Association of serum cytokines with colorectal polyp number and type in adult males

Comstock, Sarah S.; Xu, Diana; Hortos, Kari; Kovan, Bruce; McCaskey, Sarah; Pathak, Dorothy R.; Fenton, Jenifer I.

doi:10.1097/cej.0000000000000160

Cited by 10 publications

(6 citation statements)

References 56 publications

(63 reference statements)

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“…Contrary to data presented by Henry et al [ 27 ] but corroborating findings of Comstock et al [ 28 ], we have observed that circulating IL-7 was elevated in patients with adenomas, as compared to controls. Similar increase in several other cytokines was reported elsewhere [ 28 – 31 ]. To resolve discrepancy between the reports, we investigated IL-7 in the context of adenomas, their number, size, and growth pattern.…”

Section: Discussionsupporting

confidence: 88%

Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon

Krzystek−Korpacka

Zawadzki²,

Neubauer

et al. 2016

Cancer Immunol Immunother

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Interleukin (IL)-7 is a cytokine essential for protective immunity, and it is considered as a promising agent for cancer immunotherapy. Recent studies, however, appear to associate IL-7 with aggressiveness of solid tumors. The IL-7 has been less studied in colorectal cancer (CRC) and conditions associated with increased risk of CRC development. To explore IL-7 status in bowel diseases, it was measured immunofluorometrically in 431 individuals (110 with CRC) by using Luminex platform. A level of IL-7 in CRC patients was significantly higher than in controls, did not differ from those with adenomas, but was lower than in both active and inactive inflammatory bowel disease (IBD) cases. In CRC, IL-7 was higher in patients with lymph node and distant metastases and with tumors located in right colon. In adenomas, IL-7 elevation was associated exclusively with villous growth pattern, while in IBD, circulating IL-7 reflected clinical activity of Crohn’s disease and ulcerative colitis. Systemic TNFα, IL-10, and PDGF-BB were independent predictors of circulating IL-7. In summary, our study is the first to demonstrate IL-7 elevation in CRC in association with metastatic disease and tumor location. Both associations should be considered when designing IL-7-based immunotherapies for CRC. Further studies on IL-7 functionality in CRC are necessary.

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Section: Discussionsupporting

confidence: 88%

Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon

Krzystek−Korpacka

Zawadzki²,

Neubauer

et al. 2016

Cancer Immunol Immunother

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show abstract

“…Similarly, no significant associations were found for C-peptide, GM-CSF, interferon-α (IFN-α), IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-17A, MIP-1β, and vascular endothelial growth factor and adenoma [137][138][139]. Although associations were reported for IFN-α2, IL-7, IL-8, MCP-3, and SIL-4R in cross-sectional analyses [137,140] they have not been prospectively confirmed.…”

Section: Circulating Inflammation Markersmentioning

confidence: 99%

Colorectal Adenomas—Genetics and Searching for New Molecular Screening Biomarkers

Siskova

Červená

Král

et al. 2020

IJMS

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Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. CRC outcome is closely related to the respective stage of CRC and is more favorable at less advanced stages. Detection of early colorectal adenomas is the key to survival. In spite of implemented screening programs showing efficiency in the detection of early precancerous lesions and CRC in asymptomatic patients, a significant number of patients are still diagnosed in advanced stages. Research on CRC accomplished during the last decade has improved our understanding of the etiology and development of colorectal adenomas and revealed weaknesses in the general approach to their detection and elimination. Recent studies seek to find a reliable non-invasive biomarker detectable even in the blood. New candidate biomarkers could be selected on the basis of so-called liquid biopsy, such as long non-coding RNA, microRNA, circulating cell-free DNA, circulating tumor cells, and inflammatory factors released from the adenoma into circulation. In this work, we focused on both genetic and epigenetic changes associated with the development of colorectal adenomas into colorectal carcinoma and we also discuss new possible biomarkers that are detectable even in adenomas prior to cancer development.

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“…Liu [7] reported that constipation can signi cantly increase the incidence of colorectal polyps, but did not signi cantly increase the incidence of colorectal cancer even it is a risk factors for colorectal cancer. Comstock and colleagues [8] reported in ammatory cytokines level in patients with colorectal polyp was higher than that in patients without colorectal polyp. Their nding suggested colorectal polyp are associated with chronic intestinal in ammation.…”

Section: Correlation Between Colorectal Polyp and Sibomentioning

confidence: 94%

The value of hydrogen and methane breath test in predicting colorectal polyps

Zhang

Liu

Xie

et al. 2020

Preprint

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BackgroundTo investigate the value of hydrogen and methane breath test in predicting colorectal polyps. Methods382 patients were enrolled in this study. They were divided into colorectal polyps group and Non polyps group as control. Hydrogen and methane breath test was used in both groups for small intestinal bacteria overgrowth (SIBO) diagnosis. All patients were examined by colonoscopy to investigate colorectal polyps. Diamine oxidase, D-lactate and Lipopolysaccharides (LPS) were measured in all patients to evaluate the intestinal barrier function.Results 1) The age of colorectal polys group is significantly higher than control group (P=0.000); the prevalence of colorectal polyps increases with age. 2) The prevalence of colorectal polys in male is significantly higher than female (P=0.004); 3) Lactuloses breath test (LBT) was used for small intestinal bacteria overgrowth (SIBO) diagnoses. Prevalence of hydrogen dominate SIBO and methane dominate SIBO in colorectal polys group were significantly higher than control group (P = 0.000, 0.013);4) The prevalence of constipation was higher in colorectal polys group than control group (P=0.023);5) The peoples who had high hydrogen production peoples showed less intestinal barrier function damage and lower LPS level than peoples who had low hydrogen production (P=0.029, 0.049);6) The sensitivity and specificity of SIBO is 75.5% and 51.0% respectively in SIBO diagnosis.ConclusionThe occurrence of colorectal polyp increase with age, the year 46 is a cut off age for peoples need colonoscopy examination. Male has a higher prevalence than female. Intestinal hydrogen may play a role in prevent intestinal mucosa damage via its antioxidant function. SIBO shows a positive relationship with colorectal polyp. Hydrogen and methane breath test is a useful mass prescreening method for colorectal polyp risk.

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Association of serum cytokines with colorectal polyp number and type in adult males

Cited by 10 publications

References 56 publications

Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon

Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon

Colorectal Adenomas—Genetics and Searching for New Molecular Screening Biomarkers

The value of hydrogen and methane breath test in predicting colorectal polyps

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