present review was to identify the presence of periodontal diseases and the relative importance of known risk factors in Latin American countries. The retrieved data are sparse and inconsistent, lacking information for the majority of the countries. Gingivitis is ubiquitous in the region, affecting all ages independently of the socioeconomic background. The extension of bleeding may vary greatly, ranging from 40% to 70% of sites. The prevalence of aggressive periodontitis is higher in Latin America than in industrialized countries. Prevalence ranges from 0.3% to 4.5%, and the localized form is the less prevalent. The prevalence of chronic periodontitis is high, with a large variation (40-80%) probably due to differences in methodology and diagnostic criteria. Regional differences may be relevant. Known risk factors are present in the populations studied. Non-modifiable factors such as age, gender and genetics have been associated in Brazilian and Chilean populations. Tobacco smoking and diabetes are relevant risk factors. The importance of socioeconomic status, although present as a risk factor, has been largely underestimated. Oral hygiene is extremely deficient in the area although it is a cultural habit in most populations. It can be concluded that periodontal diseases are highly prevalent in Latin American populations. Its prevalence and extent are associated with known risk factors. Oral hygiene habits are deficient. Well designed epidemiological studies with external validity are needed. Descriptors: Epidemiology; Latin America; Gingivitis; Periodontitis; Risk factors.Resumo: O objetivo do presente estudo foi identificar a presença das doenças periodontais e a importância relativa de reconhecidos fatores de risco nos países da América Latina. Foram encontradas informações esparsas, sendo que os dados se mostraram inconsistentes. Para a maioria dos países não existem informações. Gengivite é um achado universal na região, afetando todas as idades, independentemente do nível socioeconômico. A extensão da presença de sangramento pode variar entre 40% e 70% dos sítios. A prevalência de periodontite agressiva é maior na América Latina do que nos países industrializados. A prevalência varia de 0,3% a 4,5%, sendo que a forma localizada é a menos prevalente. A prevalência de periodontite crônica é alta e pode variar muito (40% a 80%) provavelmente em decorrência de diferenças na metodologia e nos critérios diagnósticos. Diferenças regionais podem ser relevantes. Os fatores de risco reconhecidos estão presentes nas populações estudadas. Fatores próprios como idade, gênero e genética foram relacionados em estudos brasileiros e chilenos. Tabagismo e diabetes demonstraram-se importantes fatores de risco. A importância do nível socioeconômico, ainda que presente como um fator de risco, é muito pouco relevada. Higiene oral é extremamente deficiente na região, embora seja um hábito cultural presente na maioria das populações. Pode-se concluir que as doenças periodontais apresentam alta prevalênci...

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“…The first description of a genetic marker that identifies subjects who are more likely to have EARR was established by Al-Qawasmi et al (2003a), who identified an association between EARR during orthodontic treatment and the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) [interleukin-1β +3954 previously described as interleukin-1β +3953 (López et al, 2005) ] gene polymorphisms. IL-1 has been frequently associated with inflammatory events in connective and bone tissues (Alhashimi, 2001).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis

Wu¹,

Wang²,

Huang³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The purpose of this meta-analysis was to determine whether genetic variants of the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) gene polymorphisms were associated with orthodontic external apical root resorption (EARR). A meta-analysis was carried out using data entered into the PubMed and Embase electronic databases before October 5, 2012. A total of 7 studies were identified for meta-analysis. The strength of the relationship between IL-1β +3954 C>T polymorphism and the risk of EARR was assessed using odds ratio (OR). The studies provided overall OR estimates for EARR. Overall, the variant genotypes (CC and CT) of the IL-1β +3954 C>T polymorphism were unassociated with EARR risk compared with Similarly, no associations were found in the dominant and recessive models (dominant model, OR = 1.08, recessive model, OR = 1.85,. No publication bias was found, and no association was apparent between the IL-1β +3954 C>T polymorphism and risk of EARR in orthodontic treatment patients. Further multicenter and better-controlled studies are required to confirm these findings.

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Association of Interleukin‐1 Polymorphisms With Periodontal Disease

Abstract: Within the limits of this study, the results show that individuals carrying the positive genotype have significantly greater risk for developing periodontitis.

Cited by 81 publications

References 43 publications

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

An overview of the epidemiology of periodontal diseases in Latin America

Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis

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