Association of Insulin-Related Serum Factors with Colorectal Polyp Number and Type in Adult Males

Comstock, Sarah S.; Xu, Diana; Hortos, Kari; Kovan, Bruce; McCaskey, Sarah; Pathak, Dorothy R.; Fenton, Jenifer I.

doi:10.1158/1055-9965.epi-14-0249-t

Cited by 18 publications

(14 citation statements)

References 47 publications

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“…Our study identified associations of IFN-α2, IL-10, MCP-3, MDC, IL-7 and IL-8 with colorectal polyps. Additionally, TNF-α, IP-10 and VEGF have been previously reported to be associated with colorectal polyps in this population (Comstock et al, 2014a; Comstock et al, 2014c). Therefore, data from the current study population supports that of other studies analyzing serum cytokines in cases of colorectal neoplasia.…”

Section: Discussionmentioning

confidence: 69%

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Association of serum cytokines with colorectal polyp number and type in adult males

Comstock

Hortos

et al. 2016

European Journal of Cancer Prevention

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Chronic inflammation contributes to colorectal carcinogenesis. To determine if serum cytokines are associated with colon polyps, 126 asymptomatic men (48–65yr) were recruited at colonoscopy. Serum cytokine concentrations were measured. Odds ratios were determined using polytomous logistic regression for polyp number and type. Males with serum monocyte chemotactic protein-3 (MCP-3) or soluble interleukin-4 receptor (sIL-4R) concentrations in the highest tertile were 0.2 times less likely to have ≥3 polyps relative to no polyps. For each increase in serum MCP-3 or sIL-4R tertile a man was about 0.4 times less likely to have ≥3 polyps than no polyps. Males with serum concentrations of interferon-α2 (IFN-α2) or interleukin (IL)-7 in the highest tertile were 3 times more likely to have an adenoma relative to no polyps. Those with serum IL-8 concentrations in the highest tertile were 4 times more likely to have an adenoma relative to no polyps. For each increase in serum IFN-α2, IL-7 or IL-8 tertile an individual was 1.8 times more likely to have an adenoma than no polyp. Serum concentrations of MCP-3, sIL-4R, IFN-α2, IL-7 and IL-8 may indicate which men are more likely to have colorectal polyps.

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Section: Discussionmentioning

confidence: 69%

“…Some details about this study population have recently been published (Comstock et al, 2014a; Comstock et al, 2014b; Comstock et al, 2014c). Briefly ( Table 1 ), 57 (45%) of the 126 participants had at least one polyp.…”

Section: Resultsmentioning

confidence: 99%

Association of serum cytokines with colorectal polyp number and type in adult males

Comstock

Hortos

et al. 2016

European Journal of Cancer Prevention

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“…Smoking status was assessed as “ever smoked” or “never smoked”. Each individual received a full colonoscopy as previously described (14). Serum and plasma fractions were separated from blood and stored at −80° C.…”

Section: Methodsmentioning

confidence: 99%

Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas

Pickens

Lane-Elliot

Comstock

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Altered lipid metabolism and plasma fatty acid (FA) levels are associated with colorectal cancer (CRC). Obesity and elevated waist circumference (WC) increase the likelihood of developing precancerous colon adenomas. Methods Venous blood was collected from 126 males, ages 48 to 65 years, who received routine colonoscopies. Plasma phospholipid (PPL) FAs were isolated, derivatized, and then analyzed using gas chromatography. Odds ratios (ORs) and 95% confidence intervals were determined using polytomous logistic regression after adjusting for confounding factors (i.e. age, smoking, WC, and BMI). Results PPL palmitic acid (PA) was inversely correlated with the presence of colon adenomas (p = 0.01). For each unit increase in palmitoleic acid (OR: 3.75, p = 0.04) or elaidic acid (OR: 2.92, p = 0.04) an individual was more likely to have adenomas relative to no colon polyps. Higher enzyme activity estimates (EAEs) of stearoyl-CoA desaturase-1 (SCD-1, p = 0.02) and elongation of very long chain-6 (Elovl-6, p = 0.03) were associated with an individual being approximately 1.5 times more likely to have an adenoma compared to no polyps. Conclusions PPL FAs and EAEs, which have previously been associated with CRC, are significantly different in those with adenomas when compared to those without polyps. PPL PA, elaidic acid, and SCD-1 and Elovl-6 EAEs are associated with adenomas independent of BMI and WC. Impact PPL PA, elaidic acid, and SCD-1 and Elovl-6 EAEs are associated with adenomas even after adjusting for obesity-related risk factors and may function as novel biomarkers of early CRC risk.

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“…In our study, an increased risk associated with baldness was virtually confined to adenomas of small size, tubular histology, and/or 1–2 adenomas. Interestingly, in a recent study that examined insulin-related serum markers in relation to types of CRA in Caucasian males, circulating C-peptide, a marker of insulin secretion, was strongly associated with tubular adenomas (OR comparing extreme tertiles, 3.8; 95% CI, 1.3–11.2) ( Comstock et al , 2014 ). Thus, the insulin pathway may be particularly relevant to linking baldness to tubular adenomas and, indeed in our study, a positive association was suggested for large or multiple adenomas if they are of tubular histology.…”

Section: Discussionmentioning

confidence: 99%

Male pattern baldness and risk of colorectal neoplasia

et al. 2016

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Background:Male pattern baldness is positively associated with androgens as well as insulin-like growth factor 1 (IGF-1) and insulin, all of which are implicated in pathogenesis of colorectal neoplasia.Methods:From 1992 through 2010, we prospectively followed participants in the Health Professionals Follow-Up Study. Hair pattern at age 45 years was assessed at baseline with five image categories (no baldness, frontal-only baldness, frontal-plus-mild-vertex baldness, frontal-plus-moderate-vertex baldness, and frontal-plus-severe-vertex baldness). Cancer analysis included 32 782 men and used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted to men who underwent at least one endoscopy over the study period, adenoma analysis included 29 770 men and used logistic regressions for clustered data to estimate odds ratios (ORs) and 95% CIs.Results:Over the mean follow-up of 15.6 years, 710 cases of colorectal cancer (478 for colon, 152 for rectum, and 80 unknown site) developed. Significantly increased risks associated with frontal-only baldness and frontal-plus-mild-vertex baldness relative to no baldness were observed for colon cancer with respective HR being 1.29 (95% CI, 1.03–1.62) and 1.31 (95% CI, 1.01–1.70). Over the 19-year study period, 3526 cases of colorectal adenoma were detected. Evidence for an increased risk of colorectal adenoma relative to no baldness was significant with frontal-only baldness (OR, 1.16; 95% CI, 1.06–1.26) and borderline insignificant with frontal-plus-severe-vertex baldness (OR, 1.14; 95% CI, 0.98–1.33).Conclusions:Subtypes of male pattern baldness at age 45 years were positively associated with colorectal neoplasia. Future studies are warranted to confirm our results and to determine the predictive value of male pattern baldness to identify those at high risk for colorectal neoplasia.

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Association of Insulin-Related Serum Factors with Colorectal Polyp Number and Type in Adult Males

Cited by 18 publications

References 47 publications

Association of serum cytokines with colorectal polyp number and type in adult males

Association of serum cytokines with colorectal polyp number and type in adult males

Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas

Male pattern baldness and risk of colorectal neoplasia

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