Association of interleukin-1, interleukin-6, collagen type I alpha 1, and osteocalcin gene polymorphisms with early crestal bone loss around submerged dental implants: A nested case control study

Agrawal, Kaushal Kishor; Chand, Pooran; Singh, Saumyendra Vikram; Singh, Neetu; Gupta, Prashant; Garg, Ravindra Kumar; Chaurasia, Akhilanand; Anwar, Mohd; Kumar, Anil

doi:10.1016/j.prosdent.2021.05.023

Cited by 5 publications

(9 citation statements)

References 27 publications

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“…Similarly, Cosyn et al [16] presented the association between IL−1A (−889) polymorphism and the risk of implant failure. In contrast and unlike previous studies [28][29][30][31][32][33][34][35][36][37][38][39][40][41], we were unable to identify an association between this polymorphism and the risk of PID. However, our subgroup analysis showed that the association between IL−1A (−889) polymorphism and the risk of implant failure was statistically significant.…”

Section: Discussioncontrasting

confidence: 99%

“…IL−1B (−511) polymorphism is similar to IL−1B (+3954) polymorphism, which was found to have a strong role in chronic periodontitis and inflammation [46]. With regards to the association of IL−1B (−511) polymorphism with the risk of PID, one study [33] showed an elevated risk, while another study [41] reported a protective role of this polymorphism. In this view, the present meta-analysis was unable to confirm the association between IL−1B (−511) polymorphism and the risk of PID, and this zero association was already observed elsewhere .…”

Section: Discussionmentioning

confidence: 92%

“…Nine articles included Caucasians, three [29][30][31][32][33][34][35][36][37][38][39][40][41] Asians, and four [30][31][32][33][34][35][36][37] had participations with mixed ethnicity. Eight studies reported IL−1A (−889) polymorphism [16,[28][29][30][31]37,39,41], eight IL−1B (−511), three [28,30,39] IL−1B (+3953) polymorphism, seven IL−1B (+3954), two [30][31][32][33][34][35][36][37][38][39][40] IL−1RN (VNTR) polymorphism, three [28][29][30][31][32][33][34]…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Eight studies reported IL−1A (−889) polymorphism [16,[28][29][30][31]37,39,41], eight IL−1B (−511), three [28,30,39] IL−1B (+3953) polymorphism, seven IL−1B (+3954), two [30][31][32][33][34][35][36][37][38][39][40] IL−1RN (VNTR) polymorphism, three [28][29][30][31][32][33][34][35][36][37][38] composite genotype of IL−1A (−889) and IL−1B (+3953), and three [31][32][33][34][35][36] composite genotype of IL−1A (−889) and IL−1B (+3954) polymorphisms. Of the 16 articles, the outcomes were as follows: seven articles : implant failure; six articles [31][32][33][34][35][36][37][38][39]…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

et al. 2021

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Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between IL−1 polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between IL−1A (–889), IL−1B (−511), IL−1B (+3953), and IL−1RN (VNTR) polymorphisms and the risk of dental PIDs, but there was an increased risk of IL−1B (+3954) in the patients with PIDs. In addition, an association of the composite genotype of IL−1A (−889)/IL−1B (+3953) was observed with the risk of PIDs, but not for the composite genotype of IL−1A (−889)/IL−1B (+3954). The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. Conclusions: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of IL−1A (−889)/IL−1B (+3953) and IL−1B (+3954) were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of IL−1B (+3954) polymorphism were also associated with an elevated risk of PID.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 92%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

et al. 2021

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“…Thus, a successful early healing process is essential to optimise the outcomes of dental implant therapies. The early healing procedure of dental implant placement has been investigated histologically,3 clinically4 and under inflammatory conditions 5…”

Section: Introductionmentioning

confidence: 99%

Patient-reported outcome measures following surgeries in implant dentistry and associated factors: a cross-sectional study

Sun

et al. 2022

BMJ Open

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ObjectivesWe aimed to evaluate the patient-reported outcome measures (PROMs) of dental implant surgeries and analyse the associated indicators.DesignA cross-sectional study design was used.SettingDepartment of Oral Implantology, Hospital of Stomatology, Wuhan University (May 2020–April 2021).ParticipantsParticipants with missing teeth in need of implant-supported rehabilitation.InterventionsDental implant placement and/or bone augmentation procedures.Primary and secondary outcome measuresThe primary outcome was discomfort on postoperative day 1, measured using a numerical rating scale (NRS). Secondary outcomes included pain and anxiety during surgery; discomfort on postoperative days 3, 7 and 14; and post-surgical complications.ResultsA total of 366 participants were included, of which 288 (78.7%) and 328 (89.7%) reported no to mild pain and anxiety (NRS 0–3) during surgery, respectively. The proportion of patients reporting discomfort decreased from postoperative day 1 (57.7%) to day 3 (36.1%) and day 7 (17.5%). The most frequent postoperative adverse events were pain and swelling. Patient-related factors (age, sex, smoking, alcohol consumption, history of periodontitis, and pain and anxiety during surgery) and surgery-related factors (type and extent of surgical procedure) were analysed. The factors associated with the severity of discomfort after surgery included alcohol consumption, pain perception during surgery, bone augmentation procedures and age (p<0.05). Similarly, the factors associated with the duration of discomfort included alcohol consumption, pain perception during surgery and age (p<0.05).ConclusionsPROMs related to dental implant surgeries can be predicted using certain risk indicators. Alcohol consumption, pain during surgery and age were associated with discomfort following dental implant surgery.

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Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants

Agrawal,

Singh,

Chand

et al. 2024

Journal of Taibah University Medical Sciences

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Association of interleukin-1, interleukin-6, collagen type I alpha 1, and osteocalcin gene polymorphisms with early crestal bone loss around submerged dental implants: A nested case control study

Cited by 5 publications

References 27 publications

Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

Patient-reported outcome measures following surgeries in implant dentistry and associated factors: a cross-sectional study

Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants

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