Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population

Brodzikowska, Aniela; Górski, Bartłomiej; Bogusławska-Kapała, Agnieszka

doi:10.3390/ijerph192214687

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…Interestingly, there was no statistical difference in the expression of IL-1β among groups, which has been proved to be the key indicator of periodontitis. 20 – 22 High expression level of TNF-α in the group of 140 g was shown, while no significant difference existed among the groups in the results of IL-6 (Fig. S 3a–c ).…”

Section: Resultsmentioning

confidence: 89%

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

Zheng,

Lu,

Chen

et al. 2024

Int J Oral Sci

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The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and the criteria for evaluating optimal force have not been yet established. Here, by employing 3D finite element analysis methodology, we found that the apical distal region (A-D region) of mesial roots is particularly sensitive to orthodontic force in rats. Tartrate-resistant acidic phosphatase (TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams (g), leading to alveolar bone resorption and tooth movement. When the force reached 80 g, TRAP-positive osteoclasts started appearing on the root surface in the A-D region. Additionally, micro-computed tomography revealed a significant root resorption at 80 g. Notably, the A-D region was identified as a major contributor to whole root resorption. It was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement, inclination, and hyalinization. These findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat model. Collectively, our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’ orthodontic treatment.

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Section: Resultsmentioning

confidence: 89%

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

Zheng,

Lu,

Chen

et al. 2024

Int J Oral Sci

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“…The most periodontitis-related SNPs have been studied in the Toll-like receptor-2 (TLR-2) [16], TLR-4 [17], Fc-γ receptor (FCGR2A) [18], interleukin-1 (IL-1) [19][20][21], IL-4 [22], IL-6 [23][24][25], IL-10 [23,26], IL-18 [27,28], vitamin D receptor [11,29], tumor necrosis factor alpha (TNFA) [30][31][32], matrix metalloproteinase (MMP) [33,34], and cyclo-oxygenase-2 (COX-2) [35].…”

Section: Periodontitis-related Genetic Variation 21 Snps In Inflammat...mentioning

confidence: 99%

Epigenetics and Stem Cells Applications in Periodontal Therapy

Kafa

2024

Recent Advances and Future Perspectives in Periodontology [Working Title]

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While periodontitis is closely linked with pathogen outgrowth, many patients have the risk of recurrence after therapy. Variations of inflammatory genes are associated with an increased susceptibility of periodontitis. Epigenetics can regulate these gene expression. In this chapter, we will highlight on the potential role of epigenetic changes in different facets, more particularly in genes involved in inflammation. Epigenetics act through remodeling of chromatin and can selectively activate or inactivate genes, determining their expression. Epigenetics could play an essential role in understanding the mechanism of gene-environment interactions, and the factors which stimulate periodontitis and reduce its response to therapy are now the subject of many studies. Also, mesenchymal stem cells (MSCs) are a promising source to regenerate periodontal tissues. They could be a good alternative to the adopted therapies, ignoring the artificial biomaterial limitations. They could be considered as a natural process for periodontium regeneration and has an immunomodulatory role to resolute the infection. For this reason, it is necessary to investigate and evaluate MSCs applicability in humans, and their clinical approach involved in regeneration of periodontal tissues.

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“…Among them, interleukin (IL-6) is a potent pro-inflammatory cytokine closely related to periodontal destruction. It is produced in the body after exposure to immunological and psychological influences and plays a vital role in neuroendocrine and psychophysiological responses to stress [19,20].…”

Section: Fig 2 the Way Psychoemotional Stress Affects Periodontal Tis...mentioning

confidence: 99%

Pathophysiology Mechanisms of the Stress Impact on Periodontal Tissues

Денефіль,

Чорній,

Бойцанюк

et al. 2023

Перспективи та інновації науки

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Stresses of wartime: chronic long-term and acute short-term stress episodes that periodically increase it, can be physiological and neuropsychological (psycho-emotional). Constant fatigue, anxiety and long-term stress exhaust the body, harm the physical condition, can become a trigger for depression, the development of post-traumatic stress disorder, and this, in turn, can cause the development of pathological conditions of organs and systems, in particular periodontal tissues.Purpose of the article is to review available in free access scientific papers on the problem of pathophysiological mechanisms of the influence of stress on periodontal tissues, emphasizing the emerging role of neuroendocrine and neuroimmune mediators in the pathophysiology of inflammatory diseases.Materials and methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «adrenal glands», «cortisol», «endocrine system», «periodontal disease», «stress» were used in various combinations. The search considered works published from 2010 until November 2023 by using the abovementioned key words as we want to include only up to date information. In total there were found 202 scientific papers corresponding to above mentioned key words. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones.Results. A comprehensive study of the available information related to relationship between psychological disturbances and periodontal disease was carried out. Stress triggers emotional and physiological responses and serves as a significant modifiable risk factor for both mental and physical health conditions. Wars have profound social, economic, and psychological consequences for affected individuals and communities. The initiation and progression of periodontitis are related to multiple aetiologic and risk factors, the most important of which are the local microbiota and host immune response. It is established that stress reduces the flow of salivary secretions which in turn can enhance dental plaque formation. The

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Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population

Cited by 8 publications

References 45 publications

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

Epigenetics and Stem Cells Applications in Periodontal Therapy

Pathophysiology Mechanisms of the Stress Impact on Periodontal Tissues

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