Association of Insulin Resistance with Alanine Aminotransferase Activity in Patients with Nonalcoholic Fatty Liver Disease

Wu, Wai-Wah; Hsu, Ching–Sheng; Wang, Pin‐Chao; Lin, Hans Hsienhong; Kao, Jia‐Horng

doi:10.1016/s1016-3190(08)60050-6

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Some previous studies have suggested that elevated ALT levels and fatty livers were independently associated with increased risk of metabolic syndromes [29,30] . On the other hand, consistent to our results, a community-based study in Taiwan, a country with a relatively low prevalence of diabetes mellitus [31] showed no increased prevalence of metabolic syndrome for NAFLD patients with elevated ALT levels. Putting together, we suggest that serum ALT level seems not be a good independent predictor of metabolic syndrome in NAFLD patients.…”

Section: Discussionsupporting

confidence: 91%

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Ghamar-Chehreh

Amini

Khedmat

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionsupporting

confidence: 91%

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Ghamar-Chehreh

Amini

Khedmat

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…This suggests that hepatic steatosis could damage hepatocytes through the “second hit” as opposed in the pathogenesis of NAFLD [43]. Our earlier study indicated that NAFLD patients with ALT elevation had an increased risk of carotid atherosclerosis compared to those with normal ALT levels, suggesting that serum ALT levels could serve as a clinical marker that is predictive of CVD risk [44]. Taking these data together, our findings strengthen the association between fatty liver, elevated ALT levels and CVD risk.…”

Section: Discussionsupporting

confidence: 79%

Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk

Tseng

Hsieh

Hsu

et al. 2012

The Kaohsiung J of Med Scie

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Non-alcoholic fatty liver disease is associated with an increased risk of metabolic and cardiovascular diseases. Whether the severity of fatty liver on ultrasound correlates with metabolic or cardiovascular risk remains unclear. A total of 1000 people receiving health examinations were enrolled, and 126 were excluded due to the presence of HBsAg, anti-HCV, known hepatic disorders or alcohol use (>140 g/wk). Significant fatty liver consisted of moderate and severe fatty liver on ultrasound. The definition of central obesity was modified to a waist circumference of >90 cm in men and >80 cm in women. Framingham risk score was used to estimate the risk of cardiovascular disease. A total of 874 subjects (485 women and 388 men with a mean age of 52.07 ± 11.68 years) were included in the final analysis. By using logistic regression analyses stratified by gender, the odds ratio for the prevalence of diabetes mellitus, metabolic syndrome and risk of cardiovascular disease increased with increasing fatty liver status in both genders (p ≤ 0.001). The difference was not only present between individuals with fatty liver vs. non-fatty liver but also between the mild fatty liver and significant fatty liver groups (p < 0.05). In conclusion, the severity of fatty liver on ultrasound could be useful for the risk stratification of metabolic syndrome, diabetes mellitus and cardiovascular disease in clinical practice.

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“…Kittichai et al had life style change intervention and they didn't have decrease in insulin level and HOMA but Nobili et al and Wang et al (14) had decrease of insulin and HOMA with change in life style and diet. This is in disagreement with our study.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies also have reported a significant inverse relationship between the level of cardio respiratory fitness and hepatic fat contents (4,14). Nikroo et al showed that addition of lowcalorie diet to aerobic exercise was more effective in the improvement of quality of life and that decrease of grading of ultrasonography features in patients with NASH (15).…”

Section: Introductionmentioning

confidence: 99%

“…Nikroo et al showed that addition of lowcalorie diet to aerobic exercise was more effective in the improvement of quality of life and that decrease of grading of ultrasonography features in patients with NASH (15). It was found that inverse association between fitness categories and the prevalence of NAFLD is independent upon body mass index (BMI), visceral fat content and waist circumference (WC) (14). A significant relationship was seen between the severity of histological injuries and decreased peak oxygen consumption (VO 2 peak) in overweight and obese patients with NAFLD (16).…”

Section: Introductionmentioning

confidence: 99%

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How Does Addition of Regular Aerobic Exercises, Influence the Efficacy of Calorie-Restricted Diet in Patients with Non-Alcoholic Steatohepatatis (NASH)?

et al. 2017

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Background: Nonalcoholic fatty liver (NAFLD) is a worldwide, leading cause of chronic liver disease, not yet approved medical treatment standards. The aim is to assess the effects of aerobic exercise sand calorie-restricted (CR) diet on many clinical and laboratory findings in patients with Nonalcoholic Steatohepatatis (NASH). Methods: In Randomized controlled trial study, in Mashhad, between February 2010 -August 2011, Twenty-five patients with NASH, in ranging ages of 18 -55, were randomly selected to be divided in to two groups, who received CR-diet and aerobic exercise (n = 12) and CR-diet alone (n = 13). We measured Anthropometric indices, cardio-respiratory fitness, and biochemical profiles in three steps, in baseline, and after 8 -12 weeks of intervention. We measured hepatic steatosis and patient's quality of life by ultra-sonography and short form (questionnaire) 36 in three steps. Data was then analyzed by paired and independent samples T Test. Results: We observed a significant improvement in BP, FBS, TG, HOMA-IR, ultra-sonography grading of steatosis and quality of life, only in patients who received aerobic exercises. (P value 0.021, 0.005, 0.006, 0.042, 0.010 and 0.012). Waist circumference, waist-toheight ratio, serum ALT and peak oxygen consumption improved in both groups; however, improvement was significantly, higher in patients who received aerobic exercises (P value 0.027, 0.011, 0.020 and 0.020). Body weight, BMI, body fat percentage and AST improved in both groups but they were not significantly different. No significant changes noted in total cholesterol, LDL and HDL in groups. Conclusions: Add of aerobic exercises to CR diets can, not only enhance the therapeutic effects of calorie-restricted diet, but also bring more benefits in patients with NASH.

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Association of Insulin Resistance with Alanine Aminotransferase Activity in Patients with Nonalcoholic Fatty Liver Disease

Cited by 4 publications

References 28 publications

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk

How Does Addition of Regular Aerobic Exercises, Influence the Efficacy of Calorie-Restricted Diet in Patients with Non-Alcoholic Steatohepatatis (NASH)?

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