Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

Mohammadi, Hady; Roochi, Mehrnoush Momeni; Sadeghi, Masoud; Garajei, Ata; Heidar, Hosein; Meybodi, Ali Aghaie; Dallband, Mohsen; Mostafavi, Sarton; Mostafavi, Melina; Salehi, Mohammad; Tadakamadla, Jyothi; Sadeghi-Bahmani, Dena; Brand, Serge

doi:10.3390/pathogens10121600

Cited by 7 publications

(5 citation statements)

References 50 publications

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“…In addition, the T allele and CT genotype of IL−1B +3954 polymorphism were also associated with an elevated risk of PID. In subgroup analysis no association was found between the polymorphisms evaluated and the risk of peri-implantitis [28]. However, the results of the study have to be interpreted with caution because the authors included in the same group of PID, patients with peri-implantitis, patients with marginal bone loss and patients with implant failure.…”

Section: Discussionmentioning

confidence: 92%

“…In a recent meta-analysis, which evaluated association between interleukin-1 polymorphisms and susceptibility to PID, the authors observed that there was no association between IL−1A −889, IL−1B −511 and IL−1RN (VNTR) polymorphisms and the risk of PID [28]. In contrast, an association was observed between the composite genotype of IL−1A −889 and IL−1B +3954 and PID.…”

Section: Discussionmentioning

confidence: 99%

“…Some of them do not refer to confounding variables such as periodontal condition, ethnicity and smoking habits. Furthermore, many studies, including published systematic reviews, assess the relationship of these polymorphisms with the peri-implant disease, pooling in the same group patients with bone loss, implant loss, and peri-implantitis [27][28][29]. However, peri-implant tissue health can exist around implants with variable levels of bone support [6].…”

Section: Introductionmentioning

confidence: 99%

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Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

et al. 2022

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Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis. Therefore, the current systematic review evaluates what is reported about the role of genetics, more specifically of single nucleotide polymorphisms (SNP) on IL-1 and variable number of tandem repeats (VNTR) on IL-1RN, in the development of peri-implantitis. This systematic review was carried out by screening PubMed, B-on, Cochrane and Scopus databases, for articles English, Spanish, and Portuguese, with no limit regarding the publication year. Eight articles were selected for systematic review and four for meta-analytic syntheses. Our results show that although there is a lack of consensus in the literature, there seems to be an association between IL-1A, IL-1B, and IL-1RN polymorphisms with peri-implantitis. The results of the meta-analysis showed that patients who have the polymorphic allele at position +3954 of the IL-1B gene have on average almost twice the risk of developing peri-implantitis (odds ratio = 1.986, 95% confidence interval).

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

et al. 2022

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“…In 2017, Thymi et al [29] designed a prospective cohort study to answer whether bruxism is a risk factor for peri-implantation complications. On the other hand, peri-implantitis is associated with elevated levels of IL-1β in GCF [30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Bruxism Influence on Volume and Interleukin-1β Concentration of Gingival Crevicular Fluid: A Preliminary Study

et al. 2022

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Bruxism is occlusal behaviour that often leads to stomatognathic system overload. Inflammatory markers in the periodontium are detectable in the gingival crevicular fluid (GCF). GCF production fluctuates due to various factors. Our study aimed to assess the effect of tooth clenching or grinding on GCF volume and proinflammatory IL-1β concentration in GCF. This pilot study was carried out on 20 participants aged 21 to 28 with good general health (per 10 people studied and control groups). GCF volume was measured with Periotron 8010 after absorbing for 30 s with PerioPaper strips. Twelve samples were collected from each patient—the buccal and lingual surfaces of teeth 16, 11, 24, 36, 31, and 44 were included. Laboratory examination of IL-1β concentration was performed. In patients with pathological tooth wear, a tendency to increase GCF secretion and IL-1β concentration in GCF was found. GCF volumes were higher in posterior teeth, while IL-1β levels were higher in anterior teeth. Crevices at the molars seem to have a potential predictive value in diagnosing periodontal microinflammation in patients with probable bruxism. Due to occlusal overload, these bruxists are more prone to microinflammatory processes in the periodontium. Further studies in a broader group are required to confirm this correlation.

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“…A current meta-analysis showed that IL-1B −3954 C > T polymorphism had a very strong relationship in the periodontitis risk with OR (95% CI), 0.66 (0.52–0.80) [ 10 ]. Quite interestingly, the framework genotype of IL-1A −889 /IL-1B +3953 and IL-1B +3954 were significantly associated with the risk of dental peri-implant disease [ 31 ]. For IL-1A −889 polymorphism, the T allele, compared to the C allele, generated a strong expression of IL-1α, quite similarly to the TT genotypes compared to the CC genotype [ 13 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population

Brodzikowska

Górski

Bogusławska-Kapała

2022

IJERPH

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Periodontitis is a chronic multifactorial inflammatory disease originating from microbial, environmental and genetic factors. The present study aimed to find an association of genetic polymorphisms at IL-1A−889 and IL-1B+3953 loci in Polish patients with stage III grade B periodontitis and periodontally healthy subjects. Fifty patients with stage III grade B periodontitis (tests) and thirty-five periodontally healthy controls were included in the study. To determine IL-1A and IL-1B gene polymorphisms, buccal swab-derived DNA obtained by means of the GenoType PST test was used. There were no statistically significant differences regarding the prevalence of IL-1A−889 or IL-1B+3953 alleles between groups. The frequencies of different IL-1A−889 genotypes did not differ significantly between groups. The IL-1B+3953 C/T genotype was significantly more predominant in periodontitis patients than in controls, whereas C/C genotype prevalence was significantly lower in the test group. Complex genotypes consisting of at least one IL-1A−889 and IL-1B+3953 T allele occurred significantly more frequently in subjects with periodontitis. Stage III grade B periodontitis may be associated with the IL-1B+3953 T allele and composite IL-1 polymorphism. Reduced susceptibility to periodontal disease was present in IL-1A−889 and IL-1B+3953 C/C homozygotic patients.

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Association between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

Cited by 7 publications

References 50 publications

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Bruxism Influence on Volume and Interleukin-1β Concentration of Gingival Crevicular Fluid: A Preliminary Study

Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population

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